Q15119 | PDK2_HUMAN | [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial (PDK2)

Pfam Domain Table

AccessionDomainRangeColor
PF02518HATPase_c - Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase242~361
PF10436BCDHK_Adom3 - Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase30~192

3D structures mapped by conservation among orthologs

[ Domain: "alpha-ketoacid dehydrogenase kinase-N" // BCDHK_Adom3 ]

 PyMOL session

[ Domain: "ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase" // HATPase_c ]

 PyMOL session


[ Alpha Fold Model ] (go)



Known binders annotated in ChEMBL

 IC50 CSV    Ki CSV
Only the first 20 rows are shown.
molecule_chembl_idstructureassay_typerelation valueunitmol_wtsmilesorganism assay_chembl_idbao_label
CHEMBL5079107 IC50 = 4.2 nM 493.61 Cc1nc2[nH]c3c(C4CC4)cccc3c2cc1-c1nnc(C(NC(=O)CCc2ccccc2)C(C)C)o1 Homo sapiens CHEMBL5057865 single protein format
CHEMBL3673097 IC50 = 4.2 nM 517.55 CC(C)(O)CCCOc1cc(-c2cnn(C(C)(C)C(N)=O)c2)c2c(c1)[C@@](O)(C(F)(F)F)c1ccccc1-2 Homo sapiens CHEMBL3705739 cell-based format
CHEMBL5079949 IC50 = 4.5 nM 455.56 Cc1nc(N2C[C@@](Cc3ccccc3)(C(N)=O)C[C@H]2CO)c2c(n1)[nH]c1c(C3CC3)cccc12 Homo sapiens CHEMBL5057865 single protein format
CHEMBL3673096 IC50 = 4.6 nM 503.52 CC(C)(O)CCOc1cc(-c2cnn(C(C)(C)C(N)=O)c2)c2c(c1)[C@@](O)(C(F)(F)F)c1ccccc1-2 Homo sapiens CHEMBL3705739 cell-based format
CHEMBL3673095 IC50 = 5.1 nM 419.38 CC(C)(C(N)=O)n1cc(-c2cc(F)cc3c2-c2ccccc2[C@]3(O)C(F)(F)F)cn1 Homo sapiens CHEMBL3705739 cell-based format
CHEMBL5087040 IC50 = 5.1 nM 431.5 Cc1nc(N2C[C@@H](c3ccc(C(=O)O)[nH]3)C[C@H]2CO)c2c(n1)[nH]c1c(C3CC3)cccc12 Homo sapiens CHEMBL5057865 single protein format
CHEMBL3673092 IC50 = 5.1 nM 567.61 NC(=O)Cn1cc(-c2cc(OCCC34CC5CC(CC(O)(C5)C3)C4)cc3c2-c2ccccc2[C@]3(O)C(F)(F)F)cn1 Homo sapiens CHEMBL3705739 cell-based format
CHEMBL5072731 IC50 = 5.5 nM 430.51 Cc1nc(N2C[C@@H](c3ccc(C(N)=O)[nH]3)C[C@H]2CO)c2c(n1)[nH]c1c(C3CC3)cccc12 Homo sapiens CHEMBL5057865 single protein format
CHEMBL5087238 IC50 = 6.0 nM 493.61 Cc1nc2[nH]c3c(C4CC4)cccc3c2cc1-c1nnc(C(CC(=O)NCc2ccccc2)C(C)C)o1 Homo sapiens CHEMBL5057865 single protein format
CHEMBL3673094 IC50 = 6.7 nM 448.44 CC(C)(O)COc1cc(-c2cnn(CCO)c2)c2c(c1)[C@@](O)(C(F)(F)F)c1ccccc1-2 Homo sapiens CHEMBL3705739 cell-based format
CHEMBL3673093 IC50 = 7.4 nM 418.42 Cn1cc(-c2cc(OCC(C)(C)O)cc3c2-c2ccccc2[C@]3(O)C(F)(F)F)cn1 Homo sapiens CHEMBL3705739 cell-based format
CHEMBL4579004 IC50 = 7.8 nM 383.37 C[C@@H]1CN(C(=O)[C@](C)(O)C(F)(F)F)[C@@H](C)CN1C(=O)c1ccc(C#N)cc1 Homo sapiens CHEMBL4413248 single protein format
CHEMBL4591977 IC50 = 8.0 nM 475.36 CN(C)C(=O)c1ccc(N(Cc2cc(Br)cs2)C(=O)c2ccc(O)cc2O)cc1 Homo sapiens CHEMBL4403261 single protein format
CHEMBL5089800 IC50 = 9.2 nM 429.52 CC[C@@H]1C[C@H](c2ccc(C(=O)O)[nH]2)CN1c1nc(C)nc2[nH]c3c(C4CC4)cccc3c12 Homo sapiens CHEMBL5057865 single protein format
CHEMBL4575355 IC50 = 10.0 nM 459.3 CN(C)C(=O)c1ccc(N(Cc2ccc(Br)o2)C(=O)c2ccc(O)cc2O)cc1 Homo sapiens CHEMBL4403261 single protein format
CHEMBL3681809 IC50 = 14.0 nM 448.44 OCCCCOc1cc(-c2cnn(CCO)c2)c2c(c1)C(O)(C(F)(F)F)c1ccccc1-2 Homo sapiens CHEMBL3705869 cell-based format
CHEMBL5092915 IC50 = 14.6 nM 442.56 Cc1nc(N2C[C@](CO)(Cc3ccccc3)C[C@H]2CO)c2c(n1)[nH]c1c(C3CC3)cccc12 Homo sapiens CHEMBL5057865 single protein format
CHEMBL3681729 IC50 = 15.0 nM 567.61 NC(=O)Cn1cc(-c2cc(OCCC34CC5CC(CC(O)(C5)C3)C4)cc3c2-c2ccccc2C3(O)C(F)(F)F)cn1 Homo sapiens CHEMBL3705869 cell-based format
CHEMBL3681730 IC50 = 15.0 nM 554.61 OCCn1cc(-c2cc(OCCC34CC5CC(CC(O)(C5)C3)C4)cc3c2-c2ccccc2C3(O)C(F)(F)F)cn1 Homo sapiens CHEMBL3705869 cell-based format
CHEMBL3681843 IC50 = 15.0 nM 444.45 CC(C)=Cc1cc(-c2cnn(C(CO)CO)c2)c2c(c1)C(O)(C(F)(F)F)c1ccccc1-2 Homo sapiens CHEMBL3705869 cell-based format