Q14397 | GCKR_HUMAN | Glucokinase regulatory protein (GCKR)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF20741 | GKRP-like_C - C-terminal lid domain of glucokinase regulatory protein | 502~601 | |
| PF22198 | GKRP_SIS_2 - Glucokinase regulatory protein, second SIS domain | 307~496 | |
| PF22645 | GKRP_SIS_N - Glucokinase regulatory protein N-terminal SIS domain | 85~195 |
3D structures mapped by conservation among orthologs
[ Domain: "C-terminal lid domain of glucokinase regulatory protein" // murQ_2nd ]
[ Domain: "C-terminal lid domain of glucokinase regulatory protein" // murQ_2nd,murQ_1st ]
[ Domain: "Ribosomal protein S2/SIS domain" // PRK12570 ]
[ Domain: "Ribosomal protein S2/SIS domain" // murQ_1st ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL3746243 |  |
IC50 | = | 3.8 | nM | 547.08 | CC(C)(O)c1ccnc(-c2cccc3cc([C@H](NS(=O)(=O)C4CC4)c4c(Cl)cnc(N)c4F)sc23)c1 | Homo sapiens | CHEMBL3751192 | single protein format |
| CHEMBL3114185 |  |
IC50 | = | 4.0 | nM | 522.47 | CC#C[C@H]1CN(S(=O)(=O)c2ccc(N)nc2)CCN1c1ccc(C(O)(C(F)(F)F)C(F)(F)F)cc1 | Homo sapiens | CHEMBL3240701 | single protein format |
| CHEMBL3237987 |  |
IC50 | = | 5.0 | nM | 506.55 | CC#CCC(O)(c1ccc(N2CCN(S(=O)(=O)c3ccc(N)nc3)C[C@@H]2C#CC)cc1)C(F)(F)F | Homo sapiens | CHEMBL3240701 | single protein format |
| CHEMBL3745887 |  |
IC50 | = | 6.0 | nM | 529.09 | CC(C)(O)c1ccnc(-c2cccc3cc([C@H](NS(=O)(=O)C4CC4)c4nc(N)ccc4Cl)sc23)c1 | Homo sapiens | CHEMBL3751192 | single protein format |
| CHEMBL3237986 |  |
IC50 | = | 6.0 | nM | 492.52 | C#CCC(O)(c1ccc(N2CCN(S(=O)(=O)c3ccc(N)nc3)C[C@@H]2C#CC)cc1)C(F)(F)F | Homo sapiens | CHEMBL3240701 | single protein format |
| CHEMBL3237981 |  |
IC50 | = | 6.0 | nM | 484.5 | CC#C[C@H]1CN(S(=O)(=O)c2ccc(N)nc2)CCN1c1ccc([C@@](O)(CO)C(F)(F)F)cc1 | Homo sapiens | CHEMBL3240701 | single protein format |
| CHEMBL3114187 |  |
IC50 | = | 9.0 | nM | 468.5 | CC#C[C@H]1CN(S(=O)(=O)c2ccc(N)nc2)CCN1c1ccc([C@@](C)(O)C(F)(F)F)cc1 | Homo sapiens | CHEMBL3240701 | single protein format |
| CHEMBL3127349 |  |
IC50 | = | 9.7 | nM | 587.61 | C[C@H]1COCCN1C[C@H]1CN(S(=O)(=O)c2cccs2)CCN1c1ccc(C(O)(C(F)(F)F)C(F)(F)F)cc1 | Homo sapiens | CHEMBL3131528 | single protein format |
| CHEMBL3238310 |  |
IC50 | = | 10.0 | nM | 524.45 | CC#C[C@H]1CN(S(=O)(=O)c2ccc(N)nc2)CCN1c1ncc(C(O)(C(F)(F)F)C(F)(F)F)cn1 | Homo sapiens | CHEMBL3240701 | single protein format |
| CHEMBL3238309 |  |
IC50 | = | 10.0 | nM | 523.46 | CC#C[C@H]1CN(S(=O)(=O)c2ccc(N)nc2)CCN1c1ccc(C(O)(C(F)(F)F)C(F)(F)F)cn1 | Homo sapiens | CHEMBL3240701 | single protein format |
| CHEMBL3746444 |  |
IC50 | = | 11.0 | nM | 547.08 | CC(C)(O)c1ccnc(-c2cccc3cc([C@H](NS(=O)(=O)C4CC4)c4nc(N)c(F)cc4Cl)sc23)c1 | Homo sapiens | CHEMBL3751192 | single protein format |
| CHEMBL3127352 |  |
IC50 | = | 12.0 | nM | 533.64 | C[C@H]1COCCN1C[C@H]1CN(S(=O)(=O)c2cccs2)CCN1c1ccc([C@](C)(O)C(F)(F)F)cc1 | Homo sapiens | CHEMBL3131528 | single protein format |
| CHEMBL3238313 |  |
IC50 | = | 13.0 | nM | 485.49 | CC#C[C@H]1CN(S(=O)(=O)c2ccc(N)nc2)CCN1c1ccc([C@](O)(CO)C(F)(F)F)cn1 | Homo sapiens | CHEMBL3240701 | single protein format |
| CHEMBL3238308 |  |
IC50 | = | 13.0 | nM | 469.49 | CC#C[C@H]1CN(S(=O)(=O)c2ccc(N)nc2)CCN1c1ccc([C@](C)(O)C(F)(F)F)cn1 | Homo sapiens | CHEMBL3240701 | single protein format |
| CHEMBL3238307 |  |
IC50 | = | 13.0 | nM | 469.49 | CC#C[C@H]1CN(S(=O)(=O)c2ccc(N)nc2)CCN1c1ccc([C@@](C)(O)C(F)(F)F)cn1 | Homo sapiens | CHEMBL3240701 | single protein format |
| CHEMBL3237985 |  |
IC50 | = | 16.0 | nM | 498.53 | CC#C[C@H]1CN(S(=O)(=O)c2ccc(N)nc2)CCN1c1ccc(C(O)(COC)C(F)(F)F)cc1 | Homo sapiens | CHEMBL3240701 | single protein format |
| CHEMBL3746456 |  |
IC50 | = | 17.0 | nM | 486.01 | O=S(=O)(N[C@@H](c1cc2ccccc2s1)c1ccccc1Cl)c1ccc2c(c1)OCCCO2 | Homo sapiens | CHEMBL3751192 | single protein format |
| CHEMBL3238303 |  |
IC50 | = | 17.0 | nM | 487.53 | CC#C[C@H]1CN(S(=O)(=O)c2ccc(N)nc2)CCN1c1ccc([S@](=N)(=O)C(F)(F)F)cc1 | Homo sapiens | CHEMBL3240701 | single protein format |
| CHEMBL3746034 |  |
IC50 | = | 18.0 | nM | 530.08 | CC(C)(O)c1ccnc(-c2cccc3cc([C@H](NS(=O)(=O)C4CC4)c4nc(N)ncc4Cl)sc23)c1 | Homo sapiens | CHEMBL3751192 | single protein format |
| CHEMBL3238306 |  |
IC50 | = | 18.0 | nM | 469.49 | CC#C[C@H]1CN(S(=O)(=O)c2ccc(N)nc2)CCN1c1ccc(C(C)(O)C(F)(F)F)cn1 | Homo sapiens | CHEMBL3240701 | single protein format |