Q16513 | PKN2_HUMAN | Serine/threonine-protein kinase N2 (PKN2)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00069 | Pkinase - Protein kinase domain | 662~916 | |
| PF00433 | Pkinase_C - Protein kinase C terminal domain | 937~979 | |
| PF02185 | HR1 - Hr1 repeat | 51~110 | |
| PF02185 | HR1 - Hr1 repeat | 137~200 | |
| PF02185 | HR1 - Hr1 repeat | 218~281 |
3D structures mapped by conservation among orthologs
[ Domain: "Protein kinase" // Pkinase_Tyr ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL388978 |  |
IC50 | = | 2.2 | nM | 466.54 | CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 | Homo sapiens | CHEMBL3820669 | single protein format |
| CHEMBL1214929 |  |
IC50 | = | 7.0 | nM | 265.32 | NCCNc1nc(-c2ccncc2)cc2cnccc12 | Homo sapiens | CHEMBL3387551 | single protein format |
| CHEMBL1082821 |  |
IC50 | = | 14.0 | nM | 402.28 | O=C(Nc1cc2cc[nH]c(=O)c2cc1Cl)[C@@H]1CNC[C@H]1c1ccc(Cl)cc1 | Homo sapiens | CHEMBL1120085 | single protein format |
| CHEMBL5182936 |  |
IC50 | = | 15.0 | nM | 255.32 | CCCn1c(-c2ccncc2)cc2c1CCNC2=O | Homo sapiens | CHEMBL5134826 | single protein format |
| CHEMBL225519 |  |
IC50 | = | 16.0 | nM | 213.24 | O=C1NCCc2[nH]c(-c3ccncc3)cc21 | Homo sapiens | CHEMBL5134826 | single protein format |
| CHEMBL250870 |  |
IC50 | = | 16.0 | nM | 241.29 | CCn1c(-c2ccncc2)cc2c1CCNC2=O | Homo sapiens | CHEMBL5134826 | single protein format |
| CHEMBL2147538 |  |
IC50 | = | 17.0 | nM | 293.37 | CC(C)(N)CNc1nc(-c2ccncc2)cc2cnccc12 | Homo sapiens | CHEMBL3387551 | single protein format |
| CHEMBL250871 |  |
IC50 | = | 30.0 | nM | 257.29 | O=C1NCCc2c1cc(-c1ccncc1)n2CCO | Homo sapiens | CHEMBL5134826 | single protein format |
| CHEMBL5175087 |  |
IC50 | = | 50.0 | nM | 289.34 | O=C1NC(c2ccccc2)Cc2[nH]c(-c3ccncc3)cc21 | Homo sapiens | CHEMBL5134826 | single protein format |
| CHEMBL3338837 |  |
IC50 | = | 58.0 | nM | 294.36 | CC(C)(N)CNc1nc(-c2ccncc2)nc2cnccc12 | Homo sapiens | CHEMBL3387551 | single protein format |
| CHEMBL5202568 |  |
IC50 | = | 60.0 | nM | 212.25 | O=C1CCCc2[nH]c(-c3ccncc3)cc21 | Homo sapiens | CHEMBL5134826 | single protein format |
| CHEMBL1990482 |  |
IC50 | = | 64.0 | nM | 238.25 | NC(=O)c1cccc2[nH]c(-c3ccncc3)nc12 | Homo sapiens | CHEMBL4628248 | single protein format |
| CHEMBL1605605 |  |
IC50 | = | 70.0 | nM | 320.26 | C[C@@H](N)[C@H]1CC[C@H](C(=O)Nc2ccncc2)CC1.Cl.Cl | Homo sapiens | CHEMBL1117933 | single protein format |
| CHEMBL1084892 |  |
IC50 | = | 110.0 | nM | 341.8 | CNC(C(=O)Nc1cc2cc[nH]c(=O)c2cc1Cl)c1ccccc1 | Homo sapiens | CHEMBL1117933 | single protein format |
| CHEMBL5205578 |  |
IC50 | = | 140.0 | nM | 392.89 | COC(=O)Nc1cc(-c2ccc(OC[C@@](C)(N)CC(C)C)c(Cl)n2)ccn1 | Homo sapiens | CHEMBL5161252 | single protein format |
| CHEMBL5187643 |  |
IC50 | = | 140.0 | nM | 255.32 | CC(C)n1c(-c2ccncc2)cc2c1CCNC2=O | Homo sapiens | CHEMBL5134826 | single protein format |
| CHEMBL4647033 |  |
IC50 | = | 170.0 | nM | 317.15 | NC(=O)c1cc(Br)cc2[nH]c(-c3ccncc3)nc12 | Homo sapiens | CHEMBL4628248 | single protein format |
| CHEMBL252724 |  |
IC50 | = | 260.0 | nM | 227.27 | Cn1c(-c2ccncc2)cc2c1CCNC2=O | Homo sapiens | CHEMBL5134826 | single protein format |
| CHEMBL1945559 |  |
IC50 | = | 300.0 | nM | 363.25 | Cn1c2c(c3ccc(Cl)c(Cl)c31)C(C#N)C1(CCNCC1)NC2=O | Homo sapiens | CHEMBL1947862 | single protein format |
| CHEMBL5182853 |  |
IC50 | = | 350.0 | nM | 255.32 | CCn1c(-c2ccncc2)cc2c1CCN(C)C2=O | Homo sapiens | CHEMBL5134826 | single protein format |