Q15391 | P2Y14_HUMAN | P2Y purinoceptor 14 (P2RY14)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00001 | 7tm_1 - 7 transmembrane receptor (rhodopsin family) | 57~295 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL4743495 |  |
IC50 | = | 0.5 | nM | 511.97 | Cl.O=C(O)c1cc(-c2ccc(C3CCNCC3)cc2)c2ccc(-c3ccc(C(F)(F)F)cc3)cc2c1 | Homo sapiens | CHEMBL5210552 | single protein format |
| CHEMBL5085823 |  |
IC50 | = | 3.11 | nM | 487.52 | O=C(O)c1cc(-c2ccc([C@H]3C[C@H]4C[C@@H]3CN4)cc2)c2ccc(-c3ccc(C(F)(F)F)cc3)cc2c1 | Homo sapiens | CHEMBL5045601 | cell-based format |
| CHEMBL5399275 |  |
IC50 | = | 5.92 | nM | 503.52 | O=C(O)c1cc(-c2ccc([C@]3(O)[C@@H]4CNC[C@H]3C4)cc2)c2ccc(-c3ccc(C(F)(F)F)cc3)cc2c1 | Homo sapiens | CHEMBL5334868 | cell-based format |
| CHEMBL1800685 |  |
IC50 | = | 7.96 | nM | 475.51 | O=C(O)c1cc(-c2ccc(C3CCNCC3)cc2)c2ccc(-c3ccc(C(F)(F)F)cc3)cc2c1 | Homo sapiens | CHEMBL4189951 | cell-based format |
| CHEMBL5074765 |  |
IC50 | = | 8.62 | nM | 487.52 | O=C(O)c1cc(-c2ccc([C@@H]3C[C@@H]4C[C@H]3CN4)cc2)c2ccc(-c3ccc(C(F)(F)F)cc3)cc2c1 | Homo sapiens | CHEMBL5045601 | cell-based format |
| CHEMBL5404195 |  |
IC50 | = | 9.48 | nM | 517.55 | O=C(O)c1cc(-c2ccc(C3(O)C[C@H]4CNC[C@@H]4C3)cc2)c2ccc(-c3ccc(C(F)(F)F)cc3)cc2c1 | Homo sapiens | CHEMBL5334868 | cell-based format |
| CHEMBL5417310 |  |
IC50 | = | 9.58 | nM | 489.54 | O=C(O)c1cc(-c2ccc(C3CCCNCC3)cc2)c2ccc(-c3ccc(C(F)(F)F)cc3)cc2c1 | Homo sapiens | CHEMBL5334868 | cell-based format |
| CHEMBL5438846 |  |
IC50 | = | 9.69 | nM | 485.51 | O=C(O)c1cc(-c2ccc(C3=CC4(CNC4)C3)cc2)c2ccc(-c3ccc(C(F)(F)F)cc3)cc2c1 | Homo sapiens | CHEMBL5334868 | cell-based format |
| CHEMBL5087295 |  |
IC50 | = | 9.8 | nM | 487.52 | O=C(O)c1cc(-c2ccc([C@@H]3C[C@H]4CN[C@@H]3C4)cc2)c2ccc(-c3ccc(C(F)(F)F)cc3)cc2c1 | Homo sapiens | CHEMBL5045601 | cell-based format |
| CHEMBL5083619 |  |
IC50 | = | 10.8 | nM | 505.54 | N[C@@H]1C[C@H](CO)[C@@H](c2ccc(-c3cc(C(=O)O)cc4cc(-c5ccc(C(F)(F)F)cc5)ccc34)cc2)C1 | Homo sapiens | CHEMBL5045601 | cell-based format |
| CHEMBL5085145 |  |
IC50 | = | 12.6 | nM | 505.54 | N[C@H]1C[C@@H](CO)[C@H](c2ccc(-c3cc(C(=O)O)cc4cc(-c5ccc(C(F)(F)F)cc5)ccc34)cc2)C1 | Homo sapiens | CHEMBL5045601 | cell-based format |
| CHEMBL4864408 |  |
IC50 | = | 15.0 | nM | 489.45 | O=C(O)c1cc(-c2ccc(-c3cc(CO)on3)cc2)c2ccc(-c3ccc(C(F)(F)F)cc3)cc2c1 | Homo sapiens | CHEMBL4808686 | cell-based format |
| CHEMBL5092515 |  |
IC50 | = | 15.6 | nM | 517.55 | O=C(O)c1cc(-c2ccc([C@@]3(O)C[C@H]4CC[C@@H]3CN4)cc2)c2ccc(-c3ccc(C(F)(F)F)cc3)cc2c1 | Homo sapiens | CHEMBL5045601 | cell-based format |
| CHEMBL5420363 |  |
IC50 | = | 16.6 | nM | 499.53 | O=C(O)c1cc(-c2ccc(C3=C[C@H]4CNC[C@@H]4C3)cc2)c2ccc(-c3ccc(C(F)(F)F)cc3)cc2c1 | Homo sapiens | CHEMBL5334868 | cell-based format |
| CHEMBL5086827 |  |
IC50 | = | 17.8 | nM | 489.54 | CC1CC(c2ccc(-c3cc(C(=O)O)cc4cc(-c5ccc(C(F)(F)F)cc5)ccc34)cc2)CCN1 | Homo sapiens | CHEMBL5045601 | cell-based format |
| CHEMBL4644135 |  |
IC50 | = | 18.0 | nM | 473.49 | O=C(O)c1cc(-c2ccc(C3=CCNCC3)cc2)c2ccc(-c3ccc(C(F)(F)F)cc3)cc2c1 | Homo sapiens | CHEMBL4622293 | cell-based format |
| CHEMBL5432717 |  |
IC50 | = | 18.5 | nM | 503.56 | O=C(O)c1cc(-c2ccc(C3CCCNCCC3)cc2)c2ccc(-c3ccc(C(F)(F)F)cc3)cc2c1 | Homo sapiens | CHEMBL5334868 | cell-based format |
| CHEMBL4645216 |  |
IC50 | = | 20.0 | nM | 501.55 | O=C(O)c1cc(-c2ccc(C34CCN(CC3)CC4)cc2)c2ccc(-c3ccc(C(F)(F)F)cc3)cc2c1 | Homo sapiens | CHEMBL4622293 | cell-based format |
| CHEMBL5416286 |  |
IC50 | = | 20.8 | nM | 503.52 | O=C(O)c1cc(-c2ccc(C3(O)CC4(CNC4)C3)cc2)c2ccc(-c3ccc(C(F)(F)F)cc3)cc2c1 | Homo sapiens | CHEMBL5334868 | cell-based format |
| CHEMBL5078197 |  |
IC50 | = | 20.9 | nM | 489.54 | CC1CNCCC1c1ccc(-c2cc(C(=O)O)cc3cc(-c4ccc(C(F)(F)F)cc4)ccc23)cc1 | Homo sapiens | CHEMBL5045601 | cell-based format |