Q16548 | B2LA1_HUMAN | Bcl-2-related protein A1 (BCL2A1)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00452 | Bcl-2 - Apoptosis regulator proteins, Bcl-2 family | 37~140 |
3D structures mapped by conservation among orthologs
[ Domain: "Bcl-2 inhibitors of programmed cell death" // Bcl-2 ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL5283854 |  |
IC50 | = | 264.0 | nM | 377.85 | Cc1cs/c(=N\c2ccccc2)n1/N=C/c1ccc(O)c(O)c1O.Cl | Homo sapiens | CHEMBL5241830 | single protein format |
| CHEMBL5282175 |  |
IC50 | = | 365.0 | nM | 448.34 | Br.Oc1ccc(/C=N/n2c(C3CC3)cs/c2=N\c2ccccc2)c(O)c1O | Homo sapiens | CHEMBL5241830 | single protein format |
| CHEMBL1269202 |  |
IC50 | = | 400.0 | nM | 319.58 | CN(C)C1=C(Cl)C(=O)N(c2ccc(Cl)c(Cl)c2)C1=O | Homo sapiens | CHEMBL1273077 | single protein format |
| CHEMBL1272154 |  |
IC50 | = | 400.0 | nM | 448.73 | O=C1C(Cl)=C(N2CCN(CCOCCO)CC2)C(=O)N1c1ccc(Cl)c(Cl)c1 | Homo sapiens | CHEMBL1273077 | single protein format |
| CHEMBL1271993 |  |
IC50 | = | 450.0 | nM | 361.61 | O=C1C(Cl)=C(N2CCOCC2)C(=O)N1c1ccc(Cl)c(Cl)c1 | Homo sapiens | CHEMBL1273077 | single protein format |
| CHEMBL1271764 |  |
IC50 | = | 600.0 | nM | 374.65 | CN1CCN(C2=C(Cl)C(=O)N(c3ccc(Cl)c(Cl)c3)C2=O)CC1 | Homo sapiens | CHEMBL1273076 | single protein format |
| CHEMBL1272100 |  |
IC50 | = | 620.0 | nM | 404.68 | O=C1C(Cl)=C(N2CCN(CCO)CC2)C(=O)N1c1ccc(Cl)c(Cl)c1 | Homo sapiens | CHEMBL1273077 | single protein format |
| CHEMBL1269107 |  |
IC50 | = | 650.0 | nM | 586.6 | CC1=C(C2=C(C)C(=O)c3c(cc(O)c(O)c3Cc3ccccc3)C2=O)C(=O)c2cc(O)c(O)c(Cc3ccccc3)c2C1=O | Homo sapiens | CHEMBL1273518 | single protein format |
| CHEMBL1271495 |  |
IC50 | = | 690.0 | nM | 476.79 | O=C1C(Cl)=C(N2CCN(C/C=C/c3ccccc3)CC2)C(=O)N1c1ccc(Cl)c(Cl)c1 | Homo sapiens | CHEMBL1273077 | single protein format |
| CHEMBL1272047 |  |
IC50 | = | 800.0 | nM | 374.66 | C[C@@H]1CN(C2=C(Cl)C(=O)N(c3ccc(Cl)c(Cl)c3)C2=O)CCN1 | Homo sapiens | CHEMBL1273077 | single protein format |
| CHEMBL5283368 |  |
IC50 | = | 800.0 | nM | 427.55 | COc1ccc(C(c2c(-c3ccccc3)n(O)c3ccccc23)N2CCN(C)CC2)cc1 | Homo sapiens | CHEMBL5337579 | single protein format |
| CHEMBL1271825 |  |
IC50 | = | 1000.0 | nM | 340.21 | CN1CCN(C2=C(Cl)C(=O)N(c3ccccc3Cl)C2=O)CC1 | Homo sapiens | CHEMBL1273077 | single protein format |
| CHEMBL1271994 |  |
IC50 | = | 1000.0 | nM | 388.68 | CCN1CCN(C2=C(Cl)C(=O)N(c3ccc(Cl)c(Cl)c3)C2=O)CC1 | Homo sapiens | CHEMBL1273077 | single protein format |
| CHEMBL4522193 |  |
Ki | = | 84.0 | nM | 553.75 | CC(C)(C)c1ccc(N2CCN(S(=O)(=O)Nc3ccc(SCCc4ccccc4)cc3C(=O)O)CC2)cc1 | Homo sapiens | CHEMBL4344314 | assay format |
| CHEMBL4533559 |  |
Ki | = | 100.0 | nM | 583.78 | COc1cccc(CCSc2ccc(NS(=O)(=O)N3CCN(c4ccc(C(C)(C)C)cc4)CC3)c(C(=O)O)c2)c1 | Homo sapiens | CHEMBL4344314 | assay format |
| CHEMBL4576854 |  |
Ki | = | 100.0 | nM | 567.78 | CC(C)(C)c1ccc(CN2CCN(S(=O)(=O)Nc3ccc(SCCc4ccccc4)cc3C(=O)O)CC2)cc1 | Homo sapiens | CHEMBL4344314 | assay format |
| CHEMBL4558313 |  |
Ki | = | 150.0 | nM | 489.62 | O=C(O)c1cc(SCCc2ccccc2)ccc1NS(=O)(=O)c1ccc(-c2ccccc2)cc1 | Homo sapiens | CHEMBL4344314 | assay format |
| CHEMBL4462138 |  |
Ki | = | 170.0 | nM | 495.67 | O=C(O)c1cc(SCCc2ccccc2)ccc1NS(=O)(=O)c1ccc(C2CCCCC2)cc1 | Homo sapiens | CHEMBL4344314 | assay format |
| CHEMBL4454113 |  |
Ki | = | 250.0 | nM | 569.75 | CC(C)(C)c1ccc(N2CCN(S(=O)(=O)Nc3ccc(SCCc4cccc(O)c4)cc3C(=O)O)CC2)cc1 | Homo sapiens | CHEMBL4344314 | assay format |
| CHEMBL4463305 |  |
Ki | = | 280.0 | nM | 490.61 | O=C(O)c1cc(SCCc2ccccc2)ccc1NS(=O)(=O)c1ccc(-c2ccccc2)nc1 | Homo sapiens | CHEMBL4344314 | assay format |