Q15059 | BRD3_HUMAN | Bromodomain-containing protein 3 (BRD3)
Pfam Domain Table
Accession | Domain | Range | Color |
---|---|---|---|
PF00439 | Bromodomain - Bromodomain | 46~127 | |
PF00439 | Bromodomain - Bromodomain | 315~402 | |
PF17035 | BET - Bromodomain extra-terminal - transcription regulation | 571~635 |
3D structures mapped by conservation among orthologs
[ Domain: "Bromodomain-containing protein 4 ET domain" // BET ]
[ Domain: "Bromodomain" // Bromodomain ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
---|---|---|---|---|---|---|---|---|---|---|
CHEMBL4297454 | IC50 | = | 0.88 | nM | 491.56 | CCNC(=O)c1cc2c(-c3cc(C(C)(C)O)ccc3Oc3c(C)cc(F)cc3C)cn(C)c(=O)c2[nH]1 | Homo sapiens | CHEMBL5162525 | single protein format | |
CHEMBL4297458 | IC50 | = | 1.1 | nM | 495.63 | Cc1nnn(C)c1-c1cnc2c3ccc(C(C)(C)O)cc3n([C@H](c3ccccc3)C3CCOCC3)c2c1 | Homo sapiens | CHEMBL5054312 | single protein format | |
CHEMBL4859923 | IC50 | = | 1.6 | nM | 516.64 | [2H]C([2H])([2H])c1nnn(C)c1-c1cnc2c3cc(F)c(C(C)(C)O)cc3n([C@H](c3ccccc3)C3CCOCC3)c2c1 | Homo sapiens | CHEMBL5125727 | single protein format | |
CHEMBL5087175 | IC50 | = | 1.9 | nM | 495.62 | Cc1noc(C)c1-c1cnc2c3ccc(C(C)(C)O)cc3n([C@H](c3ccccc3)C3CCOCC3)c2c1 | Homo sapiens | CHEMBL5054312 | single protein format | |
CHEMBL4228445 | IC50 | = | 1.9 | nM | 500.56 | CCn1nc(C2CC2)cc1Nc1nc(C(=O)NC)nc2[nH]c3cc(-c4c(C)noc4C)c(OC)cc3c12 | Homo sapiens | CHEMBL4219279 | assay format | |
CHEMBL4780530 | IC50 | = | 3.0 | nM | 416.92 | Cc1nnc2n1-c1ccc(-c3ccc(N)nc3)cc1N(c1ccc(Cl)cc1)C[C@H]2C | Homo sapiens | CHEMBL4716997 | single protein format | |
CHEMBL3895413 | IC50 | = | 5.3 | nM | 402.5 | Cc1noc(C)c1-c1ccc2c(c1)C(c1ccccc1)(N1CCC[C@H](N)C1)C(=O)N2 | Homo sapiens | CHEMBL3888743 | single protein format | |
CHEMBL5206088 | IC50 | = | 5.31 | nM | 555.65 | Cc1cc(F)cc(C)c1Oc1ccc(C(C)(C)O)cc1-c1cn(C)c(=O)c2cc(-c3cnc(C4CCCC4)[nH]3)oc12 | Homo sapiens | CHEMBL5162525 | single protein format | |
CHEMBL4577491 | IC50 | = | 7.0 | nM | 531.08 | Cc1sc2c(c1C)C(c1ccc(Cl)cc1)=N[C@@H](CC(=O)NCCOCCOCCN)c1nnc(C)n1-2 | Homo sapiens | CHEMBL4312046 | single protein format | |
CHEMBL3605565 | IC50 | = | 7.11 | nM | 544.64 | CC(=O)OC[C@]12CC[C@H]3[C@@H](C[C@H]4O[C@]45CC=CC(=O)[C@]35C)[C@]1(O)CC[C@@]2(O)[C@@](C)(O)[C@H]1CC(C)=C(C)C(=O)O1 | Homo sapiens | CHEMBL5317640 | assay format | |
CHEMBL4168815 | IC50 | = | 9.0 | nM | 402.89 | Cc1nnn2c1-c1ccc(-c3ccc(N)nc3)cc1N(c1ccc(Cl)cc1)CC2 | Homo sapiens | CHEMBL4144033 | assay format | |
CHEMBL3903717 | IC50 | = | 9.9 | nM | 403.48 | Cc1noc(C)c1-c1ccc2c(c1)C(c1ccccc1)(N1CCC[C@H](O)C1)C(=O)N2 | Homo sapiens | CHEMBL3888743 | single protein format | |
CHEMBL4173305 | IC50 | = | 10.0 | nM | 401.9 | Cc1ccc(-c2ccc3c(c2)N(c2ccc(Cl)cc2)CCn2nnc(C)c2-3)cn1 | Homo sapiens | CHEMBL4144033 | assay format | |
CHEMBL4177080 | IC50 | = | 10.0 | nM | 376.85 | Cc1nnn2c1-c1ccc(-c3cc[nH]n3)cc1N(c1ccc(Cl)cc1)CC2 | Homo sapiens | CHEMBL4144033 | assay format | |
CHEMBL4170756 | IC50 | = | 11.0 | nM | 324.82 | Cc1nnn2c1-c1ccccc1N(c1ccc(Cl)cc1)C[C@H]2C | Homo sapiens | CHEMBL4144033 | assay format | |
CHEMBL3650967 | IC50 | < | 11.0 | nM | 433.9 | Cc1nn(C2CC2)c2c1[C@@H](c1ccc(Cl)cc1)N(c1cc(C)c3nnc(C)n3n1)C2=O | Homo sapiens | CHEMBL3707497 | single protein format | |
CHEMBL4850926 | IC50 | = | 11.0 | nM | 535.03 | Cc1sc2c(c1C)C(c1ccc(Cl)cc1)=N[C@@H](CC(=O)Nc1ccc(C(=O)NO)cc1)c1nnc(C)n1-2 | Homo sapiens | CHEMBL5096325 | single protein format | |
CHEMBL4162832 | IC50 | = | 12.0 | nM | 457.97 | Cc1nnn2c1-c1ccc(C(=O)N[C@@H](C)c3ccccc3)cc1N(c1ccc(Cl)cc1)CC2 | Homo sapiens | CHEMBL4144033 | assay format | |
CHEMBL5204783 | IC50 | = | 12.81 | nM | 569.68 | Cc1cc(F)cc(C)c1Oc1ccc(C(C)(C)O)cc1-c1cn(C)c(=O)c2cc(-c3cnc(C4CCCCC4)[nH]3)oc12 | Homo sapiens | CHEMBL5162525 | single protein format | |
CHEMBL3654322 | IC50 | = | 13.0 | nM | 432.92 | Cc1cc(N2C(=O)c3c(c(C4CC4)nn3C)[C@H]2c2ccc(Cl)cc2)cn2c(C)nnc12 | Homo sapiens | CHEMBL3707497 | single protein format |