Q15759 | MK11_HUMAN | Mitogen-activated protein kinase 11 (MAPK11)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00069 | Pkinase - Protein kinase domain | 27~308 |
3D structures mapped by conservation among orthologs
[ Domain: "Protein kinase" // Pkinase_Tyr ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL303144 |  |
IC50 | = | 0.1 | nM | 505.59 | C[C@H](Nc1cc(-c2c(-c3cccc(C(F)(F)F)c3)nc(C3CCNCC3)n2C)ccn1)c1ccccc1 | Homo sapiens | CHEMBL969398 | single protein format |
| CHEMBL5206328 |  |
IC50 | = | 0.2 | nM | 577.73 | Cc1ccc(-n2nc(C(C)(C)C)cc2NC(=O)N[C@H]2CC[C@@H](Oc3ccc4nnc(C(C)C)n4c3)c3ccccc32)cc1 | Homo sapiens | CHEMBL5167056 | assay format |
| CHEMBL199679 |  |
IC50 | = | 0.25 | nM | 541.47 | CC(C)(C)N1CCC(c2cc(-c3ccc(F)cc3F)c3ccc(=O)n(-c4c(Cl)cccc4Cl)c3c2)CC1 | Homo sapiens | CHEMBL969398 | single protein format |
| CHEMBL258202 |  |
IC50 | = | 1.5 | nM | 346.46 | CC[C@@H](C)Nc1ncc(C(=O)Nc2cc(C(=O)NC)ccc2C)s1 | Homo sapiens | CHEMBL928968 | single protein format |
| CHEMBL221700 |  |
IC50 | = | 2.0 | nM | 567.44 | O=C(NCCCN(c1ccc(=O)n(-c2ccccc2Cl)n1)c1ccccc1Cl)C1CCC(C(F)(F)F)CC1 | Homo sapiens | CHEMBL911325 | single protein format |
| CHEMBL2401979 |  |
IC50 | = | 4.0 | nM | 443.43 | Cc1ccc(C(=O)NC2CC2)cc1NC(=O)c1cnn(-c2ncccc2C(F)(F)F)c1C | Homo sapiens | CHEMBL2405972 | single protein format |
| CHEMBL1082158 |  |
IC50 | = | 4.0 | nM | 440.84 | O=C(NC1CC1)c1ccc(Cl)c(Nc2nncc3c2cnn3-c2c(F)cccc2F)c1 | Homo sapiens | CHEMBL1099701 | single protein format |
| CHEMBL103667 |  |
IC50 | = | 7.0 | nM | 527.67 | Cc1ccc(-n2nc(C(C)(C)C)cc2NC(=O)Nc2ccc(OCCN3CCOCC3)c3ccccc23)cc1 | Homo sapiens | CHEMBL1931520 | single protein format |
| CHEMBL88486 |  |
IC50 | = | 8.1 | nM | 376.46 | C[S+]([O-])c1ccc(-c2cc(-c3ccncc3)c(-c3ccc(F)cc3)[nH]2)cc1 | Homo sapiens | CHEMBL737061 | single protein format |
| CHEMBL1290404 |  |
IC50 | = | 10.0 | nM | 375.43 | Cc1ccc(C(=O)NC2CC2)cc1NC(=O)c1cnn(-c2ccccc2)c1N | Homo sapiens | CHEMBL4324175 | assay format |
| CHEMBL316275 |  |
IC50 | = | 10.0 | nM | 392.45 | CS(=O)(=O)c1ccc(-c2cc(-c3ccncc3)c(-c3ccc(F)cc3)[nH]2)cc1 | Homo sapiens | CHEMBL737061 | single protein format |
| CHEMBL412281 |  |
IC50 | = | 12.0 | nM | 387.45 | CNC(=O)c1ccc(C)c(Nc2nc(NC)nc3c2cnn3-c2ccccc2)c1 | Homo sapiens | CHEMBL922523 | single protein format |
| CHEMBL252128 |  |
IC50 | = | 15.0 | nM | 382.42 | CCNC(=O)c1cn2ncnc(Nc3cc(C(=O)NOC)ccc3C)c2c1C | Homo sapiens | CHEMBL926218 | single protein format |
| CHEMBL221547 |  |
IC50 | = | 15.0 | nM | 519.39 | O=C1c2ccccc2C(=O)N1CCCN(c1ccc(=O)n(-c2ccccc2Cl)n1)c1ccccc1Cl | Homo sapiens | CHEMBL911325 | single protein format |
| CHEMBL14212 |  |
IC50 | = | 15.2 | nM | 443.53 | Cc1cccc(Oc2nccc(-c3c(-c4ccc(F)cc4)ncn3C3CCNCC3)n2)c1C | Homo sapiens | CHEMBL5253685 | single protein format |
| CHEMBL2316207 |  |
IC50 | = | 16.9 | nM | 592.67 | O=C(NCCN1CCOCC1)c1ccc2c(c1)C(=O)c1ccc(Nc3ccc(F)c(NC(=O)c4ccccc4)c3)cc1CC2 | Homo sapiens | CHEMBL4883790 | single protein format |
| CHEMBL4756586 |  |
IC50 | = | 17.0 | nM | 530.67 | CCNC(=O)[C@H](CCC1CCCCC1)NC(=O)c1ccc(CNC(=O)c2cnn(-c3ccccc3)c2N)cc1 | Homo sapiens | CHEMBL4711722 | cell-based format |
| CHEMBL2401978 |  |
IC50 | = | 18.0 | nM | 411.91 | Cc1ccc(C(=O)NC2CC2)cc1NC(=O)c1cnc(-c2ccccc2Cl)s1 | Homo sapiens | CHEMBL2405978 | assay format |
| CHEMBL1807446 |  |
IC50 | = | 19.0 | nM | 425.49 | Cc1ccc(C(=O)NC2CC2)cc1Nc1ncnn2cc(C(=O)c3ccccc3)c(C)c12 | Homo sapiens | CHEMBL1811289 | single protein format |
| CHEMBL221595 |  |
IC50 | = | 20.0 | nM | 537.38 | O=C1c2ccccc2C(=O)N1CCCN(c1ccc(=O)n(-c2ccccc2Cl)n1)c1ccc(F)cc1Cl | Homo sapiens | CHEMBL911325 | single protein format |