Q16512 | PKN1_HUMAN | Serine/threonine-protein kinase N1 (PKN1)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00069 | Pkinase - Protein kinase domain | 617~874 | |
| PF00433 | Pkinase_C - Protein kinase C terminal domain | 895~937 | |
| PF02185 | HR1 - Hr1 repeat | 39~98 | |
| PF02185 | HR1 - Hr1 repeat | 128~193 | |
| PF02185 | HR1 - Hr1 repeat | 214~275 |
3D structures mapped by conservation among orthologs
[ Domain: "HR1 repeat" // HR1 ]
[ Domain: "Protein kinase" // Pkinase_Tyr ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL388978 |  |
IC50 | = | 1.0 | nM | 466.54 | CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 | Homo sapiens | CHEMBL3108317 | single protein format |
| CHEMBL3218297 |  |
IC50 | < | 1.0 | nM | 422.49 | CS(=O)(=O)O.O=C(NCc1cccc(O)c1)Nc1nc(-c2ccncc2)cs1 | Homo sapiens | CHEMBL3224501 | single protein format |
| CHEMBL1214929 |  |
IC50 | = | 7.0 | nM | 265.32 | NCCNc1nc(-c2ccncc2)cc2cnccc12 | Homo sapiens | CHEMBL3387550 | single protein format |
| CHEMBL2147538 |  |
IC50 | = | 35.0 | nM | 293.37 | CC(C)(N)CNc1nc(-c2ccncc2)cc2cnccc12 | Homo sapiens | CHEMBL3387550 | single protein format |
| CHEMBL3338837 |  |
IC50 | = | 99.0 | nM | 294.36 | CC(C)(N)CNc1nc(-c2ccncc2)nc2cnccc12 | Homo sapiens | CHEMBL3387550 | single protein format |
| CHEMBL5182936 |  |
IC50 | = | 120.0 | nM | 255.32 | CCCn1c(-c2ccncc2)cc2c1CCNC2=O | Homo sapiens | CHEMBL5134828 | single protein format |
| CHEMBL250870 |  |
IC50 | = | 210.0 | nM | 241.29 | CCn1c(-c2ccncc2)cc2c1CCNC2=O | Homo sapiens | CHEMBL5134828 | single protein format |
| CHEMBL4568087 |  |
IC50 | = | 250.0 | nM | 421.53 | Cn1cc(-c2cnc3c(-c4csc(C(=O)N[C@@H]5CCCC[C@@H]5N)c4)cnn3c2)cn1 | Homo sapiens | CHEMBL4479766 | assay format |
| CHEMBL225519 |  |
IC50 | = | 300.0 | nM | 213.24 | O=C1NCCc2[nH]c(-c3ccncc3)cc21 | Homo sapiens | CHEMBL5134828 | single protein format |
| CHEMBL1945559 |  |
IC50 | = | 310.0 | nM | 363.25 | Cn1c2c(c3ccc(Cl)c(Cl)c31)C(C#N)C1(CCNCC1)NC2=O | Homo sapiens | CHEMBL1947861 | single protein format |
| CHEMBL250871 |  |
IC50 | = | 440.0 | nM | 257.29 | O=C1NCCc2c1cc(-c1ccncc1)n2CCO | Homo sapiens | CHEMBL5134828 | single protein format |
| CHEMBL5175087 |  |
IC50 | = | 520.0 | nM | 289.34 | O=C1NC(c2ccccc2)Cc2[nH]c(-c3ccncc3)cc21 | Homo sapiens | CHEMBL5134828 | single protein format |
| CHEMBL3338838 |  |
IC50 | = | 547.0 | nM | 333.4 | CC(C)(N)CNc1nc(-c2ccc3[nH]ncc3c2)nc2cnccc12 | Homo sapiens | CHEMBL3387550 | single protein format |
| CHEMBL3338840 |  |
IC50 | = | 990.0 | nM | 330.4 | c1ccc2c(N3CCNCC3)nc(-c3ccc4[nH]ncc4c3)nc2c1 | Homo sapiens | CHEMBL3387550 | single protein format |
| CHEMBL5182936 | |
Ki | = | 60.0 | nM | 255.32 | CCCn1c(-c2ccncc2)cc2c1CCNC2=O | Homo sapiens | CHEMBL5134827 | single protein format |
| CHEMBL250870 | |
Ki | = | 108.0 | nM | 241.29 | CCn1c(-c2ccncc2)cc2c1CCNC2=O | Homo sapiens | CHEMBL5134827 | single protein format |
| CHEMBL225519 | |
Ki | = | 150.0 | nM | 213.24 | O=C1NCCc2[nH]c(-c3ccncc3)cc21 | Homo sapiens | CHEMBL5134827 | single protein format |
| CHEMBL250871 | |
Ki | = | 220.0 | nM | 257.29 | O=C1NCCc2c1cc(-c1ccncc1)n2CCO | Homo sapiens | CHEMBL5134827 | single protein format |
| CHEMBL5175087 | |
Ki | = | 260.0 | nM | 289.34 | O=C1NC(c2ccccc2)Cc2[nH]c(-c3ccncc3)cc21 | Homo sapiens | CHEMBL5134827 | single protein format |
| CHEMBL1990482 |  |
Ki | = | 540.0 | nM | 238.25 | NC(=O)c1cccc2[nH]c(-c3ccncc3)nc12 | Homo sapiens | CHEMBL4628249 | single protein format |