Q14164 | IKKE_HUMAN | Inhibitor of nuclear factor kappa-B kinase subunit epsilon (IKBKE)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00069 | Pkinase - Protein kinase domain | 10~223 | |
| PF18394 | TBK1_CCD1 - TANK-binding kinase 1 coiled-coil domain 1 | 400~645 | |
| PF18396 | TBK1_ULD - TANK binding kinase 1 ubiquitin-like domain | 308~392 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL388978 |  |
IC50 | = | 0.439 | nM | 466.54 | CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 | Homo sapiens | CHEMBL4328452 | single protein format |
| CHEMBL3218297 |  |
IC50 | < | 1.0 | nM | 422.49 | CS(=O)(=O)O.O=C(NCc1cccc(O)c1)Nc1nc(-c2ccncc2)cs1 | Homo sapiens | CHEMBL3224484 | single protein format |
| CHEMBL3682430 |  |
IC50 | = | 1.0 | nM | 455.56 | N#Cc1cc(-c2ccnc(Nc3cc(C4CCNCC4)ccn3)c2)ccc1OC1CCOCC1 | Homo sapiens | CHEMBL3707546 | single protein format |
| CHEMBL4537673 |  |
IC50 | = | 2.0 | nM | 553.59 | C[C@H](c1ccnc(Nc2nc3ccc(-c4cc(N(C)C)ncn4)cc3[nH]2)c1)N1CCN(C(=O)CC(F)(F)F)CC1 | Homo sapiens | CHEMBL4380519 | assay format |
| CHEMBL3687186 |  |
IC50 | = | 2.0 | nM | 473.58 | N#Cc1cc(-c2ccnc(Nc3cnn(CCC4CCNCC4)c3)n2)ccc1OC1CCOCC1 | Homo sapiens | CHEMBL3707546 | single protein format |
| CHEMBL4566796 |  |
IC50 | = | 2.0 | nM | 554.58 | COCc1cc(-c2ccc3nc(Nc4cc([C@@H](C)N5CCN(C(=O)CC(F)(F)F)CC5)ccn4)[nH]c3c2)ncn1 | Homo sapiens | CHEMBL4380519 | assay format |
| CHEMBL3682423 |  |
IC50 | = | 4.0 | nM | 446.51 | N#Cc1cc(-c2ccnc(Nc3cnn(C[C@H]4C[C@@H]4CO)c3)n2)ccc1OC1CCOCC1 | Homo sapiens | CHEMBL3707546 | single protein format |
| CHEMBL2011940 |  |
IC50 | = | 4.0 | nM | 443.35 | Nc1cccc(-c2nc3c(NCCCNC(=O)C4CCC4)c(Br)cnc3[nH]2)c1 | Homo sapiens | CHEMBL2013354 | single protein format |
| CHEMBL4436188 |  |
IC50 | = | 4.0 | nM | 566.63 | C[C@H](c1ccnc(Nc2nc3ccc(-c4cnn(CC5CCC5)c4)cc3[nH]2)c1)N1CCN(C(=O)CC(F)(F)F)CC1 | Homo sapiens | CHEMBL4380519 | assay format |
| CHEMBL3682431 |  |
IC50 | = | 4.0 | nM | 406.45 | N#Cc1cc(-c2ccnc(Nc3cnn(CCO)c3)n2)ccc1OC1CCOCC1 | Homo sapiens | CHEMBL3707546 | single protein format |
| CHEMBL4454902 |  |
IC50 | = | 4.0 | nM | 580.62 | C[C@H](c1ccnc(Nc2nc3ccc(-c4cc(OCC5CC5)ncn4)cc3[nH]2)c1)N1CCN(C(=O)CC(F)(F)F)CC1 | Homo sapiens | CHEMBL4380519 | assay format |
| CHEMBL4538751 |  |
IC50 | = | 4.0 | nM | 524.55 | Cc1cc(-c2ccc3nc(Nc4cc([C@@H](C)N5CCN(C(=O)CC(F)(F)F)CC5)ccn4)[nH]c3c2)ncn1 | Homo sapiens | CHEMBL4380519 | assay format |
| CHEMBL3639859 |  |
IC50 | = | 5.0 | nM | 460.54 | N#Cc1cc(-c2ccnc(Nc3cnn([C@H]4CC[C@H](O)CC4)c3)n2)ccc1OC1CCOCC1 | Homo sapiens | CHEMBL3707546 | single protein format |
| CHEMBL2011932 |  |
IC50 | = | 5.0 | nM | 473.38 | COc1ccc(-c2nc3c(NCCCNC(=O)C4(CN)CC4)c(Br)cnc3[nH]2)cc1 | Homo sapiens | CHEMBL2013354 | single protein format |
| CHEMBL3687181 |  |
IC50 | = | 5.0 | nM | 431.5 | N#Cc1cc(-c2ccnc(Nc3cnn(C4CCNC4)c3)n2)ccc1OC1CCOCC1 | Homo sapiens | CHEMBL3707546 | single protein format |
| CHEMBL3682420 |  |
IC50 | = | 6.0 | nM | 445.53 | N#Cc1cc(-c2ccnc(Nc3cnn(C4CCNCC4)c3)n2)ccc1OC1CCOCC1 | Homo sapiens | CHEMBL3707546 | single protein format |
| CHEMBL3687175 |  |
IC50 | = | 6.0 | nM | 362.39 | N#Cc1cc(-c2ccnc(Nc3cn[nH]c3)n2)ccc1OC1CCOCC1 | Homo sapiens | CHEMBL3707546 | single protein format |
| CHEMBL3682434 |  |
IC50 | = | 6.0 | nM | 469.59 | CN1CCC(c2ccnc(Nc3cc(-c4ccc(OC5CCOCC5)c(C#N)c4)ccn3)c2)CC1 | Homo sapiens | CHEMBL3707546 | single protein format |
| CHEMBL3682427 |  |
IC50 | = | 6.0 | nM | 456.55 | N#Cc1cc(-c2ccnc(Nc3ccc(C4CCNCC4)nn3)c2)ccc1OC1CCOCC1 | Homo sapiens | CHEMBL3707546 | single protein format |
| CHEMBL4435393 |  |
IC50 | = | 6.0 | nM | 552.61 | C[C@H](c1ccnc(Nc2nc3ccc(-c4cnn(CC5CC5)c4)cc3[nH]2)c1)N1CCN(C(=O)CC(F)(F)F)CC1 | Homo sapiens | CHEMBL4380519 | assay format |