Q15375 | EPHA7_HUMAN | Ephrin type-A receptor 7 (EPHA7)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00041 | fn3 - Fibronectin type III domain | 333~430 | |
| PF00041 | fn3 - Fibronectin type III domain | 452~530 | |
| PF00536 | SAM_1 - SAM domain (Sterile alpha motif) | 922~985 | |
| PF01404 | Ephrin_lbd - Ephrin receptor ligand binding domain | 34~205 | |
| PF07699 | Ephrin_rec_like - Tyrosine-protein kinase ephrin type A/B receptor-like | 271~308 | |
| PF07714 | PK_Tyr_Ser-Thr - Protein tyrosine and serine/threonine kinase | 633~888 | |
| PF14575 | EphA2_TM - Ephrin type-A receptor 2 transmembrane domain | 560~630 | |
| PF25599 | Ephrin_CRD - Ephrin cysteine rich domain | 208~265 |
3D structures mapped by conservation among orthologs
[ Domain: "Galactose-binding domain-like" // Ephrin_lbd ]
[ Domain: "SAM domain-like" // SAM_1 ]
[ Domain: "Protein kinase" // Pkinase_Tyr ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL1784637 |  |
IC50 | = | 4.2 | nM | 582.63 | CNC(=O)c1ncc(C#Cc2cc(C(=O)Nc3ccc(CN4CCN(CCO)CC4)c(C(F)(F)F)c3)ccc2C)n1C | Homo sapiens | CHEMBL1785579 | single protein format |
| CHEMBL388978 |  |
IC50 | = | 56.3 | nM | 466.54 | CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 | Homo sapiens | CHEMBL4328402 | single protein format |
| CHEMBL4798527 |  |
IC50 | = | 143.0 | nM | 548.57 | Cc1ccc(NC(=O)c2ccc(C)c(C(F)(F)F)c2)cc1C#Cc1nn([C@H]2CC[C@H](O)CC2)c2ncnc(N)c12 | Homo sapiens | CHEMBL4766183 | single protein format |
| CHEMBL4281823 |  |
IC50 | = | 190.0 | nM | 481.48 | CCn1cc(-c2ccc3c(c2)CCN3C(=O)Cc2cccc(OC(F)(F)F)c2)c2c(N)ncnc21 | Homo sapiens | CHEMBL4261408 | single protein format |
| CHEMBL4793380 |  |
IC50 | = | 199.0 | nM | 423.48 | CC(C)(C)c1cc(NC(=O)Nc2ccc(Nc3ncnc4c3OCCCN4)cc2)no1 | Homo sapiens | CHEMBL4767003 | single protein format |
| CHEMBL3715238 |  |
IC50 | = | 665.0 | nM | 419.45 | Nc1ncc(-c2cc([C@H]3[C@@H]4CN(C5COC5)C[C@@H]43)n(CC3CC3)n2)cc1C(F)(F)F | Homo sapiens | CHEMBL4120184 | assay format |
| CHEMBL103667 |  |
IC50 | < | 1000.0 | nM | 527.67 | Cc1ccc(-n2nc(C(C)(C)C)cc2NC(=O)Nc2ccc(OCCN3CCOCC3)c3ccccc23)cc1 | Homo sapiens | CHEMBL4602917 | single protein format |