Q13698 | CAC1S_HUMAN | Voltage-dependent L-type calcium channel subunit alpha-1S (CACNA1S)
Helixβ‑strandTurn secondary structure
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00520 | Ion_trans | 51–344 | |
| PF00520 | Ion_trans | 432–669 | |
| PF00520 | Ion_trans | 799–1074 | |
| PF00520 | Ion_trans | 1118–1391 | |
| PF08763 | Ca_chan_IQ | 1464–1536 | |
| PF16905 | GPHH | 1401–1454 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL319525 |  |
Ki | = | 42.0 | nM | 444.55 | COc1ccc([C@@H]2Sc3cc(OC)ccc3N(CCN(C)C)C(=O)[C@@H]2OC(C)=O)cc1 | Homo sapiens | CHEMBL660031 | tissue-based format |
| CHEMBL96454 |  |
Ki | = | 85.0 | nM | 400.54 | COc1ccc([C@@H]2Sc3cc(OC)ccc3N(CCN(C)C)C(=O)[C@@H]2C)cc1 | Homo sapiens | CHEMBL660031 | tissue-based format |
| CHEMBL23 |  |
Ki | = | 380.0 | nM | 414.53 | COc1ccc([C@@H]2Sc3ccccc3N(CCN(C)C)C(=O)[C@@H]2OC(C)=O)cc1 | Homo sapiens | CHEMBL660031 | tissue-based format |
| CHEMBL262509 |  |
Ki | = | 540.0 | nM | 370.52 | COc1ccc([C@@H]2Sc3ccccc3N(CCN(C)C)C(=O)[C@@H]2C)cc1 | Homo sapiens | CHEMBL660031 | tissue-based format |
| CHEMBL98189 |  |
Ki | = | 650.0 | nM | 352.48 | COc1ccc([C@@H]2Cc3ccccc3N(CCN(C)C)C(=O)[C@@H]2C)cc1 | Homo sapiens | CHEMBL660031 | tissue-based format |