Q15393 | SF3B3_HUMAN | Splicing factor 3B subunit 3 (SF3B3)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF03178 | CPSF_A - CPSF A subunit region | 863~1183 | |
| PF10433 | Beta-prop_RSE1_1st - RSE1/DDB1/CPSF1 first beta-propeller | 14~401 | |
| PF23726 | Beta-prop_RSE1_2nd - RSE1/DDB1/CPSF1 second beta-propeller | 439~765 |
3D structures mapped by conservation among orthologs
[ Domain: "7-bladed" // CPSF_A_N ]
[ Domain: "7-bladed" // MMS1_N_C ]
[ Domain: "7-bladed" // MMS1_N_N ]
[ Domain: "tri-helical" // CPSF_A_C ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL1242745 |  |
IC50 | = | 1.3 | nM | 538.72 | CC[C@H](O)[C@@H](C)[C@H]1O[C@@H]1C[C@H](C)/C=C/C=C(\C)[C@H]1OC(=O)C[C@H](O)CC[C@@](C)(O)[C@@H](OC(C)=O)CC[C@@H]1C | Homo sapiens | CHEMBL1243914 | cell-based format |
| CHEMBL1242564 |  |
IC50 | = | 3.3 | nM | 554.72 | CC[C@H](O)[C@@H](C)[C@H]1O[C@@H]1C[C@@](C)(O)/C=C/C=C(\C)[C@H]1OC(=O)C[C@H](O)CC[C@@](C)(O)[C@@H](OC(C)=O)CC[C@@H]1C | Homo sapiens | CHEMBL1243914 | cell-based format |
| CHEMBL1242467 |  |
IC50 | = | 5.0 | nM | 536.71 | CCC(=O)[C@@H](C)[C@H]1O[C@@H]1C[C@H](C)/C=C/C=C(\C)[C@H]1OC(=O)C[C@H](O)CC[C@@](C)(O)[C@@H](OC(C)=O)CC[C@@H]1C | Homo sapiens | CHEMBL1243914 | cell-based format |
| CHEMBL1242284 |  |
IC50 | = | 6.6 | nM | 567.76 | CCNC(=O)O[C@H]1CC[C@H](C)[C@@H](/C(C)=C/C=C/[C@@H](C)C[C@H]2O[C@@H]2[C@H](C)[C@@H](O)CC)OC(=O)C[C@H](O)CC[C@@]1(C)O | Homo sapiens | CHEMBL1243914 | cell-based format |
| CHEMBL1242654 |  |
IC50 | = | 58.9 | nM | 554.72 | CC[C@H](O)[C@](C)(O)[C@H]1O[C@@H]1C[C@H](C)/C=C/C=C(\C)[C@H]1OC(=O)C[C@H](O)CC[C@@](C)(O)[C@@H](OC(C)=O)CC[C@@H]1C | Homo sapiens | CHEMBL1243914 | cell-based format |
| CHEMBL1242841 |  |
IC50 | = | 307.7 | nM | 496.69 | CC[C@H](O)[C@@H](C)[C@H]1O[C@@H]1C[C@H](C)/C=C/C=C(\C)[C@H]1OC(=O)C[C@H](O)CC[C@@](C)(O)[C@@H](O)CC[C@@H]1C | Homo sapiens | CHEMBL1243914 | cell-based format |
| CHEMBL99 |  |
IC50 | = | 611.2 | nM | 302.37 | CC(/C=C/C(=O)NO)=C\[C@@H](C)C(=O)c1ccc(N(C)C)cc1 | Homo sapiens | CHEMBL1243914 | cell-based format |