Q13976 | KGP1_HUMAN | cGMP-dependent protein kinase 1 (PRKG1)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00027 | cNMP_binding - Cyclic nucleotide-binding domain | 122~203 | |
| PF00027 | cNMP_binding - Cyclic nucleotide-binding domain | 240~325 | |
| PF00069 | Pkinase - Protein kinase domain | 361~619 | |
| PF16808 | PKcGMP_CC - Coiled-coil N-terminus of cGMP-dependent protein kinase | 10~44 |
3D structures mapped by conservation among orthologs
[ Domain: "Double-stranded beta-helix" // cNMP_binding_1 ]
[ Domain: "Protein kinase" // Pkinase_Tyr ]
[ Domain: "Preprotein translocase SecE subunit" // DD_cGKI-beta ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL4448806 |  |
IC50 | = | 1.0 | nM | 332.4 | COc1cccc([C@@H](C)NC(=O)c2ccc(-c3ccncc3)cc2)c1 | Homo sapiens | CHEMBL4328711 | single protein format |
| CHEMBL388978 |  |
IC50 | = | 5.0 | nM | 466.54 | CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 | Homo sapiens | CHEMBL3807899 | single protein format |
| CHEMBL5433617 |  |
IC50 | = | 11.0 | nM | 299.36 | Cn1cncc1C1=CN(c2ncnc3[nH]cnc23)CCS1 | Homo sapiens | CHEMBL5373867 | single protein format |
| CHEMBL4459800 |  |
IC50 | = | 17.0 | nM | 350.39 | COc1cccc([C@@H](C)NC(=O)c2ccc(-c3ccnc(F)c3)cc2)c1 | Homo sapiens | CHEMBL5136861 | cell-based format |
| CHEMBL494089 |  |
IC50 | = | 33.0 | nM | 425.49 | CCn1c(-c2nonc2N)nc2c(C#CC(C)(C)O)ncc(OC[C@H]3CCCNC3)c21 | Homo sapiens | CHEMBL1028110 | single protein format |
| CHEMBL5181094 |  |
IC50 | = | 39.0 | nM | 333.39 | COc1cccc([C@@H](C)NC(=O)c2ccc(-c3ccncc3)nc2)c1 | Homo sapiens | CHEMBL5136861 | cell-based format |
| CHEMBL2177390 |  |
IC50 | = | 98.0 | nM | 458.01 | CC(C)NC[C@@H](C(=O)N1CCN(c2ncnc3c2[C@H](C)C[C@H]3O)CC1)c1ccc(Cl)cc1 | Homo sapiens | CHEMBL2187609 | single protein format |
| CHEMBL5176687 |  |
IC50 | = | 320.0 | nM | 351.38 | COc1cccc([C@@H](C)NC(=O)c2ccc(-c3ccnc(F)c3)nc2)c1 | Homo sapiens | CHEMBL5136861 | cell-based format |
| CHEMBL4438748 |  |
IC50 | = | 517.0 | nM | 457.49 | CN(C)c1ccc(C(=O)Nc2cccc(NC(=O)COc3ccc4c(=O)ccoc4c3)c2)cc1 | Homo sapiens | CHEMBL4379080 | single protein format |