Q13510 | ASAH1_HUMAN | Acid ceramidase (ASAH1)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF02275 | CBAH - Linear amide C-N hydrolases, choloylglycine hydrolase family | 143~384 | |
| PF15508 | NAAA-beta - beta subunit of N-acylethanolamine-hydrolyzing acid amidase | 45~107 |
3D structures mapped by conservation among orthologs
[ Domain: "Penicillin acylase, catalytic domain" // CBAH ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL3741996 |  |
IC50 | = | 0.8 | nM | 386.45 | O=C(NCCCCc1ccccc1)n1c(=O)oc2cccc(-c3ccccc3)c21 | Homo sapiens | CHEMBL3743922 | cell-based format |
| CHEMBL4093029 |  |
IC50 | = | 0.9 | nM | 308.38 | Nc1nc2ccccc2n1C(=O)NCCCCc1ccccc1 | Homo sapiens | CHEMBL4013053 | cell-based format |
| CHEMBL4103207 |  |
IC50 | = | 1.0 | nM | 307.4 | Cc1nc2ccccc2n1C(=O)NCCCCc1ccccc1 | Homo sapiens | CHEMBL4013053 | cell-based format |
| CHEMBL4084295 |  |
IC50 | = | 1.3 | nM | 295.35 | O=C(NCCCCc1ccccc1)n1nnc2ncccc21 | Homo sapiens | CHEMBL4013053 | cell-based format |
| CHEMBL4092051 |  |
IC50 | = | 2.1 | nM | 294.36 | O=C(NCCCCc1ccccc1)n1nnc2ccccc21 | Homo sapiens | CHEMBL4013053 | cell-based format |
| CHEMBL4062592 |  |
IC50 | = | 2.2 | nM | 247.3 | CCCCCCNC(=O)n1nnc2ncccc21 | Homo sapiens | CHEMBL4013053 | cell-based format |
| CHEMBL4075447 |  |
IC50 | = | 2.4 | nM | 322.36 | O=C(NCCCCc1ccccc1)N1C(=O)c2ccccc2C1=O | Homo sapiens | CHEMBL4013053 | cell-based format |
| CHEMBL4065362 |  |
IC50 | = | 2.4 | nM | 260.34 | CCCCCCNC(=O)n1c(N)nc2ccccc21 | Homo sapiens | CHEMBL4013053 | cell-based format |
| CHEMBL4100744 |  |
IC50 | = | 2.5 | nM | 293.37 | O=C(NCCCCc1ccccc1)n1cnc2ccccc21 | Homo sapiens | CHEMBL4013053 | cell-based format |
| CHEMBL4580541 |  |
IC50 | = | 3.0 | nM | 311.34 | O=C(NCCCCc1ccccc1)n1c(=O)oc2cnccc21 | Homo sapiens | CHEMBL4344763 | cell-based format |
| CHEMBL3741606 |  |
IC50 | = | 3.0 | nM | 355.35 | O=C(NCCCCc1ccccc1)n1c(=O)oc2cc([N+](=O)[O-])ccc21 | Homo sapiens | CHEMBL3743922 | cell-based format |
| CHEMBL3741624 |  |
IC50 | = | 3.0 | nM | 355.35 | O=C(NCCCCc1ccccc1)n1c(=O)oc2ccc([N+](=O)[O-])cc21 | Homo sapiens | CHEMBL3743922 | cell-based format |
| CHEMBL4071239 |  |
IC50 | = | 4.1 | nM | 246.31 | CCCCCCNC(=O)n1nnc2ccccc21 | Homo sapiens | CHEMBL4013053 | cell-based format |
| CHEMBL4075028 |  |
IC50 | = | 4.7 | nM | 293.37 | O=C(NCCCCc1ccccc1)n1ncc2ccccc21 | Homo sapiens | CHEMBL4013053 | cell-based format |
| CHEMBL4742096 |  |
IC50 | = | 5.0 | nM | 370.84 | O=C(NCCCCc1ccccc1)n1c(-c2ccc(Cl)cc2)coc1=O | Homo sapiens | CHEMBL4712399 | single protein format |
| CHEMBL4592427 |  |
IC50 | = | 6.0 | nM | 311.34 | O=C(NCCCCc1ccccc1)n1c(=O)oc2ccncc21 | Homo sapiens | CHEMBL4344763 | cell-based format |
| CHEMBL66205 |  |
IC50 | = | 6.6 | nM | 245.33 | CCCCCCNC(=O)n1cnc2ccccc21 | Homo sapiens | CHEMBL4013053 | cell-based format |
| CHEMBL4096883 |  |
IC50 | = | 7.0 | nM | 280.33 | Cc1ccc(CNC(=O)n2c(N)nc3ccccc32)cc1 | Homo sapiens | CHEMBL4013053 | cell-based format |
| CHEMBL4089655 |  |
IC50 | = | 7.0 | nM | 274.32 | CCCCCCNC(=O)N1C(=O)c2ccccc2C1=O | Homo sapiens | CHEMBL4013053 | cell-based format |
| CHEMBL2333055 |  |
IC50 | = | 7.7 | nM | 357.38 | CCCCCCNC(=O)n1cc(F)c(=O)n(C(=O)OCC(C)C)c1=O | Homo sapiens | CHEMBL4712392 | single protein format |