Q15139 | KPCD1_HUMAN | Serine/threonine-protein kinase D1 (PRKD1)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00069 | Pkinase - Protein kinase domain | 587~839 | |
| PF00130 | C1_1 - Phorbol esters/diacylglycerol binding domain (C1 domain) | 150~197 | |
| PF00130 | C1_1 - Phorbol esters/diacylglycerol binding domain (C1 domain) | 271~320 | |
| PF00169 | PH - PH domain | 423~497 | |
| PF25525 | Ubiquitin_PRKD1_N - Serine/threonine-protein kinase D1-like, ubiquitin-like domain | 49~135 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL1215711 |  |
IC50 | = | 0.4 | nM | 390.49 | c1cc2c(N3CCNCC3)nc(-c3ccnc(NC4CCOCC4)c3)cc2cn1 | Homo sapiens | CHEMBL1219826 | single protein format |
| CHEMBL1214998 |  |
IC50 | = | 0.6 | nM | 388.52 | c1cc2c(N3CCNCC3)nc(-c3ccnc(NC4CCCCC4)c3)cc2cn1 | Homo sapiens | CHEMBL1219826 | single protein format |
| CHEMBL1215710 |  |
IC50 | = | 1.0 | nM | 416.57 | NCC1CCN(c2nc(-c3ccnc(NC4CCCCC4)c3)cc3cnccc23)CC1 | Homo sapiens | CHEMBL1219826 | single protein format |
| CHEMBL1215363 |  |
IC50 | = | 1.0 | nM | 392.51 | O=C1NCc2c1cc(N1CCNCC1)nc2-c1ccnc(NC2CCCCC2)c1 | Homo sapiens | CHEMBL1219870 | single protein format |
| CHEMBL1215001 |  |
IC50 | = | 1.0 | nM | 382.47 | NC(=O)c1cc(-c2ccnc(NC3CCOCC3)c2)nc(N2CCNCC2)c1 | Homo sapiens | CHEMBL1219870 | single protein format |
| CHEMBL1214860 |  |
IC50 | = | 1.0 | nM | 529.69 | O=C(NCCN1CCCC1)C1CCN(c2nc(-c3ccnc(NC4CCOCC4)c3)cc3cnccc23)CC1 | Homo sapiens | CHEMBL1219826 | single protein format |
| CHEMBL1214712 |  |
IC50 | = | 1.0 | nM | 527.72 | O=C(NCCN1CCCC1)C1CCN(c2nc(-c3ccnc(NC4CCCCC4)c3)cc3cnccc23)CC1 | Homo sapiens | CHEMBL1219826 | single protein format |
| CHEMBL1214711 |  |
IC50 | = | 1.0 | nM | 513.69 | O=C(NC1CCNCC1)C1CCN(c2nc(-c3ccnc(NC4CCCCC4)c3)cc3cnccc23)CC1 | Homo sapiens | CHEMBL1219826 | single protein format |
| CHEMBL1215002 |  |
IC50 | = | 1.0 | nM | 340.43 | CC(C)Nc1cc(-c2cc(C(N)=O)cc(N3CCNCC3)n2)ccn1 | Homo sapiens | CHEMBL1219870 | single protein format |
| CHEMBL1215074 |  |
IC50 | = | 1.0 | nM | 378.44 | Cn1ccc(Nc2cc(-c3cc(C(N)=O)cc(N4CCNCC4)n3)ccn2)n1 | Homo sapiens | CHEMBL1219870 | single protein format |
| CHEMBL1215075 |  |
IC50 | = | 1.0 | nM | 408.89 | NC(=O)c1cc(-c2ccnc(Nc3ccccc3Cl)c2)nc(N2CCNCC2)c1 | Homo sapiens | CHEMBL1219870 | single protein format |
| CHEMBL1215712 |  |
IC50 | = | 1.0 | nM | 446.6 | CC(C)CN1CCN(c2nc(-c3ccnc(NC4CCOCC4)c3)cc3cnccc23)CC1 | Homo sapiens | CHEMBL1219826 | single protein format |
| CHEMBL1214999 |  |
IC50 | = | 1.0 | nM | 380.5 | NC(=O)c1cc(-c2ccnc(NC3CCCCC3)c2)nc(N2CCNCC2)c1 | Homo sapiens | CHEMBL1219870 | single protein format |
| CHEMBL1215000 |  |
IC50 | = | 1.0 | nM | 374.45 | NC(=O)c1cc(-c2ccnc(Nc3ccccc3)c2)nc(N2CCNCC2)c1 | Homo sapiens | CHEMBL1219870 | single protein format |
| CHEMBL5440043 |  |
IC50 | = | 1.0 | nM | 366.47 | NC(=O)c1cc(-c2ccnc(N3CCCCC3)c2)nc(N2CCNCC2)c1 | Homo sapiens | CHEMBL5316849 | single protein format |
| CHEMBL5428541 |  |
IC50 | = | 1.0 | nM | 338.42 | CC[C@H](N)CNc1ccnc(-c2cc(-c3cnn(C)c3)ccc2O)n1 | Homo sapiens | CHEMBL5316849 | single protein format |
| CHEMBL1215153 |  |
IC50 | < | 1.0 | nM | 363.47 | CC(C)Nc1cc(-c2cc(-c3cn[nH]c3)cc(N3CCNCC3)n2)ccn1 | Homo sapiens | CHEMBL1219870 | single protein format |
| CHEMBL5419827 |  |
IC50 | = | 1.0 | nM | 454.57 | CCOc1ccc2cc(-c3cc(-c4cccc(C(=O)NCCN(C)C)c4)cnc3N)ccc2c1 | Homo sapiens | CHEMBL5316849 | single protein format |
| CHEMBL1215219 |  |
IC50 | < | 1.0 | nM | 405.51 | c1cc(-c2cc(-c3cn[nH]c3)cc(N3CCNCC3)n2)cc(NC2CCOCC2)n1 | Homo sapiens | CHEMBL1219870 | single protein format |
| CHEMBL1215151 |  |
IC50 | < | 1.0 | nM | 403.53 | c1cc(-c2cc(-c3cn[nH]c3)cc(N3CCNCC3)n2)cc(NC2CCCCC2)n1 | Homo sapiens | CHEMBL1219870 | single protein format |