3D structures mapped by conservation among orthologs

[ Domain: "winged" // Cullin_Nedd8 ]

 PyMOL session

[ Domain: "winged" // Cullin_4th ]

 PyMOL session

[ Domain: "ARM repeat" // Cullin_1st ]

 PyMOL session

[ Domain: "ARM repeat" // Cullin_2nd ]

 PyMOL session

[ Domain: "a+b domain in cullin-like proteins" // Cullin_3rd ]

 PyMOL session

[ Alpha Fold Model ] (go)

Known binders annotated in ChEMBL

 IC50 CSV

Only the first 20 rows are shown.

molecule_chembl_id	structure	assay_type	relation	value	unit	mol_wt	smiles	organism	assay_chembl_id	bao_label
CHEMBL4539276		IC50	=	114.0	nM	282.37	N#Cc1c(-c2ccc(O)cc2)c2c([nH]c1=S)CCCC2	Homo sapiens	CHEMBL4418840	single protein format
CHEMBL4585473		IC50	=	140.0	nM	309.13	CCOC(=O)Oc1c(Cl)cc2oc(=O)sc2c1Cl	Homo sapiens	CHEMBL4418840	single protein format
CHEMBL4462527		IC50	=	191.0	nM	274.68	CCOC(=O)Oc1cc2oc(=O)sc2cc1Cl	Homo sapiens	CHEMBL4418840	single protein format
CHEMBL4444266		IC50	=	236.0	nM	260.65	COC(=O)Oc1cc2oc(=O)sc2cc1Cl	Homo sapiens	CHEMBL4418840	single protein format
CHEMBL406369		IC50	<	240.0	nM	398.03	COC(=O)Oc1c(Br)c(C)c2oc(=O)sc2c1Br	Homo sapiens	CHEMBL4418840	single protein format
CHEMBL3115927		IC50	<	240.0	nM	383.02	CNC(=O)Oc1c(Br)cc2sc(=O)oc2c1Br	Homo sapiens	CHEMBL4418840	single protein format
CHEMBL4451022		IC50	<	240.0	nM	288.2	CC(C)c1nnc(S)n1-c1ccc(Cl)c(Cl)c1	Homo sapiens	CHEMBL4418840	single protein format
CHEMBL4475993		IC50	=	464.0	nM	282.09	CC(=O)CN1C(=O)C(=O)c2cc(Br)ccc21	Homo sapiens	CHEMBL4418840	single protein format
CHEMBL1532407		IC50	=	554.0	nM	256.33	N#Cc1c(S)nc2c(c1-c1ccco1)CCCC2	Homo sapiens	CHEMBL4418840	single protein format
CHEMBL4592960		IC50	=	738.0	nM	296.4	COc1ccc(-c2c3c([nH]c(=S)c2C#N)CCCC3)cc1	Homo sapiens	CHEMBL4418840	single protein format
CHEMBL4442009		IC50	=	943.0	nM	240.05	Clc1ccc2nc(Cl)c3nnnn3c2c1	Homo sapiens	CHEMBL4418840	single protein format
CHEMBL1540912		IC50	=	997.0	nM	282.37	COc1ccc(-c2c(C#N)c(S)nc3c2CCC3)cc1	Homo sapiens	CHEMBL4418840	single protein format