Q13370 | PDE3B_HUMAN | cGMP-inhibited 3',5'-cyclic phosphodiesterase B (PDE3B)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00233 | PDEase_I - 3'5'-cyclic nucleotide phosphodiesterase | 736~1002 |
3D structures mapped by conservation among orthologs
[ Domain: "HD-domain/PDEase-like" // PDEase_I ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL338860 |  |
IC50 | = | 0.049 | nM | 508.58 | C[C@@H]1CC(=O)NN=C1c1ccc(NC2=C(Cc3ccccc3-c3cccc([N+](=O)[O-])c3)C(=O)CCC2)cc1 | Homo sapiens | CHEMBL761482 | assay format |
| CHEMBL339210 |  |
IC50 | = | 0.068 | nM | 469.61 | C[C@@H]1CC(=O)NN=C1c1ccc(NC2=C(Cc3ccccc3-c3ccsc3)C(=O)CCC2)cc1 | Homo sapiens | CHEMBL761482 | assay format |
| CHEMBL131355 |  |
IC50 | = | 0.11 | nM | 513.38 | CC1CC(=O)NN=C1c1ccc(NC2=C(Cc3cccc(I)c3)C(=O)CCC2)cc1 | Homo sapiens | CHEMBL761482 | assay format |
| CHEMBL129668 |  |
IC50 | = | 0.13 | nM | 474.36 | CC1(C)C(=O)NN=C1c1ccc(NC2=C(Cc3c(Cl)cccc3Cl)C(=O)CCC2)cc1F | Homo sapiens | CHEMBL761482 | assay format |
| CHEMBL131111 |  |
IC50 | = | 0.13 | nM | 417.51 | COc1ccccc1CC1=C(Nc2ccc(C3=NNC(=O)CC3C)cc2)CCCC1=O | Homo sapiens | CHEMBL761482 | assay format |
| CHEMBL128456 |  |
IC50 | = | 0.19 | nM | 387.48 | C[C@@H]1CC(=O)NN=C1c1ccc(NC2=C(Cc3ccccc3)C(=O)CCC2)cc1 | Homo sapiens | CHEMBL761482 | assay format |
| CHEMBL338179 |  |
IC50 | = | 0.24 | nM | 405.47 | CC1CC(=O)NN=C1c1ccc(NC2=C(Cc3ccccc3)C(=O)CCC2)cc1F | Homo sapiens | CHEMBL761482 | assay format |
| CHEMBL128391 |  |
IC50 | = | 0.26 | nM | 405.47 | CC1CC(=O)NN=C1c1ccc(/N=C2\CCCC(O)=C2Cc2ccccc2)c(F)c1 | Homo sapiens | CHEMBL761482 | assay format |
| CHEMBL128621 |  |
IC50 | = | 0.3 | nM | 466.38 | CC1CC(=O)NN=C1c1ccc(NC2=C(Cc3cccc(Br)c3)C(=O)CCC2)cc1 | Homo sapiens | CHEMBL761482 | assay format |
| CHEMBL129283 |  |
IC50 | = | 0.33 | nM | 448.47 | CC1(C)C(=O)NN=C1c1ccc(/N=C2\CCCC(O)=C2Cc2cccc(C#N)c2)c(F)c1F | Homo sapiens | CHEMBL761482 | assay format |
| CHEMBL338381 |  |
IC50 | = | 0.35 | nM | 455.48 | CC1CC(=O)NN=C1c1ccc(NC2=C(Cc3ccccc3C(F)(F)F)C(=O)CCC2)cc1 | Homo sapiens | CHEMBL761482 | assay format |
| CHEMBL130081 |  |
IC50 | = | 0.53 | nM | 439.92 | CC1(C)C(=O)NN=C1c1ccc(NC2=C(Cc3ccccc3Cl)C(=O)CCC2)cc1F | Homo sapiens | CHEMBL761482 | assay format |
| CHEMBL131939 |  |
IC50 | = | 0.61 | nM | 401.51 | Cc1cc(C2=NNC(=O)CC2C)ccc1/N=C1\CCCC(O)=C1Cc1ccccc1 | Homo sapiens | CHEMBL761482 | assay format |
| CHEMBL130026 |  |
IC50 | = | 0.62 | nM | 423.46 | CC1CC(=O)NN=C1c1cc(F)c(NC2=C(Cc3ccccc3)C(=O)CCC2)cc1F | Homo sapiens | CHEMBL761482 | assay format |
| CHEMBL129255 |  |
IC50 | = | 0.7 | nM | 417.51 | COc1ccc(CC2=C(Nc3ccc(C4=NNC(=O)CC4C)cc3)CCCC2=O)cc1 | Homo sapiens | CHEMBL761482 | assay format |
| CHEMBL341231 |  |
IC50 | = | 0.7 | nM | 405.47 | CC1CC(=O)NN=C1c1ccc(NC2=C(Cc3cccc(F)c3)C(=O)CCC2)cc1 | Homo sapiens | CHEMBL761482 | assay format |
| CHEMBL341354 |  |
IC50 | = | 0.94 | nM | 432.48 | CC1CC(=O)NN=C1c1ccc(NC2=C(Cc3cccc([N+](=O)[O-])c3)C(=O)CCC2)cc1 | Homo sapiens | CHEMBL761482 | assay format |
| CHEMBL129692 |  |
IC50 | = | 1.0 | nM | 337.38 | CC1CC(=O)NN=C1c1ccc(NC(=O)OCc2ccccc2)cc1 | Homo sapiens | CHEMBL761482 | assay format |
| CHEMBL131672 |  |
IC50 | = | 1.1 | nM | 423.46 | CC1(C)C(=O)NN=C1c1ccc(NC2=C(Cc3ccccc3F)C(=O)CCC2)cc1F | Homo sapiens | CHEMBL761482 | assay format |
| CHEMBL128485 |  |
IC50 | = | 2.5 | nM | 405.47 | CC1(C)C(=O)NN=C1c1ccc(NC2=C(Cc3ccccc3)C(=O)CCC2)cc1F | Homo sapiens | CHEMBL761482 | assay format |