Q15109 | RAGE_HUMAN | Advanced glycosylation end product-specific receptor (AGER)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF08205 | C2-set_2 - CD80-like C2-set immunoglobulin domain | 124~218 | |
| PF13927 | Ig_3 - Immunoglobulin domain | 240~304 |
3D structures mapped by conservation among orthologs
[ Domain: "Immunoglobulin/Fibronectin type III/E set domains/PapD-like" // I-set_4 ]
[ Domain: "Immunoglobulin/Fibronectin type III/E set domains/PapD-like" // I-set_15 ]
[ Domain: "Immunoglobulin/Fibronectin type III/E set domains/PapD-like" // UNK_F_TYPE ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL2205559 |  |
IC50 | = | 660.0 | nM | 561.19 | CCCCc1sc(-c2ccc(OCC3CCCN(CC)C3)cc2)nc1-c1ccc(Oc2ccc(Cl)cc2)cc1 | Homo sapiens | CHEMBL2210069 | single protein format |
| CHEMBL2205572 |  |
IC50 | = | 910.0 | nM | 533.14 | CCCCc1sc(-c2ccc(OCCN3CCCC3)cc2)nc1-c1ccc(Oc2ccc(Cl)cc2)cc1 | Homo sapiens | CHEMBL2210069 | single protein format |
| CHEMBL4075936 |  |
Ki | = | 25.0 | nM | 327.86 | O=C(c1ccc(Cl)cc1)N(Cc1ccccc1)C1CCCCC1 | Homo sapiens | CHEMBL4030328 | cell-based format |