Q15059 | BRD3_HUMAN | Bromodomain-containing protein 3 (BRD3)

Pfam Domain Table

AccessionDomainRangeColor
PF00439Bromodomain - Bromodomain46~127
PF00439Bromodomain - Bromodomain315~402
PF17035BET - Bromodomain extra-terminal - transcription regulation571~635

3D structures mapped by conservation among orthologs

[ Domain: "Bromodomain-containing protein 4 ET domain" // BET ]

 PyMOL session

[ Domain: "Bromodomain" // Bromodomain ]

 PyMOL session


[ Alpha Fold Model ] (go)



Known binders annotated in ChEMBL

 IC50 CSV    Ki CSV
Only the first 20 rows are shown.
molecule_chembl_idstructureassay_typerelation valueunitmol_wtsmilesorganism assay_chembl_idbao_label
CHEMBL4297454 IC50 = 0.88 nM 491.56 CCNC(=O)c1cc2c(-c3cc(C(C)(C)O)ccc3Oc3c(C)cc(F)cc3C)cn(C)c(=O)c2[nH]1 Homo sapiens CHEMBL5162525 single protein format
CHEMBL4297458 IC50 = 1.1 nM 495.63 Cc1nnn(C)c1-c1cnc2c3ccc(C(C)(C)O)cc3n([C@H](c3ccccc3)C3CCOCC3)c2c1 Homo sapiens CHEMBL5054312 single protein format
CHEMBL4859923 IC50 = 1.6 nM 516.64 [2H]C([2H])([2H])c1nnn(C)c1-c1cnc2c3cc(F)c(C(C)(C)O)cc3n([C@H](c3ccccc3)C3CCOCC3)c2c1 Homo sapiens CHEMBL5125727 single protein format
CHEMBL5087175 IC50 = 1.9 nM 495.62 Cc1noc(C)c1-c1cnc2c3ccc(C(C)(C)O)cc3n([C@H](c3ccccc3)C3CCOCC3)c2c1 Homo sapiens CHEMBL5054312 single protein format
CHEMBL4228445 IC50 = 1.9 nM 500.56 CCn1nc(C2CC2)cc1Nc1nc(C(=O)NC)nc2[nH]c3cc(-c4c(C)noc4C)c(OC)cc3c12 Homo sapiens CHEMBL4219279 assay format
CHEMBL4780530 IC50 = 3.0 nM 416.92 Cc1nnc2n1-c1ccc(-c3ccc(N)nc3)cc1N(c1ccc(Cl)cc1)C[C@H]2C Homo sapiens CHEMBL4716997 single protein format
CHEMBL3895413 IC50 = 5.3 nM 402.5 Cc1noc(C)c1-c1ccc2c(c1)C(c1ccccc1)(N1CCC[C@H](N)C1)C(=O)N2 Homo sapiens CHEMBL3888743 single protein format
CHEMBL5206088 IC50 = 5.31 nM 555.65 Cc1cc(F)cc(C)c1Oc1ccc(C(C)(C)O)cc1-c1cn(C)c(=O)c2cc(-c3cnc(C4CCCC4)[nH]3)oc12 Homo sapiens CHEMBL5162525 single protein format
CHEMBL4577491 IC50 = 7.0 nM 531.08 Cc1sc2c(c1C)C(c1ccc(Cl)cc1)=N[C@@H](CC(=O)NCCOCCOCCN)c1nnc(C)n1-2 Homo sapiens CHEMBL4312046 single protein format
CHEMBL3605565 IC50 = 7.11 nM 544.64 CC(=O)OC[C@]12CC[C@H]3[C@@H](C[C@H]4O[C@]45CC=CC(=O)[C@]35C)[C@]1(O)CC[C@@]2(O)[C@@](C)(O)[C@H]1CC(C)=C(C)C(=O)O1 Homo sapiens CHEMBL5317640 assay format
CHEMBL4168815 IC50 = 9.0 nM 402.89 Cc1nnn2c1-c1ccc(-c3ccc(N)nc3)cc1N(c1ccc(Cl)cc1)CC2 Homo sapiens CHEMBL4144033 assay format
CHEMBL3903717 IC50 = 9.9 nM 403.48 Cc1noc(C)c1-c1ccc2c(c1)C(c1ccccc1)(N1CCC[C@H](O)C1)C(=O)N2 Homo sapiens CHEMBL3888743 single protein format
CHEMBL4173305 IC50 = 10.0 nM 401.9 Cc1ccc(-c2ccc3c(c2)N(c2ccc(Cl)cc2)CCn2nnc(C)c2-3)cn1 Homo sapiens CHEMBL4144033 assay format
CHEMBL4177080 IC50 = 10.0 nM 376.85 Cc1nnn2c1-c1ccc(-c3cc[nH]n3)cc1N(c1ccc(Cl)cc1)CC2 Homo sapiens CHEMBL4144033 assay format
CHEMBL4170756 IC50 = 11.0 nM 324.82 Cc1nnn2c1-c1ccccc1N(c1ccc(Cl)cc1)C[C@H]2C Homo sapiens CHEMBL4144033 assay format
CHEMBL3650967 IC50 < 11.0 nM 433.9 Cc1nn(C2CC2)c2c1[C@@H](c1ccc(Cl)cc1)N(c1cc(C)c3nnc(C)n3n1)C2=O Homo sapiens CHEMBL3707497 single protein format
CHEMBL4850926 IC50 = 11.0 nM 535.03 Cc1sc2c(c1C)C(c1ccc(Cl)cc1)=N[C@@H](CC(=O)Nc1ccc(C(=O)NO)cc1)c1nnc(C)n1-2 Homo sapiens CHEMBL5096325 single protein format
CHEMBL4162832 IC50 = 12.0 nM 457.97 Cc1nnn2c1-c1ccc(C(=O)N[C@@H](C)c3ccccc3)cc1N(c1ccc(Cl)cc1)CC2 Homo sapiens CHEMBL4144033 assay format
CHEMBL5204783 IC50 = 12.81 nM 569.68 Cc1cc(F)cc(C)c1Oc1ccc(C(C)(C)O)cc1-c1cn(C)c(=O)c2cc(-c3cnc(C4CCCCC4)[nH]3)oc12 Homo sapiens CHEMBL5162525 single protein format
CHEMBL3654322 IC50 = 13.0 nM 432.92 Cc1cc(N2C(=O)c3c(c(C4CC4)nn3C)[C@H]2c2ccc(Cl)cc2)cn2c(C)nnc12 Homo sapiens CHEMBL3707497 single protein format