Q15910 | EZH2_HUMAN | Histone-lysine N-methyltransferase EZH2 (EZH2)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00856 | SET - SET domain | 623~726 | |
| PF11616 | EZH2_WD-Binding - WD repeat binding protein EZH2 | 39~68 | |
| PF18118 | PRC2_HTH_1 - Polycomb repressive complex 2 tri-helical domain | 158~249 | |
| PF18264 | preSET_CXC - CXC domain | 559~590 | |
| PF21358 | Ezh2_MCSS - Ezh2, MCSS domain | 257~309 |
3D structures mapped by conservation among orthologs
[ Domain: "SET domain-like" // SET ]
[ Domain: "tri-helical" // KOG1079_1st ]
[ Domain: "tri-helical" // Myb_DNA-binding_3 ]
[ Domain: "Zn3Cys9 preSET domain-related" // KOG1079_4th ]
[ Domain: "Zn3Cys9 preSET domain-related" // KOG1079_3rd ]
[ Domain: "Ezh2 MCSS domain" // KOG1079_2nd ]
[ Domain: "Ezh2 N-terminal domain" // EZH2_WD-Binding ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL5188827 |  |
IC50 | = | 0.01 | nM | 541.7 | CCCc1cc(C)[nH]c(=O)c1CNC(=O)c1cc(-c2ccc(N3CCOCC3)nc2)c2ccn(C(C)C)c2c1C | Homo sapiens | CHEMBL5123926 | single protein format |
| CHEMBL5172110 |  |
IC50 | = | 0.028 | nM | 546.13 | CSc1cc(C)[nH]c(=O)c1CN1CCc2c(Cl)c3c(c(C)c2C1=O)O[C@@](C)([C@H]1CC[C@H](N(C)C)CC1)O3 | Homo sapiens | CHEMBL5123926 | single protein format |
| CHEMBL5178022 |  |
IC50 | = | 0.038 | nM | 520.1 | CSc1cc(C)[nH]c(=O)c1CNC(=O)c1cc(Cl)c2c(c1C)O[C@@](C)([C@H]1CC[C@H](N(C)C)CC1)O2 | Homo sapiens | CHEMBL5123926 | single protein format |
| CHEMBL5206526 |  |
IC50 | = | 0.039 | nM | 576.52 | Cc1cc(Cl)c(CNC(=O)c2cc(Cl)c3c(c2C)OC(C)(C2CCC(N4CC(OC5CC5)C4)CC2)O3)c(=O)[nH]1 | Homo sapiens | CHEMBL5123926 | single protein format |
| CHEMBL5188476 |  |
IC50 | = | 0.057 | nM | 562.78 | CSc1cc(C)[nH]c(=O)c1CNC(=O)c1c(C)n([C@@H](C)[C@H]2CC[C@H](N3CC(OC4CC4)C3)CC2)c2ccccc12 | Homo sapiens | CHEMBL5138242 | single protein format |
| CHEMBL4639983 |  |
IC50 | = | 0.057 | nM | 563.77 | CSc1cc(C)[nH]c(=O)c1CNC(=O)c1c(C)n([C@H](C)[C@H]2CC[C@H](N3CC(OC4CC4)C3)CC2)c2ncccc12 | Homo sapiens | CHEMBL4618933 | cell-based format |
| CHEMBL4640994 |  |
IC50 | = | 0.059 | nM | 536.74 | COC1CN([C@H]2CC[C@H]([C@@H](C)n3c(C)c(C(=O)NCc4c(SC)cc(C)[nH]c4=O)c4ccccc43)CC2)C1 | Homo sapiens | CHEMBL4618933 | cell-based format |
| CHEMBL4638754 |  |
IC50 | = | 0.06 | nM | 581.76 | CSc1cc(C)[nH]c(=O)c1CNC(=O)c1c(C)n([C@H](C)[C@H]2CC[C@H](N3CC(OC4CC4)C3)CC2)c2ncc(F)cc12 | Homo sapiens | CHEMBL4618933 | cell-based format |
| CHEMBL4637572 |  |
IC50 | = | 0.063 | nM | 580.77 | CSc1cc(C)[nH]c(=O)c1CNC(=O)c1c(C)n([C@H](C)[C@H]2CC[C@H](N3CC(OC4CC4)C3)CC2)c2c(F)cccc12 | Homo sapiens | CHEMBL4618933 | cell-based format |
| CHEMBL4635809 |  |
IC50 | = | 0.067 | nM | 524.73 | CSc1cc(C)[nH]c(=O)c1CNC(=O)c1c(C)n([C@H](C)C2CCN(CC(C)(C)O)CC2)c2ccccc12 | Homo sapiens | CHEMBL4618933 | cell-based format |
| CHEMBL4635863 |  |
IC50 | = | 0.072 | nM | 562.78 | CSc1cc(C)[nH]c(=O)c1CNC(=O)c1c(C)n([C@H](C)[C@H]2CC[C@H](N3CC(OC4CC4)C3)CC2)c2ccccc12 | Homo sapiens | CHEMBL4618933 | cell-based format |
| CHEMBL4635102 |  |
IC50 | = | 0.092 | nM | 598.21 | CSc1cc(C)[nH]c(=O)c1CNC(=O)c1c(C)n([C@H](C)[C@H]2CC[C@H](N3CC(OC4CC4)C3)CC2)c2ncc(Cl)cc12 | Homo sapiens | CHEMBL4618933 | cell-based format |
| CHEMBL4633923 |  |
IC50 | = | 0.1 | nM | 564.76 | CSc1cc(C)[nH]c(=O)c1CNC(=O)c1c(C)n([C@H](C)[C@H]2CC[C@H](N3CC(OC4CC4)C3)CC2)c2ncncc12 | Homo sapiens | CHEMBL4618933 | cell-based format |
| CHEMBL4639913 |  |
IC50 | = | 0.1 | nM | 572.72 | CSc1cc(C)[nH]c(=O)c1CNC(=O)c1c(C)n([C@H](C)[C@H]2CC[C@H](N3CC(OC(F)F)C3)CC2)c2ccccc12 | Homo sapiens | CHEMBL4618933 | cell-based format |
| CHEMBL4633932 |  |
IC50 | = | 0.12 | nM | 508.69 | CSc1cc(C)[nH]c(=O)c1CNC(=O)c1c(C)n([C@H](C)C2CCN(C3COC3)CC2)c2ccccc12 | Homo sapiens | CHEMBL4618933 | cell-based format |
| CHEMBL4634677 |  |
IC50 | = | 0.13 | nM | 522.72 | CSc1cc(C)[nH]c(=O)c1CNC(=O)c1c(C)n([C@H](C)[C@H]2CC[C@H](NC3COC3)CC2)c2ccccc12 | Homo sapiens | CHEMBL4618933 | cell-based format |
| CHEMBL4637958 |  |
IC50 | = | 0.14 | nM | 590.71 | CSc1cc(C)[nH]c(=O)c1CNC(=O)c1c(C)n([C@H](C)[C@H]2CC[C@H](N3CC(OC(F)(F)F)C3)CC2)c2ccccc12 | Homo sapiens | CHEMBL4618933 | cell-based format |
| CHEMBL4649131 |  |
IC50 | = | 0.16 | nM | 498.65 | CSc1cc(C)[nH]c(=O)c1CNC(=O)c1c(C)n([C@H](C)[C@H]2OC[C@H](N(C)C)CO2)c2ccccc12 | Homo sapiens | CHEMBL4618933 | cell-based format |
| CHEMBL4639569 |  |
IC50 | = | 0.18 | nM | 542.7 | CSc1cc(C)[nH]c(=O)c1CNC(=O)c1c(C)n([C@H](C)[C@H]2CC[C@@H](N3CC(F)(F)C3)CC2)c2ccccc12 | Homo sapiens | CHEMBL4618933 | cell-based format |
| CHEMBL4639616 |  |
IC50 | = | 0.18 | nM | 534.65 | CSc1cc(C)[nH]c(=O)c1CNC(=O)c1c(C)n([C@H](C)C2CCN(CC(F)(F)F)CC2)c2ccccc12 | Homo sapiens | CHEMBL4618933 | cell-based format |