Q13627 | DYR1A_HUMAN | Dual specificity tyrosine-phosphorylation-regulated kinase 1A (DYRK1A)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00069 | Pkinase - Protein kinase domain | 159~479 |
3D structures mapped by conservation among orthologs
[ Domain: "Protein kinase" // Pkinase_Tyr ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL5438158 |  |
IC50 | = | 0.0 | nM | 396.49 | O=C1NC(NC23CC4CC(CC(F)(C4)C2)C3)=N/C1=C\c1ccc2ncsc2c1 | Homo sapiens | CHEMBL5363958 | single protein format |
| CHEMBL5417147 |  |
IC50 | = | 0.0 | nM | 408.53 | COC12CC3CC(CC(NC4=N/C(=C\c5ccc6ncsc6c5)C(=O)N4)(C3)C1)C2 | Homo sapiens | CHEMBL5363958 | single protein format |
| CHEMBL5405059 |  |
IC50 | = | 0.0 | nM | 394.5 | O=C1NC(NC23CC4CC(CC(O)(C4)C2)C3)=N/C1=C\c1ccc2ncsc2c1 | Homo sapiens | CHEMBL5363958 | single protein format |
| CHEMBL5404544 |  |
IC50 | = | 0.0 | nM | 364.43 | O=C1NC(N[C@@H](CO)c2ccccc2)=N/C1=C\c1ccc2ncsc2c1 | Homo sapiens | CHEMBL5363958 | single protein format |
| CHEMBL2386744 |  |
IC50 | = | 0.16 | nM | 432.28 | COC(=N)c1nc2ccc3ncnc(Nc4ccc(Br)cc4F)c3c2s1 | Homo sapiens | CHEMBL2388921 | single protein format |
| CHEMBL2386747 |  |
IC50 | = | 0.22 | nM | 404.28 | COC(=N)c1nc2ccc3ncnc(Nc4ccc(Cl)cc4Cl)c3c2s1 | Homo sapiens | CHEMBL2388921 | single protein format |
| CHEMBL3894571 |  |
IC50 | = | 0.36 | nM | 383.41 | COC(=N)c1nc2ccc3ncnc(Nc4ccc(OC)cc4F)c3c2s1 | Homo sapiens | CHEMBL3889022 | single protein format |
| CHEMBL2386745 |  |
IC50 | = | 0.36 | nM | 383.41 | COC(=N)c1nc2ccc3ncnc(Nc4ccc(F)cc4OC)c3c2s1 | Homo sapiens | CHEMBL2388921 | single protein format |
| CHEMBL2386748 |  |
IC50 | = | 0.94 | nM | 371.37 | COC(=N)c1nc2ccc3ncnc(Nc4ccc(F)cc4F)c3c2s1 | Homo sapiens | CHEMBL2388921 | single protein format |
| CHEMBL2386764 |  |
IC50 | = | 0.98 | nM | 349.42 | COC(=N)c1nc2ccc3ncnc(Nc4ccc(C)cc4)c3c2s1 | Homo sapiens | CHEMBL2388921 | single protein format |
| CHEMBL2386746 |  |
IC50 | = | 0.99 | nM | 387.83 | COC(=N)c1nc2ccc3ncnc(Nc4ccc(F)cc4Cl)c3c2s1 | Homo sapiens | CHEMBL2388921 | single protein format |
| CHEMBL3971170 |  |
IC50 | = | 0.99 | nM | 387.83 | COC(=N)c1nc2ccc3ncnc(Nc4ccc(Cl)cc4F)c3c2s1 | Homo sapiens | CHEMBL3889022 | single protein format |
| CHEMBL5400230 |  |
IC50 | = | 1.0 | nM | 364.47 | O=C1NC(NC23CC4CC(CC2C4)C3)=N/C1=C\c1ccc2ncsc2c1 | Homo sapiens | CHEMBL5363958 | single protein format |
| CHEMBL5428651 |  |
IC50 | = | 1.0 | nM | 394.5 | O=C1NC(N[C@H]2C3CC4CC2C[C@](O)(C4)C3)=N/C1=C\c1ccc2ncsc2c1 | Homo sapiens | CHEMBL5363958 | single protein format |
| CHEMBL5073869 |  |
IC50 | = | 1.0 | nM | 253.3 | Cc1oc2ccc(-c3cc(N)nc(N)c3)cc2c1C | Homo sapiens | CHEMBL5042806 | single protein format |
| CHEMBL5409574 |  |
IC50 | = | 1.0 | nM | 471.61 | CS(=O)(=O)NC12CC3CC(CC(NC4=N/C(=C\c5ccc6ncsc6c5)C(=O)N4)(C3)C1)C2 | Homo sapiens | CHEMBL5363958 | single protein format |
| CHEMBL5422486 |  |
IC50 | = | 1.0 | nM | 432.47 | O=C1NC(NC23CC4(F)CC(F)(CC(F)(C4)C2)C3)=N/C1=C\c1ccc2ncsc2c1 | Homo sapiens | CHEMBL5363958 | single protein format |
| CHEMBL5088511 |  |
IC50 | = | 1.0 | nM | 360.42 | Cc1nc2ccc(-c3cc(N)nc(N)c3)nc2n1CCOc1ccccc1 | Homo sapiens | CHEMBL5042806 | single protein format |
| CHEMBL5418722 |  |
IC50 | = | 1.0 | nM | 461.59 | O=C1NC(NC23CC4CC(CC(NC(=O)C5CC5)(C4)C2)C3)=N/C1=C\c1ccc2ncsc2c1 | Homo sapiens | CHEMBL5363958 | single protein format |
| CHEMBL5422654 |  |
IC50 | = | 1.0 | nM | 435.55 | CC(=O)NC12CC3CC(C1)CC(NC1=N/C(=C\c4ccc5ncsc5c4)C(=O)N1)(C3)C2 | Homo sapiens | CHEMBL5363958 | single protein format |