Q14524 | SCN5A_HUMAN | Sodium channel protein type 5 subunit alpha (SCN5A)

Pfam Domain Table

AccessionDomainRangeColor
PF00520Ion_trans - Ion transport protein130~422
PF00520Ion_trans - Ion transport protein717~945
PF00520Ion_trans - Ion transport protein1204~1479
PF00520Ion_trans - Ion transport protein1528~1782
PF06512Na_trans_assoc - Sodium ion transport-associated953~1200
PF11933Na_trans_cytopl - Cytoplasmic domain of voltage-gated Na+ ion channel508~667
PF24609IQ_SCN5A_C - SCN5A-like, C-terminal IQ motif1894~1926

3D structures mapped by conservation among orthologs

[ Domain: "EF-hand" // EF-hand_7_6 ]

 PyMOL session

[ Domain: "Voltage gated calcium channel IQ domain" // IQ_like ]

 PyMOL session


[ Alpha Fold Model ] (go)



Known binders annotated in ChEMBL

 IC50 CSV    Ki CSV
Only the first 20 rows are shown.
molecule_chembl_idstructureassay_typerelation valueunitmol_wtsmilesorganism assay_chembl_idbao_label
CHEMBL3617050 IC50 = 0.28 nM 552.48 N=C1N[C@@]23[C@H]([C@H]4NC(=N)N2C[C@](OS(=O)(=O)O)(C[C@H]2[C@@H](CO)CON2C4=O)C3(O)O)N1COC(=O)NO Homo sapiens CHEMBL3618799 cell-based format
CHEMBL4061793 IC50 = 2.2 nM 430.96 O=S(=O)(Nc1nccs1)c1cc(Cl)c(NCC23CCCN2CCC3)cc1F Homo sapiens CHEMBL4046487 cell-based format
CHEMBL4444707 IC50 = 3.2 nM 563.01 CS(=O)(=O)NC(=O)c1cc(C2CC2)c(OCC2CCN(Cc3cc(C(F)(F)F)ccc3Cl)CC2)cc1F Homo sapiens CHEMBL5225022 single protein format
CHEMBL3657939 IC50 = 14.0 nM 492.61 O=C(NS(=O)(=O)N1CCOCC1)c1cc(C2CC2)c(OCC23CC4CC(CC(C4)C2)C3)cc1F Homo sapiens CHEMBL3705543 cell-based format
CHEMBL3657952 IC50 = 22.0 nM 480.6 O=C(NS(=O)(=O)NCCCO)c1cc(C2CC2)c(OCC23CC4CC(CC(C4)C2)C3)cc1F Homo sapiens CHEMBL3705543 cell-based format
CHEMBL3657932 IC50 = 26.0 nM 447.57 O=C(NS(=O)(=O)C1CC1)c1cc(C2CC2)c(OCC23CC4CC(CC(C4)C2)C3)cc1F Homo sapiens CHEMBL3705543 cell-based format
CHEMBL3677849 IC50 = 30.0 nM 515.54 Cn1nccc1-c1cc(C(F)(F)F)ccc1-c1cccc2cc(S(=O)(=O)Nc3ncns3)ccc12 Homo sapiens CHEMBL3705623 cell-based format
CHEMBL4864812 IC50 = 31.0 nM 599.48 O=S(=O)(Nc1cccc(F)n1)c1cc(F)c(O[C@H]2CCN(CC(F)(F)F)C[C@@H]2c2ccc(F)c(F)c2)c(F)c1F Homo sapiens CHEMBL4813111 single protein format
CHEMBL4075332 IC50 = 37.0 nM 468.0 O=S1(=O)CCC(CCNc2cc(F)c(S(=O)(=O)Nc3nccs3)cc2Cl)CC1 Homo sapiens CHEMBL4046487 cell-based format
CHEMBL3662238 IC50 = 40.0 nM 410.51 O=C(NS(=O)(=O)N1CCC1)c1cc(C2CC2)c(OCC2CCCCC2)cc1F Homo sapiens CHEMBL3705543 cell-based format
CHEMBL3662190 IC50 = 50.0 nM 435.56 CC1(COc2cc(F)c(C(=O)NS(=O)(=O)C3CC3)cc2C2CC2)CCC2(CC1)CC2 Homo sapiens CHEMBL4321995 cell-based format
CHEMBL4094490 IC50 = 50.0 nM 419.93 O=S(=O)(Nc1nccs1)c1cc(Cl)c(NCCC2CCCOC2)cc1F Homo sapiens CHEMBL4046487 cell-based format
CHEMBL3657855 IC50 = 51.5 nM 462.59 O=C(NS(=O)(=O)N1CCC1)c1cc(C2CC2)c(OCC23CC4CC(CC(C4)C2)C3)cc1F Homo sapiens CHEMBL3705543 cell-based format
CHEMBL4102624 IC50 = 52.0 nM 417.92 O=C1CCCC(CNc2cc(F)c(S(=O)(=O)Nc3nccs3)cc2Cl)C1 Homo sapiens CHEMBL4046487 cell-based format
CHEMBL3810248 IC50 = 59.0 nM 335.41 C[Si](C)(C)c1ccc(-c2ccc3nnc(C(F)(F)F)n3c2)cc1 Homo sapiens CHEMBL3811490 single protein format
CHEMBL3657838 IC50 = 60.6 nM 478.59 O=C(NS(=O)(=O)N1CC(O)C1)c1cc(C2CC2)c(OCC23CC4CC(CC(C4)C2)C3)cc1F Homo sapiens CHEMBL3705543 cell-based format
CHEMBL4854735 IC50 = 65.0 nM 581.49 O=S(=O)(Nc1cccc(F)n1)c1cc(F)c(O[C@H]2CCN(CC(F)(F)F)C[C@@H]2c2ccc(F)c(F)c2)c(F)c1 Homo sapiens CHEMBL4813111 single protein format
CHEMBL4087220 IC50 = 74.0 nM 407.88 O=S(=O)(Nc1nccs1)c1cc(Cl)c(NCC2COCCO2)cc1F Homo sapiens CHEMBL4046487 cell-based format
CHEMBL4072883 IC50 = 76.0 nM 405.9 O=S(=O)(Nc1nccs1)c1cc(Cl)c(NC[C@H]2CCCOC2)cc1F Homo sapiens CHEMBL4046487 cell-based format
CHEMBL4102233 IC50 = 77.0 nM 482.0 O=S(=O)(Nc1nccs1)c1cc(Cl)c(NC[C@H]2CCCO[C@@H]2c2ccccc2)cc1F Homo sapiens CHEMBL4046487 cell-based format