Q13535 | ATR_HUMAN | Serine/threonine-protein kinase ATR (ATR)

Pfam Domain Table

AccessionDomainRangeColor
PF00454PI3_PI4_kinase - Phosphatidylinositol 3- and 4-kinase2324~2566
PF02259FAT - FAT domain1772~2092
PF02260FATC - FATC domain2613~2644
PF08064UME - UME (NUC010) domain1122~1222
PF23593HEAT_ATR - Serine/threonine-protein kinase ATR-like, HEAT repeats2121~2219
PF25030M-HEAT_ATR - Serine/threonine-protein kinase ATR, M-HEAT region1482~1709
PF25032N-HEAT_ATR - Serine/threonine-protein kinase ATR, N-HEAT region5~551

3D structures mapped by conservation among orthologs


[ Alpha Fold Model ] (go)



Known binders annotated in ChEMBL

 IC50 CSV    Ki CSV
Only the first 20 rows are shown.
molecule_chembl_idstructureassay_typerelation valueunitmol_wtsmilesorganism assay_chembl_idbao_label
CHEMBL3355476 IC50 = 0.1 nM 366.4 C[C@@H]1COCCN1c1nc(-c2c(F)ncc3[nH]ccc23)cc2c1ncn2C Homo sapiens CHEMBL3372398 single protein format
CHEMBL3355474 IC50 = 0.2 nM 440.53 C[C@@H]1COCCN1c1nc(-c2cncc3[nH]ccc23)cc2c1ncn2[C@@H](C)S(C)(=O)=O Homo sapiens CHEMBL3372398 single protein format
CHEMBL3355072 IC50 = 0.3 nM 407.5 C[C@@H]1Cn2ncc(-c3ccc(S(C)(=O)=O)cc3)c2CN1c1ccnc2[nH]ccc12 Homo sapiens CHEMBL3379628 single protein format
CHEMBL3355074 IC50 = 0.4 nM 448.98 C[C@@H]1Cn2ncc(C3CCN(S(C)(=O)=O)CC3)c2CN1c1cc(Cl)nc2[nH]ccc12 Homo sapiens CHEMBL3379628 single protein format
CHEMBL3355475 IC50 = 0.4 nM 348.41 C[C@@H]1COCCN1c1nc(-c2cncc3[nH]ccc23)cc2c1ncn2C Homo sapiens CHEMBL3372398 single protein format
CHEMBL3355071 IC50 = 0.5 nM 436.54 C[C@@H]1Cn2ncc(-c3ccc(S(=O)(=O)N(C)C)cc3)c2CN1c1ccnc2[nH]ccc12 Homo sapiens CHEMBL3379628 single protein format
CHEMBL3355480 IC50 = 0.5 nM 349.4 C[C@@H]1COCCN1c1nc(-c2nncc3[nH]ccc23)cc2c1ncn2C Homo sapiens CHEMBL3372398 single protein format
CHEMBL3355069 IC50 = 0.5 nM 418.48 CN(C)S(=O)(=O)c1ccc(-c2cnc3ccc(-c4ccnc5[nH]ccc45)nn23)cc1 Homo sapiens CHEMBL3379628 single protein format
CHEMBL3355473 IC50 = 1.0 nM 425.51 C[C@@H]1COCCN1c1nc(-c2cccc3[nH]ccc23)cc2c1ncn2CS(C)(=O)=O Homo sapiens CHEMBL3372398 single protein format
CHEMBL4288033 IC50 = 1.0 nM 428.52 C[C@@H]1COCCN1c1cc(C2(S(C)(=O)=O)CC2)nc(-n2c(N)nc3ccccc32)n1 Homo sapiens CHEMBL4269677 single protein format
CHEMBL3355070 IC50 = 1.0 nM 422.51 CN(C)S(=O)(=O)c1ccc(-c2cnn3c2CN(c2ccnc4[nH]ccc24)CC3)cc1 Homo sapiens CHEMBL3379628 single protein format
CHEMBL3355073 IC50 = 1.0 nM 414.54 C[C@@H]1Cn2ncc(C3CCN(S(C)(=O)=O)CC3)c2CN1c1ccnc2[nH]ccc12 Homo sapiens CHEMBL3379628 single protein format
CHEMBL5394792 IC50 = 1.0 nM 444.54 C[C@@H]1COCCN1c1nc(-n2c(N)nc3ccccc32)nc2c(S(C)(=O)=O)csc12 Homo sapiens CHEMBL5322975 single protein format
CHEMBL5417125 IC50 = 1.2 nM 462.53 C[C@@H]1COCCN1c1nc(-n2c(N)nc3cc(F)ccc32)nc2c(S(C)(=O)=O)csc12 Homo sapiens CHEMBL5322975 single protein format
CHEMBL5434673 IC50 = 1.5 nM 458.57 CNc1nc2ccccc2n1-c1nc(N2CCOC[C@H]2C)c2scc(S(C)(=O)=O)c2n1 Homo sapiens CHEMBL5322975 single protein format
CHEMBL4281240 IC50 = 2.0 nM 413.5 C[C@@H]1COCCN1c1cc(C2(S(C)(=O)=O)CC2)nc(-c2cncc3[nH]ccc23)n1 Homo sapiens CHEMBL4269677 single protein format
CHEMBL4291436 IC50 = 2.0 nM 442.55 CNc1nc2ccccc2n1-c1nc(N2CCOC[C@H]2C)cc(C2(S(C)(=O)=O)CC2)n1 Homo sapiens CHEMBL4269677 single protein format
CHEMBL4286105 IC50 = 2.0 nM 446.51 C[C@@H]1COCCN1c1cc(C2(S(C)(=O)=O)CC2)nc(-n2c(N)nc3cc(F)ccc32)n1 Homo sapiens CHEMBL4269677 single protein format
CHEMBL4635442 IC50 = 2.0 nM 395.51 C[C@@H]1COCCN1c1cc(C(C)(O)C(C)(C)C)c2ccnc(-c3ccn[nH]3)c2n1 Homo sapiens CHEMBL4612706 cell-based format
CHEMBL3352844 IC50 = 2.0 nM 415.52 C[C@@H]1Cn2ncc(C3CCN(S(C)(=O)=O)CC3)c2CN1c1ccnc2[nH]cnc12 Homo sapiens CHEMBL3379628 single protein format