Q13946 | PDE7A_HUMAN | High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A (PDE7A)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00233 | PDEase_I - 3'5'-cyclic nucleotide phosphodiesterase | 211~438 |
3D structures mapped by conservation among orthologs
[ Domain: "HD-domain/PDEase-like" // PDEase_I ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL3360172 |  |
IC50 | = | 0.32 | nM | 466.54 | CCn1c(Nc2ccncc2F)nc2c(C3CCCN(C(=O)C4(C#N)CC4)C3)csc2c1=O | Homo sapiens | CHEMBL3374135 | single protein format |
| CHEMBL3360170 |  |
IC50 | = | 0.68 | nM | 431.49 | CCn1c(Nc2ccncc2F)nc2c(C3CCCN(C(=O)OC)C3)csc2c1=O | Homo sapiens | CHEMBL3374135 | single protein format |
| CHEMBL3354181 |  |
IC50 | = | 1.0 | nM | 425.56 | CCn1c(NC2CCCC2)nc2c(-c3ccc(N4CCOCC4)nc3)csc2c1=O | Homo sapiens | CHEMBL3375790 | cell-based format |
| CHEMBL3360169 |  |
IC50 | = | 1.1 | nM | 431.49 | CCn1c(Nc2ccncc2F)nc2c(C3CCN(C(=O)OC)CC3)csc2c1=O | Homo sapiens | CHEMBL3374135 | single protein format |
| CHEMBL3360171 |  |
IC50 | = | 1.2 | nM | 473.57 | CCn1c(Nc2ccncc2F)nc2c(C3CCCN(C(=O)C(C)(C)CO)C3)csc2c1=O | Homo sapiens | CHEMBL3374135 | single protein format |
| CHEMBL3924897 |  |
IC50 | = | 1.3 | nM | 353.45 | COc1cc(N)ccc1-c1cc2c(c(=O)[nH]1)C(C1CCCCC1)N=[N+]2C | Homo sapiens | CHEMBL3706326 | single protein format |
| CHEMBL2019020 |  |
IC50 | = | 1.3 | nM | 353.43 | COc1cc(N)ccc1-c1nc2c(c(C3CCCCC3)nn2C)c(=O)[nH]1 | Homo sapiens | CHEMBL2019815 | single protein format |
| CHEMBL3403373 |  |
IC50 | = | 1.4 | nM | 425.56 | CCn1c(NC(C)C)nc2c(C3CCN(C(=O)c4ncccc4C)C3)csc2c1=O | Homo sapiens | CHEMBL3404605 | cell-based format |
| CHEMBL3403371 |  |
IC50 | = | 1.5 | nM | 410.54 | CCn1c(NC(C)C)nc2c(C3CCN(C(=O)c4ccccc4)C3)csc2c1=O | Homo sapiens | CHEMBL3404605 | cell-based format |
| CHEMBL3650287 |  |
IC50 | = | 2.0 | nM | 424.53 | Cc1nn(C2CCCCC2)c2sc(C(=O)Nc3ccc(N4CCNC4=O)nc3)cc12 | Homo sapiens | CHEMBL3706063 | cell-based format |
| CHEMBL3354179 |  |
IC50 | = | 2.0 | nM | 340.45 | CCn1c(NC2CCCC2)nc2c(-c3cccnc3)csc2c1=O | Homo sapiens | CHEMBL3374135 | single protein format |
| CHEMBL3360167 |  |
IC50 | = | 2.1 | nM | 348.4 | CCn1c(Nc2ccncc2F)nc2c(C(C)(C)O)csc2c1=O | Homo sapiens | CHEMBL3374135 | single protein format |
| CHEMBL3354180 |  |
IC50 | = | 2.3 | nM | 438.6 | CCn1c(NC2CCCC2)nc2c(-c3ccc(CN4CCOCC4)cc3)csc2c1=O | Homo sapiens | CHEMBL3375790 | cell-based format |
| CHEMBL3403372 |  |
IC50 | = | 2.7 | nM | 411.53 | CCn1c(NC(C)C)nc2c(C3CCN(C(=O)c4ccccn4)C3)csc2c1=O | Homo sapiens | CHEMBL3404605 | cell-based format |
| CHEMBL2171440 |  |
IC50 | = | 3.0 | nM | 421.5 | COc1cc(C2CC2C(N)=O)ccc1-c1nc2c(C)nn(C3CCCCC3)c(=O)c2[nH]1 | Homo sapiens | CHEMBL2174779 | single protein format |
| CHEMBL3650254 |  |
IC50 | = | 3.1 | nM | 457.69 | CNC1CCN([C@H]2CC[C@H](NC(=O)c3cc4c(C)nn(C5CCCCC5)c4s3)CC2)CC1 | Homo sapiens | CHEMBL3706063 | cell-based format |
| CHEMBL3403346 |  |
IC50 | = | 3.3 | nM | 425.56 | CCn1c(NC(C)C)nc2c(C3CCN(C(=O)c4cccc(C)n4)C3)csc2c1=O | Homo sapiens | CHEMBL3404605 | cell-based format |
| CHEMBL182536 |  |
IC50 | = | 3.5 | nM | 364.79 | O=C1Nc2c(Cl)ccc(OCc3noc(O)n3)c2C2(CCCCC2)N1 | Homo sapiens | CHEMBL828160 | cell-based format |
| CHEMBL3650259 |  |
IC50 | = | 3.5 | nM | 471.67 | CC(=O)N1CCN([C@H]2CC[C@H](NC(=O)c3cc4c(C)nn(C5CCCCC5)c4s3)CC2)CC1 | Homo sapiens | CHEMBL3706063 | cell-based format |
| CHEMBL186868 |  |
IC50 | = | 3.9 | nM | 354.48 | Cc1nc(N)c2ccc(-c3nn(C)/c(=N/C4CCCCC4)s3)cc2n1 | Homo sapiens | CHEMBL828296 | cell-based format |