Q15119 | PDK2_HUMAN | [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial (PDK2)
Pfam Domain Table
Accession | Domain | Range | Color |
---|---|---|---|
PF02518 | HATPase_c - Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase | 242~361 | |
PF10436 | BCDHK_Adom3 - Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase | 30~192 |
3D structures mapped by conservation among orthologs
[ Domain: "alpha-ketoacid dehydrogenase kinase-N" // BCDHK_Adom3 ]
[ Domain: "ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase" // HATPase_c ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
---|---|---|---|---|---|---|---|---|---|---|
CHEMBL5079107 | IC50 | = | 4.2 | nM | 493.61 | Cc1nc2[nH]c3c(C4CC4)cccc3c2cc1-c1nnc(C(NC(=O)CCc2ccccc2)C(C)C)o1 | Homo sapiens | CHEMBL5057865 | single protein format | |
CHEMBL3673097 | IC50 | = | 4.2 | nM | 517.55 | CC(C)(O)CCCOc1cc(-c2cnn(C(C)(C)C(N)=O)c2)c2c(c1)[C@@](O)(C(F)(F)F)c1ccccc1-2 | Homo sapiens | CHEMBL3705739 | cell-based format | |
CHEMBL5079949 | IC50 | = | 4.5 | nM | 455.56 | Cc1nc(N2C[C@@](Cc3ccccc3)(C(N)=O)C[C@H]2CO)c2c(n1)[nH]c1c(C3CC3)cccc12 | Homo sapiens | CHEMBL5057865 | single protein format | |
CHEMBL3673096 | IC50 | = | 4.6 | nM | 503.52 | CC(C)(O)CCOc1cc(-c2cnn(C(C)(C)C(N)=O)c2)c2c(c1)[C@@](O)(C(F)(F)F)c1ccccc1-2 | Homo sapiens | CHEMBL3705739 | cell-based format | |
CHEMBL3673095 | IC50 | = | 5.1 | nM | 419.38 | CC(C)(C(N)=O)n1cc(-c2cc(F)cc3c2-c2ccccc2[C@]3(O)C(F)(F)F)cn1 | Homo sapiens | CHEMBL3705739 | cell-based format | |
CHEMBL5087040 | IC50 | = | 5.1 | nM | 431.5 | Cc1nc(N2C[C@@H](c3ccc(C(=O)O)[nH]3)C[C@H]2CO)c2c(n1)[nH]c1c(C3CC3)cccc12 | Homo sapiens | CHEMBL5057865 | single protein format | |
CHEMBL3673092 | IC50 | = | 5.1 | nM | 567.61 | NC(=O)Cn1cc(-c2cc(OCCC34CC5CC(CC(O)(C5)C3)C4)cc3c2-c2ccccc2[C@]3(O)C(F)(F)F)cn1 | Homo sapiens | CHEMBL3705739 | cell-based format | |
CHEMBL5072731 | IC50 | = | 5.5 | nM | 430.51 | Cc1nc(N2C[C@@H](c3ccc(C(N)=O)[nH]3)C[C@H]2CO)c2c(n1)[nH]c1c(C3CC3)cccc12 | Homo sapiens | CHEMBL5057865 | single protein format | |
CHEMBL5087238 | IC50 | = | 6.0 | nM | 493.61 | Cc1nc2[nH]c3c(C4CC4)cccc3c2cc1-c1nnc(C(CC(=O)NCc2ccccc2)C(C)C)o1 | Homo sapiens | CHEMBL5057865 | single protein format | |
CHEMBL3673094 | IC50 | = | 6.7 | nM | 448.44 | CC(C)(O)COc1cc(-c2cnn(CCO)c2)c2c(c1)[C@@](O)(C(F)(F)F)c1ccccc1-2 | Homo sapiens | CHEMBL3705739 | cell-based format | |
CHEMBL3673093 | IC50 | = | 7.4 | nM | 418.42 | Cn1cc(-c2cc(OCC(C)(C)O)cc3c2-c2ccccc2[C@]3(O)C(F)(F)F)cn1 | Homo sapiens | CHEMBL3705739 | cell-based format | |
CHEMBL4579004 | IC50 | = | 7.8 | nM | 383.37 | C[C@@H]1CN(C(=O)[C@](C)(O)C(F)(F)F)[C@@H](C)CN1C(=O)c1ccc(C#N)cc1 | Homo sapiens | CHEMBL4413248 | single protein format | |
CHEMBL4591977 | IC50 | = | 8.0 | nM | 475.36 | CN(C)C(=O)c1ccc(N(Cc2cc(Br)cs2)C(=O)c2ccc(O)cc2O)cc1 | Homo sapiens | CHEMBL4403261 | single protein format | |
CHEMBL5089800 | IC50 | = | 9.2 | nM | 429.52 | CC[C@@H]1C[C@H](c2ccc(C(=O)O)[nH]2)CN1c1nc(C)nc2[nH]c3c(C4CC4)cccc3c12 | Homo sapiens | CHEMBL5057865 | single protein format | |
CHEMBL4575355 | IC50 | = | 10.0 | nM | 459.3 | CN(C)C(=O)c1ccc(N(Cc2ccc(Br)o2)C(=O)c2ccc(O)cc2O)cc1 | Homo sapiens | CHEMBL4403261 | single protein format | |
CHEMBL3681809 | IC50 | = | 14.0 | nM | 448.44 | OCCCCOc1cc(-c2cnn(CCO)c2)c2c(c1)C(O)(C(F)(F)F)c1ccccc1-2 | Homo sapiens | CHEMBL3705869 | cell-based format | |
CHEMBL5092915 | IC50 | = | 14.6 | nM | 442.56 | Cc1nc(N2C[C@](CO)(Cc3ccccc3)C[C@H]2CO)c2c(n1)[nH]c1c(C3CC3)cccc12 | Homo sapiens | CHEMBL5057865 | single protein format | |
CHEMBL3681729 | IC50 | = | 15.0 | nM | 567.61 | NC(=O)Cn1cc(-c2cc(OCCC34CC5CC(CC(O)(C5)C3)C4)cc3c2-c2ccccc2C3(O)C(F)(F)F)cn1 | Homo sapiens | CHEMBL3705869 | cell-based format | |
CHEMBL3681730 | IC50 | = | 15.0 | nM | 554.61 | OCCn1cc(-c2cc(OCCC34CC5CC(CC(O)(C5)C3)C4)cc3c2-c2ccccc2C3(O)C(F)(F)F)cn1 | Homo sapiens | CHEMBL3705869 | cell-based format | |
CHEMBL3681843 | IC50 | = | 15.0 | nM | 444.45 | CC(C)=Cc1cc(-c2cnn(C(CO)CO)c2)c2c(c1)C(O)(C(F)(F)F)c1ccccc1-2 | Homo sapiens | CHEMBL3705869 | cell-based format |