Q13639 | 5HT4R_HUMAN | 5-hydroxytryptamine receptor 4 (HTR4)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00001 | 7tm_1 - 7 transmembrane receptor (rhodopsin family) | 36~312 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL3901228 |  |
IC50 | = | 0.002 | nM | 426.95 | COc1cc(N)c(Cl)cc1C(=O)NCC1CCNC(Cc2c[nH]c3ccccc23)C1 | Homo sapiens | CHEMBL3887753 | cell-based format |
| CHEMBL3922150 |  |
IC50 | = | 0.005 | nM | 483.06 | COc1cc(N)c(Cl)cc1C(=O)NCC1CCN(CCCCCn2ccc3ccccc32)CC1 | Homo sapiens | CHEMBL3887753 | cell-based format |
| CHEMBL3967117 |  |
IC50 | = | 0.039 | nM | 455.0 | COc1cc(N)c(Cl)cc1C(=O)NCC1CCN(CCCn2ccc3ccccc32)CC1 | Homo sapiens | CHEMBL3887753 | cell-based format |
| CHEMBL3950712 |  |
IC50 | = | 0.067 | nM | 406.92 | COc1cc(N)c(Cl)cc1C(=O)NCC1CCN(CCCn2ccnn2)CC1 | Homo sapiens | CHEMBL3887753 | cell-based format |
| CHEMBL3934371 |  |
IC50 | = | 0.076 | nM | 440.98 | COc1cc(N)c(Cl)cc1C(=O)NCC1CCN(Cc2cn(C)c3ccccc23)CC1 | Homo sapiens | CHEMBL3887753 | cell-based format |
| CHEMBL3926377 |  |
IC50 | = | 0.103 | nM | 434.97 | COc1cc(N)c(Cl)cc1C(=O)NCC1CCN(CCCCCn2ccnn2)CC1 | Homo sapiens | CHEMBL3887753 | cell-based format |
| CHEMBL3890747 |  |
IC50 | = | 0.134 | nM | 405.9 | COc1cc(N)c(Cl)cc1C(=O)NCC1CCN(Cc2ccc(F)cc2)CC1 | Homo sapiens | CHEMBL3887753 | cell-based format |
| CHEMBL3986866 |  |
IC50 | = | 0.164 | nM | 407.91 | COc1cc(N)c(Cl)cc1C(=O)NCC1CCN(CCCn2cnnn2)CC1 | Homo sapiens | CHEMBL3887753 | cell-based format |
| CHEMBL3957180 |  |
IC50 | = | 0.182 | nM | 406.92 | COc1cc(N)c(Cl)cc1C(=O)NCC1CCN(CCCn2nccn2)CC1 | Homo sapiens | CHEMBL3887753 | cell-based format |
| CHEMBL3946162 |  |
IC50 | = | 0.226 | nM | 406.92 | COc1cc(N)c(Cl)cc1C(=O)NCC1CCN(CCCn2cncn2)CC1 | Homo sapiens | CHEMBL3887753 | cell-based format |
| CHEMBL3928124 |  |
IC50 | = | 0.229 | nM | 419.96 | COc1cc(N)c(Cl)cc1C(=O)NCC1CCN(CCCn2ccnc2C)CC1 | Homo sapiens | CHEMBL3887753 | cell-based format |
| CHEMBL3982522 |  |
IC50 | = | 0.267 | nM | 388.9 | COc1cc(N)c(Cl)cc1C(=O)NCC1CCN(Cc2cccnc2)CC1 | Homo sapiens | CHEMBL3887753 | cell-based format |
| CHEMBL1729 |  |
IC50 | = | 0.362 | nM | 465.95 | COc1cc(N)c(Cl)cc1C(=O)NC1CCN(CCCOc2ccc(F)cc2)CC1OC | Homo sapiens | CHEMBL3887753 | cell-based format |
| CHEMBL3920018 |  |
IC50 | = | 0.375 | nM | 403.91 | COc1cc(N)c(Cl)cc1C(=O)NCC1CCN(Cc2ccc(O)cc2)CC1 | Homo sapiens | CHEMBL3887753 | cell-based format |
| CHEMBL3915236 |  |
IC50 | = | 0.421 | nM | 390.92 | COc1cc(N)c(Cl)cc1C(=O)NCC1CCN(Cc2cccn2C)CC1 | Homo sapiens | CHEMBL3887753 | cell-based format |
| CHEMBL3910849 |  |
IC50 | = | 0.454 | nM | 377.88 | COc1cc(N)c(Cl)cc1C(=O)NCC1CCN(Cc2ncc[nH]2)CC1 | Homo sapiens | CHEMBL3887753 | cell-based format |
| CHEMBL3220223 |  |
IC50 | = | 1.4 | nM | 467.96 | COc1cc(N)c(Cl)cc1C(=O)OCCN1CCN(c2ccccc2-c2cnccn2)CC1 | Homo sapiens | CHEMBL3222890 | single protein format |
| CHEMBL334325 |  |
IC50 | = | 3.0 | nM | 419.91 | COc1cccc(N2CCN(CCOC(=O)c3cc(Cl)c(N)cc3OC)CC2)c1 | Homo sapiens | CHEMBL3222890 | single protein format |
| CHEMBL4526049 |  |
IC50 | = | 7.5 | nM | 418.92 | COc1cc(N)c(Cl)cc1C(=O)CCC1CCN(Cc2ccc(O)c(O)c2)CC1 | Homo sapiens | CHEMBL4362792 | assay format |
| CHEMBL4451349 |  |
IC50 | < | 10.0 | nM | 348.88 | CCCCN1CCC(CNC(=O)c2cc(Cl)cn3ccnc23)CC1 | Homo sapiens | CHEMBL4415156 | single protein format |