Q15349 | KS6A2_HUMAN | Ribosomal protein S6 kinase alpha-2 (RPS6KA2)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00069 | Pkinase - Protein kinase domain | 59~318 | |
| PF00069 | Pkinase - Protein kinase domain | 415~672 | |
| PF00433 | Pkinase_C - Protein kinase C terminal domain | 342~378 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL3956539 |  |
IC50 | = | 0.18 | nM | 458.57 | C[C@@H]1NC(=O)c2cc3ccc(C(=O)Nc4nc5ccccc5n4CCCN(C)C)cc3n2[C@@H]1C | Homo sapiens | CHEMBL3887327 | single protein format |
| CHEMBL388978 |  |
IC50 | = | 0.227 | nM | 466.54 | CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 | Homo sapiens | CHEMBL4328597 | single protein format |
| CHEMBL3945993 |  |
IC50 | = | 0.25 | nM | 401.47 | CCn1c(NC(=O)c2ccc3cc4n(c3c2)C(C)(C)CNC4=O)nc2ccccc21 | Homo sapiens | CHEMBL3887327 | single protein format |
| CHEMBL3903528 |  |
IC50 | = | 0.38 | nM | 458.57 | CN(C)CCCn1c(NC(=O)c2ccc3cc4n(c3c2)C(C)(C)CNC4=O)nc2ccccc21 | Homo sapiens | CHEMBL3887327 | single protein format |
| CHEMBL3900064 |  |
IC50 | = | 0.42 | nM | 413.48 | C[C@@H]1NC(=O)c2cc3ccc(C(=O)Nc4cnn(Cc5ccccc5)c4)cc3n2[C@@H]1C | Homo sapiens | CHEMBL3887327 | single protein format |
| CHEMBL3959915 |  |
IC50 | = | 0.59 | nM | 359.39 | CC1CNC(=O)c2cc3ccc(C(=O)Nc4nc5ccccc5[nH]4)cc3n21 | Homo sapiens | CHEMBL3887327 | single protein format |
| CHEMBL3955947 |  |
IC50 | = | 0.6 | nM | 401.47 | CCn1c(NC(=O)c2ccc3cc4n(c3c2)C(C)CCNC4=O)nc2ccccc21 | Homo sapiens | CHEMBL3887327 | single protein format |
| CHEMBL4109143 |  |
IC50 | = | 0.6 | nM | 399.45 | C[C@@H]1CNC(=O)c2cc3ccc(C(=O)Nc4cnn(Cc5ccccc5)c4)cc3n21 | Homo sapiens | CHEMBL3887327 | single protein format |
| CHEMBL3908561 |  |
IC50 | = | 0.62 | nM | 387.44 | Cn1c(NC(=O)c2ccc3cc4n(c3c2)C(C)(C)CNC4=O)nc2ccccc21 | Homo sapiens | CHEMBL3887327 | single protein format |
| CHEMBL3972132 |  |
IC50 | = | 0.63 | nM | 387.44 | CCn1c(NC(=O)c2ccc3cc4n(c3c2)C(C)CNC4=O)nc2ccccc21 | Homo sapiens | CHEMBL3887327 | single protein format |
| CHEMBL4108521 |  |
IC50 | = | 0.64 | nM | 401.47 | CCn1c(NC(=O)c2ccc3cc4n(c3c2)[C@@H](C)[C@@H](C)NC4=O)nc2ccccc21 | Homo sapiens | CHEMBL3887327 | single protein format |
| CHEMBL4113357 |  |
IC50 | = | 0.7 | nM | 444.54 | C[C@@H]1CNC(=O)c2cc3ccc(C(=O)Nc4nc5ccccc5n4CCCN(C)C)cc3n21 | Homo sapiens | CHEMBL3887327 | single protein format |
| CHEMBL4111661 |  |
IC50 | = | 0.71 | nM | 413.48 | C[C@@H]1CCNC(=O)c2cc3ccc(C(=O)Nc4cnn(Cc5ccccc5)c4)cc3n21 | Homo sapiens | CHEMBL3887327 | single protein format |
| CHEMBL3951802 |  |
IC50 | = | 0.77 | nM | 373.42 | CC1CCNC(=O)c2cc3ccc(C(=O)Nc4nc5ccccc5[nH]4)cc3n21 | Homo sapiens | CHEMBL3887327 | single protein format |
| CHEMBL3985027 |  |
IC50 | = | 0.89 | nM | 373.42 | CC1(C)CNC(=O)c2cc3ccc(C(=O)Nc4nc5ccccc5[nH]4)cc3n21 | Homo sapiens | CHEMBL3887327 | single protein format |
| CHEMBL495727 |  |
IC50 | = | 1.0 | nM | 381.44 | O=C(Nc1c[nH]nc1-c1nc2ccc(CN3CCOCC3)cc2[nH]1)NC1CC1 | Homo sapiens | CHEMBL1009904 | single protein format |
| CHEMBL1933280 |  |
IC50 | = | 1.1 | nM | 387.44 | CCn1c(NC(=O)c2ccc3cc4n(c3c2)CCCNC4=O)nc2ccccc21 | Homo sapiens | CHEMBL3887327 | single protein format |
| CHEMBL1933288 |  |
IC50 | = | 1.1 | nM | 458.57 | C[C@@H]1CCNC(=O)c2cc3ccc(C(=O)Nc4nc5ccccc5n4CCCN(C)C)cc3n21 | Homo sapiens | CHEMBL3887327 | single protein format |
| CHEMBL3942136 |  |
IC50 | = | 1.3 | nM | 458.57 | CC1CCNC(=O)c2cc3ccc(C(=O)Nc4nc5ccccc5n4CCCN(C)C)cc3n21 | Homo sapiens | CHEMBL3887327 | single protein format |
| CHEMBL3939884 |  |
IC50 | = | 1.3 | nM | 444.54 | CC1CNC(=O)c2cc3ccc(C(=O)Nc4nc5ccccc5n4CCCN(C)C)cc3n21 | Homo sapiens | CHEMBL3887327 | single protein format |