Q14994 | NR1I3_HUMAN | Nuclear receptor subfamily 1 group I member 3 (NR1I3)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00104 | Hormone_recep - Ligand-binding domain of nuclear hormone receptor | 159~329 | |
| PF00105 | zf-C4 - Double treble clef zinc finger, C4 type | 10~78 |
3D structures mapped by conservation among orthologs
[ Domain: "Nuclear receptor ligand-binding domain" // Hormone_recep ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL3763793 |  |
IC50 | = | 11.7 | nM | 443.55 | O=C(Nc1ccc2c(c1)N(C(=O)Cn1cccc1)c1ccccc1CC2)OC1CCCCC1 | Homo sapiens | CHEMBL3767622 | single protein format |
| CHEMBL3763399 |  |
IC50 | = | 13.9 | nM | 429.52 | O=C(Nc1ccc2c(c1)N(C(=O)Cn1cccc1)c1ccccc1CC2)OC1CCCC1 | Homo sapiens | CHEMBL3767622 | single protein format |
| CHEMBL3763536 |  |
IC50 | = | 19.5 | nM | 422.53 | CC(C)OC(=O)Nc1ccc2c(c1)N(C(=O)COC1CCCC1)c1ccccc1CC2 | Homo sapiens | CHEMBL3767622 | single protein format |
| CHEMBL3763664 |  |
IC50 | = | 20.1 | nM | 415.49 | O=C(Nc1ccc2c(c1)N(C(=O)Cn1cccc1)c1ccccc1CC2)OC1CCC1 | Homo sapiens | CHEMBL3767622 | single protein format |
| CHEMBL3764750 |  |
IC50 | = | 20.9 | nM | 403.48 | CC(C)OC(=O)Nc1ccc2c(c1)N(C(=O)Cn1cccc1)c1ccccc1CC2 | Homo sapiens | CHEMBL3767622 | single protein format |
| CHEMBL3765064 |  |
IC50 | = | 21.2 | nM | 424.54 | CC(C)OC(=O)Nc1ccc2c(c1)N(C(=O)COCC(C)(C)C)c1ccccc1CC2 | Homo sapiens | CHEMBL3767622 | single protein format |
| CHEMBL3763725 |  |
IC50 | = | 22.1 | nM | 401.47 | O=C(Nc1ccc2c(c1)N(C(=O)Cn1cccc1)c1ccccc1CC2)OC1CC1 | Homo sapiens | CHEMBL3767622 | single protein format |
| CHEMBL3764168 |  |
IC50 | = | 24.1 | nM | 436.55 | CC(C)OC(=O)Nc1ccc2c(c1)N(C(=O)COC1CCCCC1)c1ccccc1CC2 | Homo sapiens | CHEMBL3767622 | single protein format |
| CHEMBL3764583 |  |
IC50 | = | 31.9 | nM | 417.51 | CC(C)(C)OC(=O)Nc1ccc2c(c1)N(C(=O)Cn1cccc1)c1ccccc1CC2 | Homo sapiens | CHEMBL3767622 | single protein format |
| CHEMBL3765692 |  |
IC50 | = | 35.3 | nM | 410.51 | CCC(C)OCC(=O)N1c2ccccc2CCc2ccc(NC(=O)OC(C)C)cc21 | Homo sapiens | CHEMBL3767622 | single protein format |
| CHEMBL3763695 |  |
IC50 | = | 37.0 | nM | 389.46 | CCOC(=O)Nc1ccc2c(c1)N(C(=O)Cn1cccc1)c1ccccc1CC2 | Homo sapiens | CHEMBL3767622 | single protein format |
| CHEMBL3764324 |  |
IC50 | = | 37.6 | nM | 408.5 | CC(C)OC(=O)Nc1ccc2c(c1)N(C(=O)COC1CCC1)c1ccccc1CC2 | Homo sapiens | CHEMBL3767622 | single protein format |
| CHEMBL3763758 |  |
IC50 | = | 60.1 | nM | 396.49 | CC(C)OCC(=O)N1c2ccccc2CCc2ccc(NC(=O)OC(C)C)cc21 | Homo sapiens | CHEMBL3767622 | single protein format |
| CHEMBL3765243 |  |
IC50 | = | 70.8 | nM | 396.49 | CCOC(=O)Nc1ccc2c(c1)N(C(=O)COC(C)(C)C)c1ccccc1CC2 | Homo sapiens | CHEMBL3767622 | single protein format |
| CHEMBL3763979 |  |
IC50 | = | 81.5 | nM | 394.47 | CC(C)OC(=O)Nc1ccc2c(c1)N(C(=O)COC1CC1)c1ccccc1CC2 | Homo sapiens | CHEMBL3767622 | single protein format |
| CHEMBL3763569 |  |
IC50 | = | 116.0 | nM | 410.51 | CC(C)OCC(=O)N1c2ccccc2CCc2ccc(NC(=O)OC(C)(C)C)cc21 | Homo sapiens | CHEMBL3767622 | single protein format |
| CHEMBL3764215 |  |
IC50 | = | 116.4 | nM | 437.58 | CCCN(CCC)CC(=O)N1c2ccccc2CCc2ccc(NC(=O)OC(C)C)cc21 | Homo sapiens | CHEMBL3767622 | single protein format |
| CHEMBL3764619 |  |
IC50 | = | 152.9 | nM | 451.61 | CCCN(CCC)CC(=O)N1c2ccccc2CCc2ccc(NC(=O)OC(C)(C)C)cc21 | Homo sapiens | CHEMBL3767622 | single protein format |
| CHEMBL3764049 |  |
IC50 | = | 210.0 | nM | 423.56 | CCCN(CCC)CC(=O)N1c2ccccc2CCc2ccc(NC(=O)OCC)cc21 | Homo sapiens | CHEMBL3767622 | single protein format |
| CHEMBL3764753 |  |
IC50 | = | 216.2 | nM | 435.57 | CC(C)(C)OC(=O)Nc1ccc2c(c1)N(C(=O)CN1CCCCC1)c1ccccc1CC2 | Homo sapiens | CHEMBL3767622 | single protein format |