Q15746 | MYLK_HUMAN | Myosin light chain kinase, smooth muscle (MYLK)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00041 | fn3 - Fibronectin type III domain | 1333~1420 | |
| PF00069 | Pkinase - Protein kinase domain | 1464~1719 | |
| PF07679 | I-set - Immunoglobulin I-set domain | 33~123 | |
| PF07679 | I-set - Immunoglobulin I-set domain | 161~250 | |
| PF07679 | I-set - Immunoglobulin I-set domain | 414~504 | |
| PF07679 | I-set - Immunoglobulin I-set domain | 514~600 | |
| PF07679 | I-set - Immunoglobulin I-set domain | 624~712 | |
| PF07679 | I-set - Immunoglobulin I-set domain | 722~809 | |
| PF07679 | I-set - Immunoglobulin I-set domain | 1098~1187 | |
| PF07679 | I-set - Immunoglobulin I-set domain | 1238~1327 | |
| PF07679 | I-set - Immunoglobulin I-set domain | 1809~1899 | |
| PF16620 | 23ISL - Unstructured linker between I-set domains 2 and 3 on MYLCK | 267~411 |
3D structures mapped by conservation among orthologs
[ Domain: "Immunoglobulin/Fibronectin type III/E set domains/PapD-like" // I-set_1 ]
[ Domain: "Immunoglobulin/Fibronectin type III/E set domains/PapD-like" // I-set ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL3218297 |  |
IC50 | = | 15.63 | nM | 422.49 | CS(=O)(=O)O.O=C(NCc1cccc(O)c1)Nc1nc(-c2ccncc2)cs1 | Homo sapiens | CHEMBL3224487 | single protein format |
| CHEMBL155929 |  |
IC50 | = | 18.0 | nM | 382.47 | Cn1c2ccccc2c2c3c(c4c5ccccc5n(CCCN)c4c21)CNC3=O | Homo sapiens | CHEMBL747420 | single protein format |
| CHEMBL281948 |  |
IC50 | = | 22.0 | nM | 467.48 | COC(=O)[C@@]1(O)C[C@H]2O[C@]1(C)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 | Homo sapiens | CHEMBL708209 | single protein format |
| CHEMBL94678 |  |
IC50 | = | 25.0 | nM | 467.48 | COC(=O)[C@]1(O)C[C@H]2O[C@]1(C)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 | Homo sapiens | CHEMBL708209 | single protein format |
| CHEMBL348563 |  |
IC50 | = | 30.0 | nM | 410.43 | Cn1c2ccc(O)cc2c2c3c(c4c5cc(O)ccc5n(CCC#N)c4c21)CNC3=O | Homo sapiens | CHEMBL747420 | single protein format |
| CHEMBL156433 |  |
IC50 | = | 32.0 | nM | 436.47 | COc1ccc2c(c1)c1c3c(c4c5ccccc5n(C)c4c1n2CCCC#N)C(=O)NC3=O | Homo sapiens | CHEMBL747420 | single protein format |
| CHEMBL388978 |  |
IC50 | = | 40.0 | nM | 466.54 | CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 | Homo sapiens | CHEMBL841528 | single protein format |
| CHEMBL347154 |  |
IC50 | = | 49.0 | nM | 422.44 | COc1ccc2c(c1)c1c3c(c4c5ccccc5n(CCC#N)c4c1n2C)C(=O)NC3=O | Homo sapiens | CHEMBL747420 | single protein format |
| CHEMBL348177 |  |
IC50 | = | 55.0 | nM | 392.42 | Cn1c2ccccc2c2c3c(c4c5ccccc5n(CCC#N)c4c21)C(=O)NC3=O | Homo sapiens | CHEMBL747420 | single protein format |
| CHEMBL157822 |  |
IC50 | = | 120.0 | nM | 470.53 | COc1ccc2c(c1)c1c3c(c4c5ccccc5n(C)c4c1n2CC(O)CN(C)C)C(=O)NC3=O | Homo sapiens | CHEMBL747420 | single protein format |
| CHEMBL156172 |  |
IC50 | = | 120.0 | nM | 440.5 | CN(C)CC(O)Cn1c2ccccc2c2c3c(c4c5ccccc5n(C)c4c21)C(=O)NC3=O | Homo sapiens | CHEMBL747420 | single protein format |
| CHEMBL428496 |  |
IC50 | = | 170.0 | nM | 428.44 | COC[C@H]1OC(=O)c2coc3c2[C@@]1(C)C1=C(C3=O)[C@@H]2CCC(=O)[C@@]2(C)C[C@H]1OC(C)=O | Homo sapiens | CHEMBL1646347 | single protein format |
| CHEMBL348902 |  |
IC50 | = | 180.0 | nM | 452.47 | COc1ccc2c(c1)c1c3c(c4c5cc(OC)ccc5n(CCC#N)c4c1n2C)C(=O)NC3=O | Homo sapiens | CHEMBL747420 | single protein format |
| CHEMBL345593 |  |
IC50 | = | 200.0 | nM | 422.44 | COc1ccc2c(c1)c1c3c(c4c5ccccc5n(C)c4c1n2CCC#N)C(=O)NC3=O | Homo sapiens | CHEMBL747420 | single protein format |
| CHEMBL157967 |  |
IC50 | = | 220.0 | nM | 456.55 | COc1ccc2[nH]c3c(c4c(c5c6cc(OC)ccc6n(CCCN(C)C)c35)CNC4=O)c2c1 | Homo sapiens | CHEMBL747420 | single protein format |
| CHEMBL157892 |  |
IC50 | = | 250.0 | nM | 410.52 | CN(C)CCCn1c2ccccc2c2c3c(c4c5ccccc5n(C)c4c21)C(=O)NC3 | Homo sapiens | CHEMBL747420 | single protein format |
| CHEMBL5174830 |  |
IC50 | = | 265.0 | nM | 331.42 | CN(C)CC#Cc1ccc2[nH]c3c(c2c1)-c1nc(N)ncc1CCC3 | Homo sapiens | CHEMBL5111461 | cell-based format |
| CHEMBL157528 |  |
IC50 | = | 310.0 | nM | 428.49 | CN(C)CCCn1c2ccc(O)cc2c2c3c(c4c5cc(O)ccc5[nH]c4c21)C(=O)NC3 | Homo sapiens | CHEMBL747420 | single protein format |
| CHEMBL5093741 |  |
IC50 | = | 334.0 | nM | 468.44 | CN1Cc2nn(C)c(C#N)c2-c2cnc3[nH]cc(c3c2)-c2cn(nc2C(F)(F)F)CCCC1=O | Homo sapiens | CHEMBL5046163 | single protein format |
| CHEMBL154245 |  |
IC50 | = | 390.0 | nM | 396.49 | CN(C)CCCn1c2ccccc2c2c3c(c4c5ccccc5[nH]c4c21)C(=O)NC3 | Homo sapiens | CHEMBL747420 | single protein format |