Q13936 | CAC1C_HUMAN | Voltage-dependent L-type calcium channel subunit alpha-1C (CACNA1C)

Pfam Domain Table

AccessionDomainRangeColor
PF00520Ion_trans - Ion transport protein124~415
PF00520Ion_trans - Ion transport protein524~761
PF00520Ion_trans - Ion transport protein952~1196
PF00520Ion_trans - Ion transport protein1239~1321
PF00520Ion_trans - Ion transport protein1324~1534
PF08763Ca_chan_IQ - Voltage gated calcium channel IQ domain1607~1681
PF16885CAC1F_C - Voltage-gated calcium channel subunit alpha, C-term2097~2171
PF16905GPHH - Voltage-dependent L-type calcium channel, IQ-associated1544~1597

3D structures mapped by conservation among orthologs

[ Domain: "Voltage gated calcium channel IQ domain" // Ca_chan_IQ ]

 PyMOL session

[ Domain: "Voltage gated calcium channel IQ domain" // UNK_F_TYPE ]

 PyMOL session


[ Alpha Fold Model ] (go)



Known binders annotated in ChEMBL

 IC50 CSV    Ki CSV
Only the first 20 rows are shown.
molecule_chembl_idstructureassay_typerelation valueunitmol_wtsmilesorganism assay_chembl_idbao_label
CHEMBL3392230 IC50 = 100.0 nM 409.49 CCOC(=O)C1=C(C)NC(C)=C(C#N)[C@@H]1c1cnccc1-c1ccc2ccccc2c1 Homo sapiens CHEMBL660543 single protein format
CHEMBL3608946 IC50 = 140.0 nM 457.62 CN(CCCc1nc2ccccc2[nH]1)CC[C@@]1(OC(=O)C2CC2)C[C@@H]2CC[C@H]1c1ccccc12 Homo sapiens CHEMBL3611367 cell-based format
CHEMBL6966 IC50 = 150.0 nM 454.61 COc1ccc(CCN(C)CCCC(C#N)(c2ccc(OC)c(OC)c2)C(C)C)cc1OC Homo sapiens CHEMBL656260 cell membrane format
CHEMBL3608941 IC50 = 156.0 nM 599.79 CC(C)C(=O)O[C@]1(CCN(C)CCCc2nc3ccccc3[nH]2)C[C@@H](OCc2ccccc2)c2cc(F)ccc2[C@@H]1C(C)C Homo sapiens CHEMBL3611367 cell-based format
CHEMBL3609824 IC50 = 173.0 nM 551.75 CCCC[C@@H]1C[C@@](CCN(C)CCCc2nc3ccccc3[nH]2)(OC(=O)COC)[C@@H](C(C)C)c2ccc(F)cc21 Homo sapiens CHEMBL3611367 cell-based format
CHEMBL45816 IC50 = 202.0 nM 495.64 COCC(=O)O[C@]1(CCN(C)CCCc2nc3ccccc3[nH]2)CCc2cc(F)ccc2[C@@H]1C(C)C Homo sapiens CHEMBL3611367 cell-based format
CHEMBL3608316 IC50 = 225.0 nM 599.79 CC(C)C(=O)O[C@]1(CCN(C)CCCc2nc3ccccc3[nH]2)C[C@H](OCc2ccccc2)c2cc(F)ccc2[C@@H]1C(C)C Homo sapiens CHEMBL3611367 cell-based format
CHEMBL3392227 IC50 = 250.0 nM 359.43 CCOC(=O)C1=C(C)NC(C)=C(C#N)[C@@H]1c1cnccc1-c1ccccc1 Homo sapiens CHEMBL660543 single protein format
CHEMBL3392229 IC50 = 270.0 nM 409.49 CCOC(=O)C1=C(C)NC(C)=C(C#N)[C@@H]1c1cnccc1-c1cccc2ccccc12 Homo sapiens CHEMBL660543 single protein format
CHEMBL3609822 IC50 = 347.0 nM 493.67 CC(C)C(=O)O[C@]1(CCN(C)CCCc2nc3ccccc3[nH]2)CCc2cc(F)ccc2[C@@H]1C(C)C Homo sapiens CHEMBL3611367 cell-based format
CHEMBL3609819 IC50 = 387.0 nM 503.69 COc1cccc2nc(CCCN(C)CC[C@]3(OC(=O)C(C)C)C[C@H]4CCC[C@@H]3c3ccccc34)[nH]c12 Homo sapiens CHEMBL3611367 cell-based format
CHEMBL138302 IC50 = 390.0 nM 494.68 COc1ccc(CCN(C)C2CCCC(C(C#N)(c3ccc(OC)c(OC)c3)C(C)C)C2)cc1OC Homo sapiens CHEMBL656260 cell membrane format
CHEMBL3608940 IC50 = 403.0 nM 523.69 CO[C@H]1C[C@@](CCN(C)CCCc2nc3ccccc3[nH]2)(OC(=O)C(C)C)[C@@H](C(C)C)c2ccc(F)cc21 Homo sapiens CHEMBL3611367 cell-based format
CHEMBL3609817 IC50 = 424.0 nM 459.63 CC(C)C(=O)O[C@@]1(CCN(C)CCCc2nc3ccccc3[nH]2)C[C@H]2CC[C@@H]1c1ccccc12 Homo sapiens CHEMBL3611367 cell-based format
CHEMBL3608943 IC50 = 426.0 nM 509.67 CC(C)C(=O)O[C@]1(CCN(C)CCCc2nc3ccccc3[nH]2)C[C@H](O)c2cc(F)ccc2[C@@H]1C(C)C Homo sapiens CHEMBL3611367 cell-based format
CHEMBL3609823 IC50 = 434.0 nM 523.69 COCC(=O)O[C@]1(CCN(C)CCCc2nc3ccccc3[nH]2)CC(C)(C)c2cc(F)ccc2[C@@H]1C(C)C Homo sapiens CHEMBL3611367 cell-based format
CHEMBL3609818 IC50 = 455.0 nM 473.66 CC(C)C(=O)O[C@@]1(CCN(C)CCCc2nc3ccccc3[nH]2)C[C@H]2CCC[C@@H]1c1ccccc12 Homo sapiens CHEMBL3611367 cell-based format
CHEMBL3608942 IC50 = 504.0 nM 509.67 CC(C)C(=O)O[C@]1(CCN(C)CCCc2nc3ccccc3[nH]2)C[C@@H](O)c2cc(F)ccc2[C@@H]1C(C)C Homo sapiens CHEMBL3611367 cell-based format
CHEMBL343771 IC50 = 540.0 nM 480.65 COc1ccc(CCNC2CCCC(C(C#N)(c3ccc(OC)c(OC)c3)C(C)C)C2)cc1OC Homo sapiens CHEMBL656260 cell membrane format
CHEMBL3609825 IC50 = 588.0 nM 523.69 CO[C@@H]1C[C@@](CCN(C)CCCc2nc3ccccc3[nH]2)(OC(=O)C(C)C)[C@@H](C(C)C)c2ccc(F)cc21 Homo sapiens CHEMBL3611367 cell-based format