Q14123 | PDE1C_HUMAN | Dual specificity Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C (PDE1C)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00233 | PDEase_I - 3'5'-cyclic nucleotide phosphodiesterase | 227~455 | |
| PF08499 | PDEase_I_N - 3'5'-cyclic nucleotide phosphodiesterase N-terminal | 82~142 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL4639341 |  |
IC50 | = | 0.9 | nM | 421.93 | CC(C)n1ncc2c(=O)n(Cc3ccccc3)c(N[C@H](C)c3ccc(Cl)cc3)nc21 | Homo sapiens | CHEMBL4613136 | single protein format |
| CHEMBL4640793 |  |
IC50 | = | 1.5 | nM | 435.96 | C[C@@H](Nc1nc2c(cnn2C(C)(C)C)c(=O)n1Cc1ccccc1)c1ccc(Cl)cc1 | Homo sapiens | CHEMBL4613136 | single protein format |
| CHEMBL572934 |  |
IC50 | = | 2.1 | nM | 294.36 | O=c1[nH]c(Cc2ccccc2)nc2c1cnn2C1CCCC1 | Homo sapiens | CHEMBL1047622 | cell-based format |
| CHEMBL4647278 |  |
IC50 | = | 2.6 | nM | 419.5 | C[C@@H](Nc1nc2c(cnn2C(C)(C)C)c(=O)n1Cc1ccccc1)c1ccc(F)cc1 | Homo sapiens | CHEMBL4613136 | single protein format |
| CHEMBL4644729 |  |
IC50 | = | 2.9 | nM | 453.95 | C[C@@H](Nc1nc2c(cnn2C(C)(C)C)c(=O)n1Cc1ccc(F)cc1)c1ccc(Cl)cc1 | Homo sapiens | CHEMBL4613136 | single protein format |
| CHEMBL512790 |  |
IC50 | = | 4.0 | nM | 302.76 | CC(C)c1n[nH]c2c(=O)[nH]c(Cc3cccc(Cl)c3)nc12 | Homo sapiens | CHEMBL966926 | single protein format |
| CHEMBL4649493 |  |
IC50 | = | 4.7 | nM | 447.97 | C[C@@H](Nc1nc2c(cnn2C2CCCC2)c(=O)n1Cc1ccccc1)c1ccc(Cl)cc1 | Homo sapiens | CHEMBL4613136 | single protein format |
| CHEMBL3601563 |  |
IC50 | = | 7.0 | nM | 339.82 | COc1ccc2c([C@H]3CCc4ccc(Cl)cc43)nccc2c1OC | Homo sapiens | CHEMBL3602932 | single protein format |
| CHEMBL5180169 |  |
IC50 | = | 10.0 | nM | 535.64 | CC1=C(C(=O)O[C@H](C)c2ccccc2)C(c2ccc3c(cnn3C)c2)C(C(=O)O[C@H](C)c2ccccc2)=C(C)N1 | Homo sapiens | CHEMBL5168608 | assay format |
| CHEMBL2179093 |  |
IC50 | = | 14.0 | nM | 310.36 | O=c1[nH]c(Cc2ccccc2)nc2c1cnn2C1CCOCC1 | Homo sapiens | CHEMBL2185812 | cell-based format |
| CHEMBL5418520 |  |
IC50 | = | 15.0 | nM | 470.58 | Cc1ccc(-c2c(C#N)c(=O)n(Cc3ccccc3)c3cc(NC(C)c4ccccn4)ccc23)cc1 | Homo sapiens | CHEMBL5323837 | single protein format |
| CHEMBL5395569 |  |
IC50 | = | 15.0 | nM | 444.55 | N#Cc1c(C2CCCC2)c2ccc(NCc3ccc(F)cn3)cc2n(CC2CCCC2)c1=O | Homo sapiens | CHEMBL5323837 | single protein format |
| CHEMBL5419839 |  |
IC50 | = | 16.0 | nM | 440.59 | C[C@H](Nc1ccc2c(C3CCCC3)c(C#N)c(=O)n(CC3CCCC3)c2c1)c1ccccn1 | Homo sapiens | CHEMBL5323837 | single protein format |
| CHEMBL5396782 |  |
IC50 | = | 19.0 | nM | 440.59 | CC(Nc1ccc2c(C3CCCC3)c(C#N)c(=O)n(CC3CCCC3)c2c1)c1ccccn1 | Homo sapiens | CHEMBL5323837 | single protein format |
| CHEMBL4639286 |  |
IC50 | = | 20.0 | nM | 465.94 | CC(C)n1ncc2c(=O)n(Cc3ccc4c(c3)OCO4)c(N[C@H](C)c3ccc(Cl)cc3)nc21 | Homo sapiens | CHEMBL4613136 | single protein format |
| CHEMBL5396854 |  |
IC50 | = | 20.0 | nM | 448.57 | CC(Nc1ccc2c(C3CCCC3)c(C#N)c(=O)n(Cc3ccccc3)c2c1)c1ccccn1 | Homo sapiens | CHEMBL5323837 | single protein format |
| CHEMBL5411664 |  |
IC50 | = | 22.0 | nM | 422.53 | CC(C)c1c(C#N)c(=O)n(Cc2ccccc2)c2cc(NC(C)c3ccccn3)ccc12 | Homo sapiens | CHEMBL5323837 | single protein format |
| CHEMBL5415102 |  |
IC50 | = | 24.0 | nM | 470.58 | Cc1ccc(-c2c(C#N)c(=O)n(Cc3ccccc3)c3ccc(NC(C)c4ccccn4)cc23)cc1 | Homo sapiens | CHEMBL5323837 | single protein format |
| CHEMBL5413182 |  |
IC50 | = | 25.0 | nM | 462.6 | Cc1ccc(-c2c(C#N)c(=O)n(CC3CCCC3)c3cc(NC(C)c4ccccn4)ccc23)cc1 | Homo sapiens | CHEMBL5323837 | single protein format |
| CHEMBL4638381 |  |
IC50 | = | 27.0 | nM | 479.97 | C[C@@H](Nc1nc2c(cnn2C(C)(C)C)c(=O)n1Cc1ccc2c(c1)OCO2)c1ccc(Cl)cc1 | Homo sapiens | CHEMBL4613136 | single protein format |