Q14432 | PDE3A_HUMAN | cGMP-inhibited 3',5'-cyclic phosphodiesterase A (PDE3A)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00233 | PDEase_I - 3'5'-cyclic nucleotide phosphodiesterase | 820~1015 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL339210 |  |
IC50 | = | 0.11 | nM | 469.61 | C[C@@H]1CC(=O)NN=C1c1ccc(NC2=C(Cc3ccccc3-c3ccsc3)C(=O)CCC2)cc1 | Homo sapiens | CHEMBL761480 | assay format |
| CHEMBL338860 |  |
IC50 | = | 0.11 | nM | 508.58 | C[C@@H]1CC(=O)NN=C1c1ccc(NC2=C(Cc3ccccc3-c3cccc([N+](=O)[O-])c3)C(=O)CCC2)cc1 | Homo sapiens | CHEMBL761480 | assay format |
| CHEMBL2337969 |  |
IC50 | = | 0.27 | nM | 530.63 | CCc1cc2c(C3=NN(CCCCOc4ccc(C5=NNC(=O)CC5C)cc4)C(=O)CC3)ccc(OC)n2n1 | Homo sapiens | CHEMBL2343517 | single protein format |
| CHEMBL131355 |  |
IC50 | = | 0.33 | nM | 513.38 | CC1CC(=O)NN=C1c1ccc(NC2=C(Cc3cccc(I)c3)C(=O)CCC2)cc1 | Homo sapiens | CHEMBL761480 | assay format |
| CHEMBL131111 |  |
IC50 | = | 0.39 | nM | 417.51 | COc1ccccc1CC1=C(Nc2ccc(C3=NNC(=O)CC3C)cc2)CCCC1=O | Homo sapiens | CHEMBL761480 | assay format |
| CHEMBL338381 |  |
IC50 | = | 0.83 | nM | 455.48 | CC1CC(=O)NN=C1c1ccc(NC2=C(Cc3ccccc3C(F)(F)F)C(=O)CCC2)cc1 | Homo sapiens | CHEMBL761480 | assay format |
| CHEMBL128621 |  |
IC50 | = | 0.94 | nM | 466.38 | CC1CC(=O)NN=C1c1ccc(NC2=C(Cc3cccc(Br)c3)C(=O)CCC2)cc1 | Homo sapiens | CHEMBL761480 | assay format |
| CHEMBL128391 |  |
IC50 | = | 1.2 | nM | 405.47 | CC1CC(=O)NN=C1c1ccc(/N=C2\CCCC(O)=C2Cc2ccccc2)c(F)c1 | Homo sapiens | CHEMBL761480 | assay format |
| CHEMBL2337953 |  |
IC50 | = | 1.2 | nM | 544.66 | CCc1cc2c(C3=NN(CCCCOc4ccc(C5=NNC(=O)CC5C)cc4)C(=O)CC3C)ccc(OC)n2n1 | Homo sapiens | CHEMBL2343517 | single protein format |
| CHEMBL128456 |  |
IC50 | = | 1.3 | nM | 387.48 | C[C@@H]1CC(=O)NN=C1c1ccc(NC2=C(Cc3ccccc3)C(=O)CCC2)cc1 | Homo sapiens | CHEMBL761480 | assay format |
| CHEMBL130026 |  |
IC50 | = | 1.6 | nM | 423.46 | CC1CC(=O)NN=C1c1cc(F)c(NC2=C(Cc3ccccc3)C(=O)CCC2)cc1F | Homo sapiens | CHEMBL761480 | assay format |
| CHEMBL338179 |  |
IC50 | = | 1.6 | nM | 405.47 | CC1CC(=O)NN=C1c1ccc(NC2=C(Cc3ccccc3)C(=O)CCC2)cc1F | Homo sapiens | CHEMBL761480 | assay format |
| CHEMBL2337971 |  |
IC50 | = | 1.7 | nM | 544.66 | CCc1cc2c(C3=NN(CCCCOc4ccc(C5=NNC(=O)CC5C)cc4)C(=O)C3(C)C)ccc(OC)n2n1 | Homo sapiens | CHEMBL2343517 | single protein format |
| CHEMBL4741180 |  |
IC50 | = | 1.89 | nM | 353.35 | Nc1nc2c(ncn2CCCOc2ccc(-c3nnn[nH]3)cc2)c(=O)[nH]1 | Homo sapiens | CHEMBL4726107 | cell-based format |
| CHEMBL4758355 |  |
IC50 | = | 2.17 | nM | 337.35 | Nc1ncnc2c1ncn2CCCOc1ccc(-c2nnn[nH]2)cc1 | Homo sapiens | CHEMBL4726107 | cell-based format |
| CHEMBL129668 |  |
IC50 | = | 2.2 | nM | 474.36 | CC1(C)C(=O)NN=C1c1ccc(NC2=C(Cc3c(Cl)cccc3Cl)C(=O)CCC2)cc1F | Homo sapiens | CHEMBL761480 | assay format |
| CHEMBL129255 |  |
IC50 | = | 2.3 | nM | 417.51 | COc1ccc(CC2=C(Nc3ccc(C4=NNC(=O)CC4C)cc3)CCCC2=O)cc1 | Homo sapiens | CHEMBL761480 | assay format |
| CHEMBL4783647 |  |
IC50 | = | 2.41 | nM | 328.33 | O=c1ccn(CCCCOc2ccc(-c3nnn[nH]3)cc2)c(=O)[nH]1 | Homo sapiens | CHEMBL4726107 | cell-based format |
| CHEMBL2337970 |  |
IC50 | = | 2.7 | nM | 528.61 | CCc1cc2c(-c3ccc(=O)n(CCCCOc4ccc(C5=NNC(=O)CC5C)cc4)n3)ccc(OC)n2n1 | Homo sapiens | CHEMBL2343517 | single protein format |
| CHEMBL341231 |  |
IC50 | = | 2.8 | nM | 405.47 | CC1CC(=O)NN=C1c1ccc(NC2=C(Cc3cccc(F)c3)C(=O)CCC2)cc1 | Homo sapiens | CHEMBL761480 | assay format |