Q15858 | SCN9A_HUMAN | Sodium channel protein type 9 subunit alpha (SCN9A)
Pfam Domain Table
Accession | Domain | Range | Color |
---|---|---|---|
PF00520 | Ion_trans - Ion transport protein | 125~410 | |
PF00520 | Ion_trans - Ion transport protein | 744~975 | |
PF00520 | Ion_trans - Ion transport protein | 1191~1466 | |
PF00520 | Ion_trans - Ion transport protein | 1515~1770 | |
PF06512 | Na_trans_assoc - Sodium ion transport-associated | 982~1187 | |
PF11933 | Na_trans_cytopl - Cytoplasmic domain of voltage-gated Na+ ion channel | 535~694 | |
PF24609 | IQ_SCN5A_C - SCN5A-like, C-terminal IQ motif | 1882~1913 |
3D structures mapped by conservation among orthologs
[ Domain: "Voltage-gated ion channels" // Ion_trans ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
---|---|---|---|---|---|---|---|---|---|---|
CHEMBL4640389 | IC50 | = | 0.11 | nM | 530.5 | O=S(=O)(Nc1ccncn1)c1ccc2c(c1)OCC[C@@H]2c1ccc(C(F)(F)F)cc1-c1ccc(F)nc1 | Homo sapiens | CHEMBL4629712 | cell-based format | |
CHEMBL3955386 | IC50 | = | 0.2 | nM | 564.0 | CN(C)c1noc2ccc(-c3cc(Cl)ccc3Oc3cc(F)c(S(=O)(=O)Nc4ncns4)cc3F)cc12 | Homo sapiens | CHEMBL3889237 | cell-based format | |
CHEMBL3965272 | IC50 | = | 0.3 | nM | 536.93 | O=c1[nH]c2cc(-c3cc(Cl)ccc3Oc3cc(F)c(S(=O)(=O)Nc4ncns4)cc3F)ccc2o1 | Homo sapiens | CHEMBL3889237 | cell-based format | |
CHEMBL3657851 | IC50 | = | 0.3 | nM | 421.53 | CS(=O)(=O)NC(=O)c1cc(C2CC2)c(OCC23CC4CC(CC(C4)C2)C3)cc1F | Homo sapiens | CHEMBL3707743 | cell-based format | |
CHEMBL4646742 | IC50 | = | 0.4 | nM | 520.56 | Cn1nccc1-c1cc(C(F)(F)F)ccc1[C@H]1CCOc2cc(S(=O)(=O)Nc3nccs3)ccc21 | Homo sapiens | CHEMBL4629712 | cell-based format | |
CHEMBL3657855 | IC50 | = | 0.4 | nM | 462.59 | O=C(NS(=O)(=O)N1CCC1)c1cc(C2CC2)c(OCC23CC4CC(CC(C4)C2)C3)cc1F | Homo sapiens | CHEMBL3707743 | cell-based format | |
CHEMBL4634421 | IC50 | = | 0.4 | nM | 535.54 | O=S(=O)(Nc1nccs1)c1ccc2c(c1)OCC[C@@H]2c1ccc(C(F)(F)F)cc1-c1ccc(F)nc1 | Homo sapiens | CHEMBL4629712 | cell-based format | |
CHEMBL4642748 | IC50 | = | 0.5 | nM | 507.52 | O=S(=O)(Nc1nccs1)c1ccc2c(c1)OCC[C@@H]2c1ccc(C(F)(F)F)cc1-n1ccnn1 | Homo sapiens | CHEMBL4629712 | cell-based format | |
CHEMBL4636838 | IC50 | = | 0.5 | nM | 534.56 | O=S(=O)(Nc1nccs1)c1ccc2c(c1)OCC[C@@H]2c1ccc(C(F)(F)F)cc1-c1ccc(F)cc1 | Homo sapiens | CHEMBL4629712 | cell-based format | |
CHEMBL4282994 | IC50 | = | 0.5 | nM | 554.54 | O=S(=O)(Nc1ccncn1)c1cc2c(cc1F)[C@@H](N1CC[C@H](C(F)(F)F)C[C@@H]1c1ccc(F)cc1)CCO2 | Homo sapiens | CHEMBL4266780 | single protein format | |
CHEMBL3806065 | IC50 | = | 0.5 | nM | 549.97 | CNc1noc2ccc(-c3cc(Cl)ccc3Oc3cc(F)c(S(=O)(=O)Nc4ncns4)cc3F)cc12 | Homo sapiens | CHEMBL3806691 | cell-based format | |
CHEMBL3957974 | IC50 | = | 0.5 | nM | 535.94 | Nc1noc2ccc(-c3cc(Cl)ccc3Oc3cc(F)c(S(=O)(=O)Nc4ncns4)c(F)c3)cc12 | Homo sapiens | CHEMBL3889237 | cell-based format | |
CHEMBL4444408 | IC50 | = | 0.57 | nM | 524.59 | O=S(=O)(Nc1ncns1)c1ccc2c(c1)OCC[C@@H]2N1CC[C@H](C(F)(F)F)C[C@@H]1c1ccccc1 | Homo sapiens | CHEMBL4386295 | cell-based format | |
CHEMBL3341983 | IC50 | = | 0.6 | nM | 535.94 | Nc1noc2ccc(-c3cc(Cl)ccc3Oc3cc(F)c(S(=O)(=O)Nc4ncns4)cc3F)cc12 | Homo sapiens | CHEMBL3368016 | single protein format | |
CHEMBL4633361 | IC50 | = | 0.6 | nM | 532.52 | Cn1nccc1-c1cc(C(F)(F)F)ccc1[C@H]1CCOc2cc(S(=O)(=O)Nc3cccc(F)n3)ccc21 | Homo sapiens | CHEMBL4629712 | cell-based format | |
CHEMBL3910564 | IC50 | = | 0.7 | nM | 516.51 | Cc1ccc(Oc2cc(F)c(S(=O)(=O)Nc3ncns3)cc2F)c(-c2ccc3oc(=O)[nH]c3c2)c1 | Homo sapiens | CHEMBL3889237 | cell-based format | |
CHEMBL4649638 | IC50 | = | 0.8 | nM | 524.59 | O=S(=O)(Nc1nccs1)c1ccc2c(c1)OCC[C@@H]2c1ccc(C(F)(F)F)cc1N1CCNCC1 | Homo sapiens | CHEMBL4629712 | cell-based format | |
CHEMBL3925113 | IC50 | = | 0.8 | nM | 535.94 | Nc1nc2ccc(-c3cc(Cl)ccc3Oc3cc(F)c(S(=O)(=O)Nc4ncns4)cc3F)cc2o1 | Homo sapiens | CHEMBL3889237 | cell-based format | |
CHEMBL3325528 | IC50 | = | 0.9 | nM | 518.97 | O=S(=O)(Nc1ncns1)c1cc(F)c(OC[C@H]2CNCC[C@@H]2c2ccc(Cl)c(F)c2)cc1F | Homo sapiens | CHEMBL3390669 | cell-based format | |
CHEMBL3617062 | IC50 | = | 0.9 | nM | 518.97 | O=S(=O)(Nc1ncns1)c1cc(F)c(OC[C@@H]2CNCC[C@H]2c2ccc(Cl)c(F)c2)cc1F | Homo sapiens | CHEMBL3618957 | cell-based format |