Q14703 | MBTP1_HUMAN | Membrane-bound transcription factor site-1 protease (MBTPS1)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00082 | Peptidase_S8 - Subtilase family | 209~464 | |
| PF23001 | MBTP1_N - Membrane-bound Site-1 Protease Family N-terminal domain | 51~130 | |
| PF23090 | MBTPS1_4th - MBTPS1, fourth GATase-like domain | 617~880 | |
| PF23094 | MBTPS1_3rd - MBTPS1, third Ig-like domain | 485~616 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL391935 |  |
IC50 | = | 8.0 | nM | 516.13 | Cc1ccccc1C1CCCN(Cc2ccc(C(=O)N(CCc3ccccc3Cl)C3CCNC3)cc2)C1 | Homo sapiens | CHEMBL896780 | cell-based format |
| CHEMBL233987 |  |
IC50 | = | 29.0 | nM | 447.62 | COc1ccccc1CCN(C(=O)c1ccc(CN2CC3CCCC2C3)cc1)C1CCNC1 | Homo sapiens | CHEMBL896780 | cell-based format |
| CHEMBL233799 |  |
IC50 | = | 37.0 | nM | 511.71 | COc1ccccc1CCN(C(=O)c1ccc(CN2CCCC(c3ccccc3C)C2)cc1)C1CCNC1 | Homo sapiens | CHEMBL896780 | cell-based format |
| CHEMBL233421 |  |
IC50 | = | 95.0 | nM | 433.6 | COc1ccccc1CCN(C(=O)c1ccc(CN2CC3CCC2C3)cc1)C1CCNC1 | Homo sapiens | CHEMBL896780 | cell-based format |
| CHEMBL233422 |  |
IC50 | = | 100.0 | nM | 451.61 | COc1ccccc1CCN(C(=O)c1ccc(CN[C@H]2CCCC[C@@H]2O)cc1)C1CCNC1 | Homo sapiens | CHEMBL896780 | cell-based format |
| CHEMBL233609 |  |
IC50 | = | 140.0 | nM | 451.61 | COC[C@@H]1CCCN1Cc1ccc(C(=O)N(CCc2ccccc2OC)C2CCNC2)cc1 | Homo sapiens | CHEMBL896780 | cell-based format |
| CHEMBL233610 |  |
IC50 | = | 160.0 | nM | 464.61 | COc1ccccc1CCN(C(=O)c1ccc(CN2CCCC(C(N)=O)C2)cc1)C1CCNC1 | Homo sapiens | CHEMBL896780 | cell-based format |
| CHEMBL233611 |  |
IC50 | = | 170.0 | nM | 409.57 | CCN(CC)Cc1ccc(C(=O)N(CCc2ccccc2OC)[C@@H]2CCNC2)cc1 | Homo sapiens | CHEMBL896780 | cell-based format |
| CHEMBL394028 |  |
IC50 | = | 250.0 | nM | 421.59 | COc1ccccc1CCN(C(=O)c1ccc(CN2CCCCC2)cc1)C1CCNC1 | Homo sapiens | CHEMBL896780 | cell-based format |
| CHEMBL393989 |  |
IC50 | = | 310.0 | nM | 430.55 | COc1ccccc1CCN(C(=O)c1ccc(OCc2ccccc2)cc1)C1CCNC1 | Homo sapiens | CHEMBL896780 | cell-based format |
| CHEMBL232587 |  |
IC50 | = | 430.0 | nM | 448.44 | CCN(CC)Cc1ccc(C(=O)N(CCc2c(Cl)cccc2Cl)C2CCNC2)cc1 | Homo sapiens | CHEMBL896780 | cell-based format |
| CHEMBL232777 |  |
IC50 | = | 510.0 | nM | 434.97 | O=C(c1ccc(OCc2ccccc2)cc1)N(CCc1cccc(Cl)c1)C1CCNC1 | Homo sapiens | CHEMBL896780 | cell-based format |
| CHEMBL231776 |  |
IC50 | = | 540.0 | nM | 409.57 | CCN(CC)Cc1ccc(C(=O)N(CCc2ccccc2OC)C2CCNC2)cc1 | Homo sapiens | CHEMBL896780 | cell-based format |
| CHEMBL233573 |  |
IC50 | = | 590.0 | nM | 434.97 | O=C(c1ccc(OCc2ccccc2)cc1)N(CCc1ccccc1Cl)C1CCNC1 | Homo sapiens | CHEMBL896780 | cell-based format |
| CHEMBL233572 |  |
IC50 | = | 840.0 | nM | 413.99 | CCN(CC)Cc1ccc(C(=O)N(CCc2ccccc2Cl)C2CCNC2)cc1 | Homo sapiens | CHEMBL896780 | cell-based format |
| CHEMBL394029 |  |
IC50 | = | 970.0 | nM | 409.57 | CCN(CC)Cc1ccc(C(=O)N(CCc2ccccc2OC)[C@H]2CCNC2)cc1 | Homo sapiens | CHEMBL896780 | cell-based format |