Q15303 | ERBB4_HUMAN | Receptor tyrosine-protein kinase erbB-4 (ERBB4)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00757 | Furin-like - Furin-like cysteine rich region | 186~335 | |
| PF01030 | Recep_L_domain - Receptor L domain | 55~166 | |
| PF01030 | Recep_L_domain - Receptor L domain | 358~477 | |
| PF07714 | PK_Tyr_Ser-Thr - Protein tyrosine and serine/threonine kinase | 719~973 | |
| PF14843 | GF_recep_IV - Growth factor receptor domain IV | 502~633 | |
| PF21314 | TM_ErbB1 - Epidermal growth factor receptor transmembrane-juxtamembrane segment | 653~688 |
3D structures mapped by conservation among orthologs
[ Domain: "Leucine-rich repeats" // Recep_L_domain ]
[ Domain: "Leucine-rich repeats" // GF_recep_IV,Recep_L_domain ]
[ Domain: "Protein kinase" // Pkinase_Tyr ]
[ Domain: "Growth factor receptor domain" // GF_recep_IV ]
[ Domain: "Growth factor receptor domain" // Furin-like ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL1873475 |  |
IC50 | = | 0.1 | nM | 440.51 | C=CC(=O)N1CCC[C@@H](n2nc(-c3ccc(Oc4ccccc4)cc3)c3c(N)ncnc32)C1 | Homo sapiens | CHEMBL3887535 | single protein format |
| CHEMBL203644 |  |
IC50 | = | 0.5 | nM | 355.76 | CC#CC(=O)Nc1cc2c(Nc3ccc(F)c(Cl)c3)ncnc2cn1 | Homo sapiens | CHEMBL862514 | assay format |
| CHEMBL4211949 |  |
IC50 | = | 0.6 | nM | 423.48 | C=CC(=O)N[C@@H]1Cn2c(c(-c3ccc(Oc4ccccc4)cc3)c3c(N)ncnc32)C1=C | Homo sapiens | CHEMBL4189691 | single protein format |
| CHEMBL437890 |  |
IC50 | = | 0.8 | nM | 512.39 | CN1CCN(CCC#CC(=O)Nc2cc3c(Nc4ccc(F)c(Br)c4)ncnc3cn2)CC1 | Homo sapiens | CHEMBL862514 | assay format |
| CHEMBL204638 |  |
IC50 | = | 1.0 | nM | 499.34 | O=C(C#CCCN1CCOCC1)Nc1cc2c(Nc3ccc(F)c(Br)c3)ncnc2cn1 | Homo sapiens | CHEMBL862514 | assay format |
| CHEMBL203661 |  |
IC50 | = | 1.0 | nM | 454.89 | O=C(C#CCCN1CCOCC1)Nc1cc2c(Nc3ccc(F)c(Cl)c3)ncnc2cn1 | Homo sapiens | CHEMBL862514 | assay format |
| CHEMBL1173655 |  |
IC50 | = | 1.0 | nM | 485.95 | CN(C)C/C=C/C(=O)Nc1cc2c(Nc3ccc(F)c(Cl)c3)ncnc2cc1O[C@H]1CCOC1 | Homo sapiens | CHEMBL4625051 | single protein format |
| CHEMBL3959248 |  |
IC50 | = | 1.0 | nM | 551.65 | COCCOc1cc2ncnc(Nc3ccc4c(cnn4Cc4ccccc4)c3)c2cc1NC(=O)/C=C/CN(C)C | Homo sapiens | CHEMBL3854865 | cell-based format |
| CHEMBL203599 |  |
IC50 | = | 1.2 | nM | 467.94 | CN1CCN(CCC#CC(=O)Nc2cc3c(Nc4ccc(F)c(Cl)c4)ncnc3cn2)CC1 | Homo sapiens | CHEMBL862514 | assay format |
| CHEMBL4647228 |  |
IC50 | = | 1.2 | nM | 509.03 | C=CC(=O)Nc1cc2c(Nc3ccc(F)c(Cl)c3)ccnc2cc1OCCC1CC12CCN(C)CC2 | Homo sapiens | CHEMBL4625051 | single protein format |
| CHEMBL3936761 |  |
IC50 | = | 1.58 | nM | 471.56 | C=CC(=O)N1CCC([C@@H]2CCNc3c(C(N)=O)c(-c4ccc(Oc5ccccc5)cc4)nn32)CC1 | Homo sapiens | CHEMBL5210352 | single protein format |
| CHEMBL5182567 |  |
IC50 | = | 1.6 | nM | 408.26 | C=CC(=O)Nc1ccc2ncnc(Nc3ccc4[nH]cc(Br)c4c3)c2c1 | Homo sapiens | CHEMBL5161061 | single protein format |
| CHEMBL202360 |  |
IC50 | = | 1.7 | nM | 367.21 | C#CC(=O)Nc1ccc2ncnc(Nc3cccc(Br)c3)c2c1 | Homo sapiens | CHEMBL862514 | assay format |
| CHEMBL205059 |  |
IC50 | = | 1.8 | nM | 452.92 | O=C(C#CCCN1CCCCC1)Nc1cc2c(Nc3ccc(F)c(Cl)c3)ncnc2cn1 | Homo sapiens | CHEMBL862514 | assay format |
| CHEMBL3890186 |  |
IC50 | = | 2.0 | nM | 577.69 | COCCOc1cc2ncnc(Nc3ccc4c(cnn4Cc4ccccc4)c3)c2cc1NC(=O)/C=C/CN1CCCC1 | Homo sapiens | CHEMBL3854865 | cell-based format |
| CHEMBL5208454 |  |
IC50 | = | 2.0 | nM | 444.72 | O=C(CCCl)Nc1ccc2ncnc(Nc3ccc4[nH]cc(Br)c4c3)c2c1 | Homo sapiens | CHEMBL5161061 | single protein format |
| CHEMBL3896779 |  |
IC50 | = | 2.0 | nM | 466.55 | O=C(/C=C/CN1CCCC1)Nc1cc2c(Nc3ccc(Oc4ccccc4)cc3)ncnc2cn1 | Homo sapiens | CHEMBL3854865 | cell-based format |
| CHEMBL4075917 |  |
IC50 | = | 2.4 | nM | 454.51 | Cc1n[nH]c2ccc(-c3cc(N[C@@H](CO)c4ccccc4)cnc3-c3ccc(F)cc3O)cc12 | Homo sapiens | CHEMBL4018635 | single protein format |
| CHEMBL203645 |  |
IC50 | = | 2.4 | nM | 383.81 | CCCC#CC(=O)Nc1cc2c(Nc3ccc(F)c(Cl)c3)ncnc2cn1 | Homo sapiens | CHEMBL862514 | assay format |
| CHEMBL3986103 |  |
IC50 | = | 3.0 | nM | 572.69 | CCOc1cc2ncnc(Nc3ccc(NS(=O)(=O)c4ccccc4)cc3)c2cc1NC(=O)/C=C/CN1CCCC1 | Homo sapiens | CHEMBL3854865 | cell-based format |