Q15120 | PDK3_HUMAN | [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 3, mitochondrial (PDK3)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF02518 | HATPase_c - Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase | 238~359 | |
| PF10436 | BCDHK_Adom3 - Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase | 26~188 |
3D structures mapped by conservation among orthologs
[ Domain: "alpha-ketoacid dehydrogenase kinase-N" // BCDHK_Adom3 ]
[ Domain: "ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase" // HATPase_c ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL4519504 |  |
IC50 | = | 5.0 | nM | 506.3 | CN(C)C(=O)c1ccc(N(Cc2ccc(I)o2)C(=O)c2ccc(O)cc2O)cc1 | Homo sapiens | CHEMBL4403264 | single protein format |
| CHEMBL3727577 |  |
IC50 | = | 40.0 | nM | 552.97 | Cc1cnc(Cl)nc1-c1ccc(N(Cc2ccc(CNC(=O)C(F)F)cc2)C(=O)c2ccc(O)cc2O)cc1 | Homo sapiens | CHEMBL4008878 | single protein format |
| CHEMBL4575355 |  |
IC50 | = | 59.0 | nM | 459.3 | CN(C)C(=O)c1ccc(N(Cc2ccc(Br)o2)C(=O)c2ccc(O)cc2O)cc1 | Homo sapiens | CHEMBL4403264 | single protein format |
| CHEMBL4461160 |  |
IC50 | = | 64.0 | nM | 476.35 | CN(C)C(=O)c1ccc(N(Cc2ncc(Br)s2)C(=O)c2ccc(O)cc2O)cc1 | Homo sapiens | CHEMBL4403264 | single protein format |
| CHEMBL4570690 |  |
IC50 | = | 67.0 | nM | 380.4 | CN(C)C(=O)c1ccc(N(Cc2ccco2)C(=O)c2ccc(O)cc2O)cc1 | Homo sapiens | CHEMBL4403264 | single protein format |
| CHEMBL4591977 |  |
IC50 | = | 80.0 | nM | 475.36 | CN(C)C(=O)c1ccc(N(Cc2cc(Br)cs2)C(=O)c2ccc(O)cc2O)cc1 | Homo sapiens | CHEMBL4403264 | single protein format |
| CHEMBL4551410 |  |
IC50 | = | 90.0 | nM | 475.36 | CN(C)C(=O)c1ccc(N(Cc2ccc(Br)s2)C(=O)c2ccc(O)cc2O)cc1 | Homo sapiens | CHEMBL4403264 | single protein format |
| CHEMBL4452536 |  |
IC50 | = | 90.0 | nM | 476.35 | CN(C)C(=O)c1ccc(N(Cc2cnc(Br)s2)C(=O)c2ccc(O)cc2O)cc1 | Homo sapiens | CHEMBL4403264 | single protein format |
| CHEMBL4513465 |  |
IC50 | = | 98.0 | nM | 421.48 | CN(C)C(=O)c1ccc(N(Cc2ccc(C#N)s2)C(=O)c2ccc(O)cc2O)cc1 | Homo sapiens | CHEMBL4403264 | single protein format |
| CHEMBL4540811 |  |
IC50 | = | 136.0 | nM | 406.44 | CN(C)C(=O)c1ccc(N(Cc2ccc(O)cc2)C(=O)c2ccc(O)cc2O)cc1 | Homo sapiens | CHEMBL4403264 | single protein format |
| CHEMBL4434941 |  |
IC50 | = | 142.0 | nM | 392.43 | CN(C)C(=O)c1ccc(N(Cc2ccc(F)cc2)C(=O)c2ccc(O)cc2)cc1 | Homo sapiens | CHEMBL4403264 | single protein format |
| CHEMBL4587341 |  |
IC50 | = | 181.0 | nM | 414.85 | CN(C)C(=O)c1ccc(N(Cc2ccc(Cl)o2)C(=O)c2ccc(O)cc2O)cc1 | Homo sapiens | CHEMBL4403264 | single protein format |
| CHEMBL4558944 |  |
IC50 | = | 186.0 | nM | 408.43 | CN(C)C(=O)c1ccc(N(Cc2ccc(F)cc2)C(=O)c2ccc(O)cc2O)cc1 | Homo sapiens | CHEMBL4403264 | single protein format |
| CHEMBL4558837 |  |
IC50 | = | 255.0 | nM | 394.43 | Cc1ccc(CN(C(=O)c2ccc(O)cc2O)c2ccc(C(=O)N(C)C)cc2)o1 | Homo sapiens | CHEMBL4403264 | single protein format |
| CHEMBL4561336 |  |
IC50 | = | 461.0 | nM | 415.45 | CN(C)C(=O)c1ccc(N(Cc2ccc(C#N)cc2)C(=O)c2ccc(O)cc2O)cc1 | Homo sapiens | CHEMBL4403264 | single protein format |
| CHEMBL4579724 |  |
IC50 | = | 858.0 | nM | 396.49 | CN(C)C(=O)c1ccc(N(CC2CCCCC2)C(=O)c2ccc(O)cc2O)cc1 | Homo sapiens | CHEMBL4403264 | single protein format |
| CHEMBL4061698 |  |
Ki | = | 550.0 | nM | 273.29 | COc1ccc(N(C)C(=O)c2ccc(O)cc2O)cc1 | Homo sapiens | CHEMBL4008868 | single protein format |