Q15046 | SYK_HUMAN | Lysine--tRNA ligase (KARS1)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00152 | tRNA-synt_2 - tRNA synthetases class II (D, K and N) | 222~573 | |
| PF01336 | tRNA_anti-codon - OB-fold nucleic acid binding domain | 127~206 |
3D structures mapped by conservation among orthologs
[ Domain: "Nucleic acid-binding proteins" // tRNA_anti-codon ]
[ Domain: "Class II aaRS and biotin synthetases" // tRNA-synt_2 ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL2069346 |  |
IC50 | = | 0.6 | nM | 399.42 | FC(F)(F)c1ccnc(Nc2cccc(-c3cccc(N4CCNCC4)c3)n2)c1 | Homo sapiens | CHEMBL2072026 | single protein format |
| CHEMBL2069345 |  |
IC50 | = | 1.8 | nM | 400.41 | FC(F)(F)c1ccnc(Nc2cccc(-c3ccnc(N4CCNCC4)c3)n2)c1 | Homo sapiens | CHEMBL2072026 | single protein format |
| CHEMBL2069349 |  |
IC50 | = | 4.0 | nM | 348.41 | Nc1cc(Nc2cnccn2)nc(-c2ccnc(N3CCNCC3)c2)c1 | Homo sapiens | CHEMBL2072026 | single protein format |
| CHEMBL2069350 |  |
IC50 | = | 4.0 | nM | 362.44 | CNc1cc(Nc2cnccn2)nc(-c2ccnc(N3CCNCC3)c2)c1 | Homo sapiens | CHEMBL2072026 | single protein format |
| CHEMBL2069352 |  |
IC50 | = | 4.0 | nM | 459.56 | O=C(Nc1cc(Nc2cnccn2)nc(-c2ccnc(N3CCNCC3)c2)c1)C1CCNCC1 | Homo sapiens | CHEMBL2072026 | single protein format |
| CHEMBL475575 |  |
IC50 | = | 4.0 | nM | 426.48 | COc1cc(Nc2nc(N[C@H]3CCCC[C@H]3N)n3ncnc3c2C(N)=O)cc(OC)c1 | Homo sapiens | CHEMBL981176 | single protein format |
| CHEMBL2069358 |  |
IC50 | = | 4.0 | nM | 467.54 | O=C(Cc1cccnc1)Nc1cc(Nc2cnccn2)nc(-c2ccnc(N3CCNCC3)c2)c1 | Homo sapiens | CHEMBL2072026 | single protein format |
| CHEMBL2069353 |  |
IC50 | = | 5.0 | nM | 501.6 | CC(=O)N1CCC(C(=O)Nc2cc(Nc3cnccn3)nc(-c3ccnc(N4CCNCC4)c3)c2)CC1 | Homo sapiens | CHEMBL2072026 | single protein format |
| CHEMBL2069355 |  |
IC50 | = | 6.0 | nM | 453.51 | O=C(Nc1cc(Nc2cnccn2)nc(-c2ccnc(N3CCNCC3)c2)c1)c1cccnc1 | Homo sapiens | CHEMBL2072026 | single protein format |
| CHEMBL2069357 |  |
IC50 | = | 7.0 | nM | 470.54 | Cc1cc(C(=O)Nc2cc(Nc3cnccn3)nc(-c3ccnc(N4CCNCC4)c3)c2)n(C)n1 | Homo sapiens | CHEMBL2072026 | single protein format |
| CHEMBL4286991 |  |
IC50 | = | 7.2 | nM | 316.44 | CC(C)c1ccc2c(c1)CC[C@H]1[C@@](CO)(C(=O)O)CCC[C@]21C | Homo sapiens | CHEMBL4256130 | single protein format |
| CHEMBL2069351 |  |
IC50 | = | 8.0 | nM | 454.54 | Oc1ccc(CNc2cc(Nc3cnccn3)nc(-c3ccnc(N4CCNCC4)c3)c2)cc1 | Homo sapiens | CHEMBL2072026 | single protein format |
| CHEMBL2069359 |  |
IC50 | = | 8.0 | nM | 496.53 | O=C(O)c1ccc(C(=O)Nc2cc(Nc3cnccn3)nc(-c3ccnc(N4CCNCC4)c3)c2)cc1 | Homo sapiens | CHEMBL2072026 | single protein format |
| CHEMBL474582 |  |
IC50 | = | 9.0 | nM | 372.39 | COc1cc(Nc2nc(NCCN)n3cnnc3c2C(N)=O)cc(OC)c1 | Homo sapiens | CHEMBL981176 | single protein format |
| CHEMBL2069356 |  |
IC50 | = | 9.0 | nM | 454.5 | O=C(Nc1cc(Nc2cnccn2)nc(-c2ccnc(N3CCNCC3)c2)c1)c1cncnc1 | Homo sapiens | CHEMBL2072026 | single protein format |
| CHEMBL475609 |  |
IC50 | = | 9.0 | nM | 426.48 | COc1cc(Nc2nc(N[C@H]3CCCC[C@H]3N)n3cnnc3c2C(N)=O)cc(OC)c1 | Homo sapiens | CHEMBL981176 | single protein format |
| CHEMBL388978 |  |
IC50 | = | 9.0 | nM | 466.54 | CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 | Homo sapiens | CHEMBL981176 | single protein format |
| CHEMBL2069360 |  |
IC50 | = | 10.0 | nM | 497.52 | O=C(Nc1cc(Nc2cnccn2)nc(-c2ccnc(N3CCNCC3)c2)c1)c1ccc(C(=O)O)nc1 | Homo sapiens | CHEMBL2072026 | single protein format |
| CHEMBL4293812 |  |
IC50 | = | 10.7 | nM | 356.46 | C=C(C)c1ccc2c(c1)CC[C@H]1[C@](CC(=O)OC)(C(=O)O)CCC[C@]21C | Homo sapiens | CHEMBL4256130 | single protein format |
| CHEMBL2069341 |  |
IC50 | = | 14.0 | nM | 346.44 | Cc1ccnc(Nc2cccc(-c3ccnc(N4CCNCC4)c3)n2)c1 | Homo sapiens | CHEMBL2072026 | single protein format |