Q14573 | ITPR3_HUMAN | Inositol 1,4,5-trisphosphate receptor type 3 (ITPR3)

Helixβ‑strandTurn secondary structure

Pfam Domain Table

AccessionDomainRangeColor
PF00520Ion_trans2239–2527
PF01365RYDR_ITPR474–670
PF01365RYDR_ITPR1188–1327
PF02815MIR234–431
PF08454RIH_assoc1867–1973
PF08709Ins145_P3_rec4–229

 3D structures mapped by conservation among orthologs


 [ Alpha Fold Model ] (go)



 Known binders annotated in ChEMBL

 IC50 CSV
Only the first 20 rows are shown.
molecule_chembl_idstructureassay_typerelation valueunitmol_wtsmilesorganism assay_chembl_idbao_label
CHEMBL23552 IC50 = 2.9 nM 500.07 O=P(O)(O)O[C@H]1[C@H](O)[C@@H](OP(=O)(O)O)[C@H](OP(=O)(O)O)[C@@H](OP(=O)(O)O)[C@H]1O Homo sapiens CHEMBL697185 tissue-based format
CHEMBL283791 IC50 = 6.1 nM 420.09 O=P(O)(O)O[C@H]1[C@H](OP(=O)(O)O)[C@@H](O)[C@H](O)[C@H](O)[C@@H]1OP(=O)(O)O Homo sapiens CHEMBL697185 tissue-based format
CHEMBL281132 IC50 = 44.0 nM 434.12 C[C@]1(OP(=O)(O)O)[C@H](OP(=O)(O)O)[C@H](O)[C@H](O)[C@@H](O)[C@@H]1OP(=O)(O)O Homo sapiens CHEMBL697185 tissue-based format
CHEMBL282059 IC50 = 430.0 nM 500.07 O=P(O)(O)O[C@@H]1[C@@H](OP(=O)(O)O)[C@H](OP(=O)(O)O)[C@@H](O)[C@@H](O)[C@H]1OP(=O)(O)O Homo sapiens CHEMBL697185 tissue-based format
CHEMBL23050 IC50 = 620.0 nM 500.07 O=P(O)(O)O[C@H]1[C@H](OP(=O)(O)O)[C@@H](OP(=O)(O)O)[C@@H](O)[C@@H](O)[C@@H]1OP(=O)(O)O Homo sapiens CHEMBL697185 tissue-based format