Q14416 | GRM2_HUMAN | Metabotropic glutamate receptor 2 (GRM2)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00003 | 7tm_3 - 7 transmembrane sweet-taste receptor of 3 GCPR | 562~813 | |
| PF01094 | ANF_receptor - Receptor family ligand binding region | 61~458 | |
| PF07562 | NCD3G - Nine Cysteines Domain of family 3 GPCR | 496~546 |
3D structures mapped by conservation among orthologs
[ Domain: "Periplasmic binding protein-like I" // ANF_receptor_2nd_1 ]
[ Domain: "TNF receptor-like" // NCD3G ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL409928 |  |
IC50 | = | 3.49 | nM | 371.36 | N[C@](CC1c2ccccc2Oc2ccccc21)(C(=O)O)[C@H]1C[C@]1(F)C(=O)O | Homo sapiens | CHEMBL929194 | cell-based format |
| CHEMBL3945590 |  |
IC50 | = | 4.0 | nM | 416.46 | COc1ccc(-c2cc(C(N)=O)nc3cc(CCc4cnc(C)nc4)ccc23)cc1F | Homo sapiens | CHEMBL3888122 | cell-based format |
| CHEMBL259435 |  |
IC50 | = | 4.45 | nM | 371.36 | NC(CC1c2ccccc2Oc2ccccc21)(C(=O)O)C1CC1(F)C(=O)O | Homo sapiens | CHEMBL929194 | cell-based format |
| CHEMBL3964644 |  |
IC50 | = | 5.0 | nM | 387.41 | NC(=O)c1cc(-c2ccc(F)cc2)c2ccc(C(O)Cc3cccnc3)cc2n1 | Homo sapiens | CHEMBL3888122 | cell-based format |
| CHEMBL3971388 |  |
IC50 | = | 5.0 | nM | 373.41 | Cc1ccc(-c2cc(C(N)=O)nc3cc(CN4C(=O)CCC4=O)ccc23)cc1 | Homo sapiens | CHEMBL3888122 | cell-based format |
| CHEMBL3923126 |  |
IC50 | = | 5.0 | nM | 434.45 | COc1cc(F)c(-c2cc(C(N)=O)nc3cc(CCc4cnc(C)nc4)ccc23)c(F)c1 | Homo sapiens | CHEMBL3888122 | cell-based format |
| CHEMBL2206447 |  |
IC50 | = | 5.6 | nM | 432.9 | COc1cc(F)cc(F)c1C1CCN(c2ccn3c(CC4CC4)nnc3c2Cl)CC1 | Homo sapiens | CHEMBL2215921 | cell-based format |
| CHEMBL3955188 |  |
IC50 | = | 6.0 | nM | 416.46 | COc1ccc(-c2cc(C(N)=O)nc3cc(CCc4cnc(C)nc4)ccc23)c(F)c1 | Homo sapiens | CHEMBL3888122 | cell-based format |
| CHEMBL3941863 |  |
IC50 | = | 6.0 | nM | 427.44 | COc1ccc(-c2cc(C(N)=O)nc3cc(CCc4cnc(C#N)nc4)ccc23)c(F)c1 | Homo sapiens | CHEMBL3888122 | cell-based format |
| CHEMBL3983863 |  |
IC50 | = | 6.0 | nM | 411.39 | Cn1cc(-c2cc(C(N)=O)nc3cc(Cc4ccnc(C(F)(F)F)c4)ccc23)cn1 | Homo sapiens | CHEMBL3888122 | cell-based format |
| CHEMBL3973721 |  |
IC50 | = | 7.0 | nM | 430.48 | COc1ccc(-c2cc(C(N)=O)nc3cc(C(C)Cc4cnc(C)nc4)ccc23)c(F)c1 | Homo sapiens | CHEMBL3888122 | cell-based format |
| CHEMBL3958138 |  |
IC50 | = | 7.0 | nM | 377.44 | CC1CC=C(c2cc(C(N)=O)nc3cc(CN4C(=O)CCC4=O)ccc23)CC1 | Homo sapiens | CHEMBL3888122 | cell-based format |
| CHEMBL8759 |  |
IC50 | = | 7.0 | nM | 185.18 | N[C@@]1(C(=O)O)CC[C@H]2[C@H](C(=O)O)[C@H]21 | Homo sapiens | CHEMBL4719943 | single protein format |
| CHEMBL3937970 |  |
IC50 | = | 7.0 | nM | 409.45 | COc1ccc(-c2cc(C(N)=O)nc3cc(CCc4cnc(C#N)nc4)ccc23)cc1 | Homo sapiens | CHEMBL3888122 | cell-based format |
| CHEMBL3925177 |  |
IC50 | = | 7.0 | nM | 399.45 | COc1ccc(-c2cc(C(N)=O)nc3cc(CCc4cncnc4N)ccc23)cc1 | Homo sapiens | CHEMBL3888122 | cell-based format |
| CHEMBL3961599 |  |
IC50 | = | 7.0 | nM | 445.83 | Cn1cc(-c2cc(C(N)=O)nc3cc(Cc4cc(Cl)nc(C(F)(F)F)c4)ccc23)cn1 | Homo sapiens | CHEMBL3888122 | cell-based format |
| CHEMBL3950572 |  |
IC50 | = | 7.0 | nM | 372.4 | NC(=O)c1cc(-c2ccc(F)cc2)c2ccc(CCc3cncnc3)cc2n1 | Homo sapiens | CHEMBL3888122 | cell-based format |
| CHEMBL2206446 |  |
IC50 | = | 7.3 | nM | 432.9 | COc1ccc(F)c(F)c1C1CCN(c2ccn3c(CC4CC4)nnc3c2Cl)CC1 | Homo sapiens | CHEMBL2215921 | cell-based format |
| CHEMBL3971450 |  |
IC50 | = | 8.0 | nM | 423.48 | COc1ccc(-c2cc(C(N)=O)nc3cc(C(C)Cc4cnc(C#N)nc4)ccc23)cc1 | Homo sapiens | CHEMBL3888122 | cell-based format |
| CHEMBL3894283 |  |
IC50 | = | 8.0 | nM | 407.4 | COc1ccc(-c2cc(C(N)=O)nc3cc(CN4C(=O)CCC4=O)ccc23)c(F)c1 | Homo sapiens | CHEMBL3888122 | cell-based format |