Q13507 | TRPC3_HUMAN | Short transient receptor potential channel 3 (TRPC3)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00520 | Ion_trans - Ion transport protein | 485~754 | |
| PF08344 | TRP_2 - Transient receptor ion channel II | 267~329 | |
| PF12796 | Ank_2 - Ankyrin repeats (3 copies) | 118~197 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL2418809 |  |
IC50 | = | 32.0 | nM | 411.89 | CC1CCCN(C(=O)c2nc(Nc3cc4c(cc3F)OCO4)sc2Cl)C1C | Homo sapiens | CHEMBL2422305 | cell-based format |
| CHEMBL2418807 |  |
IC50 | = | 80.0 | nM | 359.45 | CC1CCCN(C(=O)c2csc(Nc3ccc4c(c3)OCO4)n2)C1C | Homo sapiens | CHEMBL2422305 | cell-based format |
| CHEMBL2418811 |  |
IC50 | = | 100.0 | nM | 381.9 | Cc1sc(Nc2ccc(Cl)cc2F)nc1C(=O)N1CCC[C@H](C)[C@@H]1C | Homo sapiens | CHEMBL2422305 | cell-based format |
| CHEMBL2418808 |  |
IC50 | = | 160.0 | nM | 391.47 | Cc1sc(Nc2cc3c(cc2F)OCO3)nc1C(=O)N1CCCC(C)C1C | Homo sapiens | CHEMBL2422305 | cell-based format |
| CHEMBL2418806 |  |
IC50 | = | 250.0 | nM | 329.47 | Cc1ccc(Nc2nc(C(=O)N3CCCC(C)C3C)cs2)cc1 | Homo sapiens | CHEMBL2422305 | cell-based format |
| CHEMBL2418810 |  |
IC50 | = | 250.0 | nM | 381.9 | Cc1sc(Nc2ccc(Cl)cc2F)nc1C(=O)N1CCCC(C)C1C | Homo sapiens | CHEMBL2422305 | cell-based format |
| CHEMBL4129809 |  |
IC50 | = | 282.0 | nM | 367.88 | N#Cc1ccc(O[C@@H]2c3ccccc3C[C@H]2N2CCC[C@@H](N)C2)c(Cl)c1 | Homo sapiens | CHEMBL4377108 | cell-based format |
| CHEMBL2418815 |  |
IC50 | = | 316.0 | nM | 407.5 | Cc1sc(Nc2ccc3c(c2)OCO3)nc1C(=O)N1CCc2ccccc2C1C | Homo sapiens | CHEMBL2422305 | cell-based format |
| CHEMBL2418814 |  |
IC50 | = | 316.0 | nM | 393.47 | CC1c2ccccc2CCN1C(=O)c1csc(Nc2ccc3c(c2)OCO3)n1 | Homo sapiens | CHEMBL2422305 | cell-based format |
| CHEMBL4761535 |  |
IC50 | = | 370.0 | nM | 445.23 | CCNC(=O)c1cnn(-c2ccc(-n3ccc(Cl)c(Cl)c3=O)cc2)c1C(F)(F)F | Homo sapiens | CHEMBL4714754 | cell-based format |
| CHEMBL2418823 |  |
IC50 | = | 400.0 | nM | 345.42 | CC1CCN(C(=O)c2csc(Nc3ccc4c(c3)OCO4)n2)CC1 | Homo sapiens | CHEMBL2422305 | cell-based format |
| CHEMBL2418813 |  |
IC50 | = | 500.0 | nM | 379.44 | O=C(c1csc(Nc2ccc3c(c2)OCO3)n1)N1CCc2ccccc2C1 | Homo sapiens | CHEMBL2422305 | cell-based format |
| CHEMBL2418818 |  |
IC50 | = | 630.0 | nM | 315.44 | Cc1ccc(Nc2nc(C(=O)N3CCC(C)CC3)cs2)cc1 | Homo sapiens | CHEMBL2422305 | cell-based format |
| CHEMBL4177187 |  |
IC50 | = | 700.0 | nM | 456.64 | CCOC(=O)c1cnn(-c2ccc(NC(=O)C(Cl)=C(Cl)Cl)cc2)c1C(F)(F)F | Homo sapiens | CHEMBL4377098 | single protein format |
| CHEMBL4460029 |  |
IC50 | = | 720.0 | nM | 449.38 | Cc1ccc(S(=O)(=O)Nc2ccc(-n3nc(C(F)(F)F)cc3C(F)(F)F)cc2)cc1 | Homo sapiens | CHEMBL4377100 | cell-based format |
| CHEMBL2418824 |  |
IC50 | = | 800.0 | nM | 315.44 | Cc1ccc(Nc2nc(C(=O)N3CCCCC3C)cs2)cc1 | Homo sapiens | CHEMBL2422305 | cell-based format |
| CHEMBL2418820 |  |
IC50 | = | 800.0 | nM | 331.44 | COc1ccc(Nc2nc(C(=O)N3CCC(C)CC3)cs2)cc1 | Homo sapiens | CHEMBL2422305 | cell-based format |
| CHEMBL2418819 |  |
IC50 | = | 800.0 | nM | 335.86 | CC1CCN(C(=O)c2csc(Nc3ccc(Cl)cc3)n2)CC1 | Homo sapiens | CHEMBL2422305 | cell-based format |
| CHEMBL2418812 |  |
IC50 | = | 1000.0 | nM | 381.9 | Cc1sc(Nc2ccc(Cl)cc2F)nc1C(=O)N1CCC[C@@H](C)[C@H]1C | Homo sapiens | CHEMBL2422305 | cell-based format |