Q15858 | SCN9A_HUMAN | Sodium channel protein type 9 subunit alpha (SCN9A)

Pfam Domain Table

AccessionDomainRangeColor
PF00520Ion_trans - Ion transport protein125~410
PF00520Ion_trans - Ion transport protein744~975
PF00520Ion_trans - Ion transport protein1191~1466
PF00520Ion_trans - Ion transport protein1515~1770
PF06512Na_trans_assoc - Sodium ion transport-associated982~1187
PF11933Na_trans_cytopl - Cytoplasmic domain of voltage-gated Na+ ion channel535~694
PF24609IQ_SCN5A_C - SCN5A-like, C-terminal IQ motif1882~1913

3D structures mapped by conservation among orthologs

[ Domain: "Voltage-gated ion channels" // Ion_trans ]

 PyMOL session


[ Alpha Fold Model ] (go)



Known binders annotated in ChEMBL

 IC50 CSV    Ki CSV
Only the first 20 rows are shown.
molecule_chembl_idstructureassay_typerelation valueunitmol_wtsmilesorganism assay_chembl_idbao_label
CHEMBL4640389 IC50 = 0.11 nM 530.5 O=S(=O)(Nc1ccncn1)c1ccc2c(c1)OCC[C@@H]2c1ccc(C(F)(F)F)cc1-c1ccc(F)nc1 Homo sapiens CHEMBL4629712 cell-based format
CHEMBL3955386 IC50 = 0.2 nM 564.0 CN(C)c1noc2ccc(-c3cc(Cl)ccc3Oc3cc(F)c(S(=O)(=O)Nc4ncns4)cc3F)cc12 Homo sapiens CHEMBL3889237 cell-based format
CHEMBL3965272 IC50 = 0.3 nM 536.93 O=c1[nH]c2cc(-c3cc(Cl)ccc3Oc3cc(F)c(S(=O)(=O)Nc4ncns4)cc3F)ccc2o1 Homo sapiens CHEMBL3889237 cell-based format
CHEMBL3657851 IC50 = 0.3 nM 421.53 CS(=O)(=O)NC(=O)c1cc(C2CC2)c(OCC23CC4CC(CC(C4)C2)C3)cc1F Homo sapiens CHEMBL3707743 cell-based format
CHEMBL4646742 IC50 = 0.4 nM 520.56 Cn1nccc1-c1cc(C(F)(F)F)ccc1[C@H]1CCOc2cc(S(=O)(=O)Nc3nccs3)ccc21 Homo sapiens CHEMBL4629712 cell-based format
CHEMBL3657855 IC50 = 0.4 nM 462.59 O=C(NS(=O)(=O)N1CCC1)c1cc(C2CC2)c(OCC23CC4CC(CC(C4)C2)C3)cc1F Homo sapiens CHEMBL3707743 cell-based format
CHEMBL4634421 IC50 = 0.4 nM 535.54 O=S(=O)(Nc1nccs1)c1ccc2c(c1)OCC[C@@H]2c1ccc(C(F)(F)F)cc1-c1ccc(F)nc1 Homo sapiens CHEMBL4629712 cell-based format
CHEMBL4642748 IC50 = 0.5 nM 507.52 O=S(=O)(Nc1nccs1)c1ccc2c(c1)OCC[C@@H]2c1ccc(C(F)(F)F)cc1-n1ccnn1 Homo sapiens CHEMBL4629712 cell-based format
CHEMBL4636838 IC50 = 0.5 nM 534.56 O=S(=O)(Nc1nccs1)c1ccc2c(c1)OCC[C@@H]2c1ccc(C(F)(F)F)cc1-c1ccc(F)cc1 Homo sapiens CHEMBL4629712 cell-based format
CHEMBL4282994 IC50 = 0.5 nM 554.54 O=S(=O)(Nc1ccncn1)c1cc2c(cc1F)[C@@H](N1CC[C@H](C(F)(F)F)C[C@@H]1c1ccc(F)cc1)CCO2 Homo sapiens CHEMBL4266780 single protein format
CHEMBL3806065 IC50 = 0.5 nM 549.97 CNc1noc2ccc(-c3cc(Cl)ccc3Oc3cc(F)c(S(=O)(=O)Nc4ncns4)cc3F)cc12 Homo sapiens CHEMBL3806691 cell-based format
CHEMBL3957974 IC50 = 0.5 nM 535.94 Nc1noc2ccc(-c3cc(Cl)ccc3Oc3cc(F)c(S(=O)(=O)Nc4ncns4)c(F)c3)cc12 Homo sapiens CHEMBL3889237 cell-based format
CHEMBL4444408 IC50 = 0.57 nM 524.59 O=S(=O)(Nc1ncns1)c1ccc2c(c1)OCC[C@@H]2N1CC[C@H](C(F)(F)F)C[C@@H]1c1ccccc1 Homo sapiens CHEMBL4386295 cell-based format
CHEMBL3341983 IC50 = 0.6 nM 535.94 Nc1noc2ccc(-c3cc(Cl)ccc3Oc3cc(F)c(S(=O)(=O)Nc4ncns4)cc3F)cc12 Homo sapiens CHEMBL3368016 single protein format
CHEMBL4633361 IC50 = 0.6 nM 532.52 Cn1nccc1-c1cc(C(F)(F)F)ccc1[C@H]1CCOc2cc(S(=O)(=O)Nc3cccc(F)n3)ccc21 Homo sapiens CHEMBL4629712 cell-based format
CHEMBL3910564 IC50 = 0.7 nM 516.51 Cc1ccc(Oc2cc(F)c(S(=O)(=O)Nc3ncns3)cc2F)c(-c2ccc3oc(=O)[nH]c3c2)c1 Homo sapiens CHEMBL3889237 cell-based format
CHEMBL4649638 IC50 = 0.8 nM 524.59 O=S(=O)(Nc1nccs1)c1ccc2c(c1)OCC[C@@H]2c1ccc(C(F)(F)F)cc1N1CCNCC1 Homo sapiens CHEMBL4629712 cell-based format
CHEMBL3925113 IC50 = 0.8 nM 535.94 Nc1nc2ccc(-c3cc(Cl)ccc3Oc3cc(F)c(S(=O)(=O)Nc4ncns4)cc3F)cc2o1 Homo sapiens CHEMBL3889237 cell-based format
CHEMBL3325528 IC50 = 0.9 nM 518.97 O=S(=O)(Nc1ncns1)c1cc(F)c(OC[C@H]2CNCC[C@@H]2c2ccc(Cl)c(F)c2)cc1F Homo sapiens CHEMBL3390669 cell-based format
CHEMBL3617062 IC50 = 0.9 nM 518.97 O=S(=O)(Nc1ncns1)c1cc(F)c(OC[C@@H]2CNCC[C@H]2c2ccc(Cl)c(F)c2)cc1F Homo sapiens CHEMBL3618957 cell-based format