Q13393 | PLD1_HUMAN | Phospholipase D1 (PLD1)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00169 | PH - PH domain | 222~327 | |
| PF00614 | PLDc - Phospholipase D Active site motif | 459~486 | |
| PF00787 | PX - PX domain | 108~207 | |
| PF13091 | PLDc_2 - PLD-like domain | 769~937 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL4453586 |  |
IC50 | = | 1.0 | nM | 448.54 | C[C@@H](CN1CCC2(CC1)C(=O)NC[C@H]2c1ccc(F)cc1)NC(=O)c1cc2ccccc2[nH]1 | Homo sapiens | CHEMBL4329649 | cell-based format |
| CHEMBL2304616 |  |
IC50 | = | 2.0 | nM | 438.96 | O=C(NCCN1CCC(n2c(=O)[nH]c3cc(Cl)ccc32)CC1)C1C[C@@H]1c1ccccc1 | Homo sapiens | CHEMBL957604 | cell-based format |
| CHEMBL493521 |  |
IC50 | = | 2.0 | nM | 446.53 | C[C@@H](CN1CCC(n2c(=O)[nH]c3ccc(F)cc32)CC1)NC(=O)c1ccc2ccccc2c1 | Homo sapiens | CHEMBL957604 | cell-based format |
| CHEMBL492561 |  |
IC50 | = | 3.0 | nM | 477.79 | O=C(NCCN1CCC(n2c(=O)[nH]c3cc(Br)ccc32)CC1)c1ccc(Cl)cc1 | Homo sapiens | CHEMBL957604 | cell-based format |
| CHEMBL492558 |  |
IC50 | = | 3.0 | nM | 448.9 | C[C@@H](CN1CCC(n2c(=O)[nH]c3cc(Cl)ccc32)CC1)NC(=O)c1ccc(F)c(F)c1 | Homo sapiens | CHEMBL957604 | cell-based format |
| CHEMBL492559 |  |
IC50 | = | 3.5 | nM | 493.35 | C[C@@H](CN1CCC(n2c(=O)[nH]c3cc(Br)ccc32)CC1)NC(=O)c1ccc(F)c(F)c1 | Homo sapiens | CHEMBL957604 | cell-based format |
| CHEMBL524182 |  |
IC50 | = | 3.7 | nM | 497.44 | C[C@@H](CN1CCC(n2c(=O)[nH]c3cc(Br)ccc32)CC1)NC(=O)[C@@H]1C[C@H]1c1ccccc1 | Homo sapiens | CHEMBL957604 | cell-based format |
| CHEMBL3947795 |  |
IC50 | = | 3.7 | nM | 497.44 | C[C@@H](CN1CCC(n2c(=O)[nH]c3cc(Br)ccc32)CC1)NC(=O)[C@@H]1C[C@@H]1c1ccccc1 | Homo sapiens | CHEMBL3889074 | cell-based format |
| CHEMBL493010 |  |
IC50 | = | 4.0 | nM | 432.5 | O=C(NCCN1CCC(n2c(=O)[nH]c3cc(F)ccc32)CC1)c1ccc2ccccc2c1 | Homo sapiens | CHEMBL957604 | cell-based format |
| CHEMBL521990 |  |
IC50 | = | 4.0 | nM | 461.34 | O=C(NCCN1CCC(n2c(=O)[nH]c3cc(Br)ccc32)CC1)c1ccc(F)cc1 | Homo sapiens | CHEMBL957604 | cell-based format |
| CHEMBL492972 |  |
IC50 | = | 4.0 | nM | 418.42 | O=C(NCCN1CCC(n2c(=O)[nH]c3ccc(F)cc32)CC1)c1ccc(F)c(F)c1 | Homo sapiens | CHEMBL957604 | cell-based format |
| CHEMBL523011 |  |
IC50 | = | 4.0 | nM | 491.82 | C[C@@H](CN1CCC(n2c(=O)[nH]c3cc(Br)ccc32)CC1)NC(=O)c1ccc(Cl)cc1 | Homo sapiens | CHEMBL957604 | cell-based format |
| CHEMBL492704 |  |
IC50 | = | 5.5 | nM | 507.43 | C[C@@H](CN1CCC(n2c(=O)[nH]c3cc(Br)ccc32)CC1)NC(=O)c1ccc2ccccc2c1 | Homo sapiens | CHEMBL957604 | cell-based format |
| CHEMBL3357311 |  |
IC50 | = | 6.0 | nM | 431.54 | CC(CNC(=O)c1cc2ccccc2[nH]1)N1CCC2(CC1)C(=O)NCN2c1ccccc1 | Homo sapiens | CHEMBL3379086 | cell-based format |
| CHEMBL4446255 |  |
IC50 | = | 6.0 | nM | 489.39 | C[C@@H](CN1CCC2(CC1)C(=O)NCN2c1cccc(F)c1)NC(=O)c1ccc(Br)cc1 | Homo sapiens | CHEMBL4329645 | single protein format |
| CHEMBL494145 |  |
IC50 | = | 6.4 | nM | 447.37 | C[C@@H](CN1CCC(n2c(=O)[nH]c3cc(Cl)ccc32)CC1)NC(=O)c1ccc(Cl)cc1 | Homo sapiens | CHEMBL957604 | cell-based format |
| CHEMBL492971 |  |
IC50 | = | 7.0 | nM | 416.88 | O=C(NCCN1CCC(n2c(=O)[nH]c3ccc(F)cc32)CC1)c1ccc(Cl)cc1 | Homo sapiens | CHEMBL957604 | cell-based format |
| CHEMBL522488 |  |
IC50 | = | 7.4 | nM | 430.91 | C[C@@H](CN1CCC(n2c(=O)[nH]c3cc(F)ccc32)CC1)NC(=O)c1ccc(Cl)cc1 | Homo sapiens | CHEMBL957604 | cell-based format |
| CHEMBL246032 |  |
IC50 | = | 8.0 | nM | 415.5 | O=C(NCCN1CCC(n2c(=O)[nH]c3ccccc32)CC1)c1cnc2ccccc2c1 | Homo sapiens | CHEMBL957604 | cell-based format |
| CHEMBL521677 |  |
IC50 | = | 8.0 | nM | 452.99 | C[C@@H](CN1CCC(n2c(=O)[nH]c3cc(Cl)ccc32)CC1)NC(=O)[C@@H]1C[C@H]1c1ccccc1 | Homo sapiens | CHEMBL957604 | cell-based format |