Q13882 | PTK6_HUMAN | Protein-tyrosine kinase 6 (PTK6)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00017 | SH2 - SH2 domain | 78~155 | |
| PF00018 | SH3_1 - SH3 domain | 16~63 | |
| PF07714 | PK_Tyr_Ser-Thr - Protein tyrosine and serine/threonine kinase | 192~441 |
3D structures mapped by conservation among orthologs
[ Domain: "SH3" // SH3_1 ]
[ Domain: "SH2" // SH2 ]
[ Domain: "Protein kinase" // Pkinase_Tyr ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL1836842 |  |
IC50 | = | 2.0 | nM | 491.0 | CC1(C)CNCCN1C(=O)c1ccc(Nc2nc(C3CC3)cn3c(-c4cn[nH]c4)cnc23)cc1Cl | Homo sapiens | CHEMBL1839617 | single protein format |
| CHEMBL5280844 |  |
IC50 | = | 2.5 | nM | 478.94 | O=C(c1ccc(Oc2ccccc2)cc1Cl)c1c[nH]c2ncnc(NC3CC[C@@H](CO)OC3)c12 | Homo sapiens | CHEMBL5242631 | single protein format |
| CHEMBL1836806 |  |
IC50 | = | 3.0 | nM | 450.89 | Cc1cn2c(-c3cn[nH]c3)cnc2c(Nc2ccc(C(=O)N3CCNC(=O)C3)c(Cl)c2)n1 | Homo sapiens | CHEMBL1839617 | single protein format |
| CHEMBL1836844 |  |
IC50 | = | 3.0 | nM | 491.0 | CC1(C)CN(C(=O)c2ccc(Nc3nc(C4CC4)cn4c(-c5cn[nH]c5)cnc34)cc2Cl)CCN1 | Homo sapiens | CHEMBL1839617 | single protein format |
| CHEMBL1836854 |  |
IC50 | = | 3.0 | nM | 446.49 | O=C(c1ccc(Nc2nc(C3CC3)cn3c(-c4cn[nH]c4)cnc23)c(F)c1)N1CCNCC1 | Homo sapiens | CHEMBL1839617 | single protein format |
| CHEMBL1836863 |  |
IC50 | = | 3.0 | nM | 474.54 | CC1(C)CNCCN1C(=O)c1ccc(Nc2nc(C3CC3)cn3c(-c4cn[nH]c4)cnc23)c(F)c1 | Homo sapiens | CHEMBL1839617 | single protein format |
| CHEMBL3133821 |  |
IC50 | = | 3.2 | nM | 275.31 | Oc1cccc(Nc2ccnc3[nH]c4ccccc4c23)c1 | Homo sapiens | CHEMBL3134836 | cell-based format |
| CHEMBL1873475 |  |
IC50 | = | 3.3 | nM | 440.51 | C=CC(=O)N1CCC[C@@H](n2nc(-c3ccc(Oc4ccccc4)cc3)c3c(N)ncnc32)C1 | Homo sapiens | CHEMBL3887545 | single protein format |
| CHEMBL3647967 |  |
IC50 | = | 3.3 | nM | 454.53 | C=CC(=O)N[C@H]1CC[C@@H](n2nc(-c3ccc(Oc4ccccc4)cc3)c3c(N)ncnc32)CC1 | Homo sapiens | CHEMBL3887545 | single protein format |
| CHEMBL3133815 |  |
IC50 | = | 4.1 | nM | 383.2 | O=[N+]([O-])c1cccc(Nc2ccnc3[nH]c4ccc(Br)cc4c23)c1 | Homo sapiens | CHEMBL3134836 | cell-based format |
| CHEMBL3238103 |  |
IC50 | = | 4.41 | nM | 368.23 | COc1cc(Nc2ccnc3[nH]c4ccccc4c23)ccc1Br | Homo sapiens | CHEMBL3241182 | single protein format |
| CHEMBL3133822 |  |
IC50 | = | 4.7 | nM | 293.76 | Clc1cccc(Nc2ccnc3[nH]c4ccccc4c23)c1 | Homo sapiens | CHEMBL3134836 | cell-based format |
| CHEMBL3133828 |  |
IC50 | = | 4.8 | nM | 437.53 | COc1cccc(Nc2ccnc3[nH]c4ccc(S(=O)(=O)N5CCNCC5)cc4c23)c1 | Homo sapiens | CHEMBL3134836 | cell-based format |
| CHEMBL1836846 |  |
IC50 | = | 5.0 | nM | 488.98 | O=C(c1ccc(Nc2nc(C3CC3)cn3c(-c4cn[nH]c4)cnc23)cc1Cl)N1C[C@H]2CC[C@@H]1CN2 | Homo sapiens | CHEMBL1839617 | single protein format |
| CHEMBL3238097 |  |
IC50 | = | 5.65 | nM | 304.31 | O=[N+]([O-])c1cccc(Nc2ccnc3[nH]c4ccccc4c23)c1 | Homo sapiens | CHEMBL3241182 | single protein format |
| CHEMBL3133825 |  |
IC50 | = | 5.7 | nM | 438.51 | COc1cccc(Nc2ccnc3[nH]c4ccc(S(=O)(=O)N5CCOCC5)cc4c23)c1 | Homo sapiens | CHEMBL3134836 | cell-based format |
| CHEMBL1836755 |  |
IC50 | = | 6.0 | nM | 462.95 | O=C(c1ccc(Nc2nc(C3CC3)cn3c(-c4cn[nH]c4)cnc23)cc1Cl)N1CCNCC1 | Homo sapiens | CHEMBL1839617 | single protein format |
| CHEMBL1836865 |  |
IC50 | = | 6.0 | nM | 474.54 | CC1(C)CN(C(=O)c2ccc(Nc3nc(C4CC4)cn4c(-c5cn[nH]c5)cnc34)c(F)c2)CCN1 | Homo sapiens | CHEMBL1839617 | single protein format |
| CHEMBL1836867 |  |
IC50 | = | 7.0 | nM | 436.91 | Cc1cn2c(-c3cn[nH]c3)cnc2c(Nc2ccc(C(=O)N3CCNCC3)c(Cl)c2)n1 | Homo sapiens | CHEMBL1839617 | single protein format |
| CHEMBL1836840 |  |
IC50 | = | 7.0 | nM | 462.95 | Cc1cn2c(-c3cn[nH]c3)cnc2c(Nc2ccc(C(=O)N3C[C@H]4CC[C@@H]3CN4)c(Cl)c2)n1 | Homo sapiens | CHEMBL1839617 | single protein format |