Q13574 | DGKZ_HUMAN | Diacylglycerol kinase zeta (DGKZ)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00130 | C1_1 - Phorbol esters/diacylglycerol binding domain (C1 domain) | 172~230 | |
| PF00609 | DAGK_acc - Diacylglycerol kinase accessory domain | 446~603 | |
| PF00781 | DAGK_cat - Diacylglycerol kinase catalytic domain | 295~410 | |
| PF12796 | Ank_2 - Ankyrin repeats (3 copies) | 794~888 | |
| PF23578 | DGKI - Diacylglycerol kinase iota-like domain | 632~755 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL5424446 |  |
IC50 | = | 2.0 | nM | 516.51 | Cn1c(=O)c([N+](=O)[O-])c(N2CCN(C(c3ccc(F)cc3)c3ccc(F)cc3)CC2)c2nc(C#N)ccc21 | Homo sapiens | CHEMBL5363632 | single protein format |
| CHEMBL4648848 |  |
IC50 | = | 330.0 | nM | 499.57 | C[C@@H]1CN(c2cc(=O)n(C)c3ccc(C#N)nc23)[C@@H](C)CN1C(c1ccc(F)cc1)c1ccccc1F | Homo sapiens | CHEMBL4618781 | cell-based format |
| CHEMBL4645744 |  |
IC50 | = | 400.0 | nM | 499.57 | C[C@@H]1CN(c2cc(=O)n(C)c3ccc(C#N)nc23)[C@@H](C)CN1C(c1ccc(F)cc1)c1ccc(F)cc1 | Homo sapiens | CHEMBL4618781 | cell-based format |
| CHEMBL4633304 |  |
IC50 | = | 490.0 | nM | 509.01 | C[C@@H]1CN(c2c(C#N)c(=O)n(C)c3ccc(C#N)nc23)CCN1C(c1ccccc1)c1ccc(Cl)cc1 | Homo sapiens | CHEMBL4618781 | cell-based format |
| CHEMBL4647083 |  |
IC50 | = | 830.0 | nM | 543.46 | C[C@@H]1CN(c2c(C#N)c(=O)n(C)c3ccc(C#N)nc23)CCN1C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 | Homo sapiens | CHEMBL4618781 | cell-based format |