Q13258 | PD2R_HUMAN | Prostaglandin D2 receptor (PTGDR)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00001 | 7tm_1 - 7 transmembrane receptor (rhodopsin family) | 59~323 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL116836 |  |
IC50 | = | 0.27 | nM | 443.58 | CC1(C)[C@H]2C[C@H](C/C=C\CCCC(=O)O)[C@@H](NC(=O)c3csc4ccc(F)cc34)[C@@H]1C2 | Homo sapiens | CHEMBL767849 | assay format |
| CHEMBL116837 |  |
IC50 | = | 0.4 | nM | 441.59 | CC1(C)[C@H]2C[C@H](C/C=C\CCCC(=O)O)[C@@H](NC(=O)c3csc4ccc(O)cc34)[C@@H]1C2 | Homo sapiens | CHEMBL767849 | assay format |
| CHEMBL79943 |  |
IC50 | = | 0.42 | nM | 443.58 | CC1(C)[C@H]2C[C@H](C/C=C/CCCC(=O)O)[C@@H](NC(=O)c3csc4ccc(F)cc34)[C@@H]1C2 | Homo sapiens | CHEMBL768775 | assay format |
| CHEMBL119810 |  |
IC50 | = | 1.3 | nM | 441.59 | CC1(C)[C@H]2C[C@H](C/C=C\CCCC(=O)O)[C@@H](NC(=O)c3csc4cc(O)ccc34)[C@@H]1C2 | Homo sapiens | CHEMBL767849 | assay format |
| CHEMBL426559 |  |
IC50 | = | 1.4 | nM | 435.9 | CS(=O)(=O)c1cc(F)cc2c3c(n(Cc4ccc(Cl)cc4)c12)[C@@H](CC(=O)O)CC3 | Homo sapiens | CHEMBL907965 | single protein format |
| CHEMBL311790 |  |
IC50 | = | 1.9 | nM | 441.59 | CC1(C)[C@H]2C[C@H](C/C=C/CCCC(=O)O)[C@@H](NC(=O)c3csc4ccc(O)cc34)[C@@H]1C2 | Homo sapiens | CHEMBL768775 | assay format |
| CHEMBL4226404 |  |
IC50 | = | 2.0 | nM | 487.5 | CS(=O)(=O)c1cc(F)cc2c1c(Sc1ccc(C(F)(F)F)cc1)c1n2CC[C@@H]1CC(=O)O | Homo sapiens | CHEMBL4222141 | single protein format |
| CHEMBL84452 |  |
IC50 | = | 2.2 | nM | 441.59 | CC1(C)[C@H]2C[C@H](C/C=C/CCCC(=O)O)[C@@H](NC(=O)c3csc4cc(O)ccc34)[C@@H]1C2 | Homo sapiens | CHEMBL768775 | assay format |
| CHEMBL1950879 |  |
IC50 | = | 4.0 | nM | 590.49 | CCCc1cc(-c2ccc(Oc3ccc(CC(=O)O)cc3OC)c(NS(=O)(=O)c3ccc(Cl)cc3Cl)c2)n[nH]1 | Homo sapiens | CHEMBL1953543 | cell-based format |
| CHEMBL1950870 |  |
IC50 | = | 5.0 | nM | 591.47 | CCCCNC(=O)c1ccc(Oc2ccc3c(CC(=O)O)coc3c2)c(NS(=O)(=O)c2ccc(Cl)cc2Cl)c1 | Homo sapiens | CHEMBL1953543 | cell-based format |
| CHEMBL1951562 |  |
IC50 | = | 6.0 | nM | 565.48 | CCCCNC(=O)c1ccc(Oc2ccc(CC(=O)O)cc2C)c(NS(=O)(=O)c2ccc(Cl)cc2Cl)c1 | Homo sapiens | CHEMBL1955370 | cell-based format |
| CHEMBL1950871 |  |
IC50 | = | 6.0 | nM | 579.5 | CCCCNC(=O)c1ccc(Cc2ccc(CC(=O)O)cc2OC)c(NS(=O)(=O)c2ccc(Cl)cc2Cl)c1 | Homo sapiens | CHEMBL1953543 | cell-based format |
| CHEMBL1951566 |  |
IC50 | = | 7.0 | nM | 587.43 | CCCCNC(=O)c1ccc(Oc2cc(F)c(CC(=O)O)cc2F)c(NS(=O)(=O)c2ccc(Cl)cc2Cl)c1 | Homo sapiens | CHEMBL1955370 | cell-based format |
| CHEMBL1951563 |  |
IC50 | = | 8.0 | nM | 585.89 | CCCCNC(=O)c1ccc(Oc2ccc(CC(=O)O)cc2Cl)c(NS(=O)(=O)c2ccc(Cl)cc2Cl)c1 | Homo sapiens | CHEMBL1955370 | cell-based format |
| CHEMBL82489 |  |
IC50 | = | 8.6 | nM | 477.63 | O=C(O)CCC/C=C\C[C@@H]1[C@H]2CC[C@H](C2)[C@H]1NS(=O)(=O)c1ccc(C#Cc2ccccc2)cc1 | Homo sapiens | CHEMBL767849 | assay format |
| CHEMBL1951568 |  |
IC50 | = | 9.0 | nM | 583.88 | O=C(O)Cc1ccc(Oc2ccc(C(=O)NC3CCC3)cc2NS(=O)(=O)c2ccc(Cl)cc2Cl)c(Cl)c1 | Homo sapiens | CHEMBL1955370 | cell-based format |
| CHEMBL3287081 |  |
IC50 | = | 9.0 | nM | 535.41 | COc1cc(CC(=O)O)ccc1Oc1ccc2c(ccn2C)c1NS(=O)(=O)c1ccc(Cl)cc1Cl | Homo sapiens | CHEMBL3295026 | cell-based format |
| CHEMBL569521 |  |
IC50 | = | 9.0 | nM | 595.5 | CCCCCNC(=O)c1ccc(Oc2ccc(CC(=O)O)cc2OC)c(NS(=O)(=O)c2ccc(Cl)cc2Cl)c1 | Homo sapiens | CHEMBL1047088 | cell-based format |
| CHEMBL1950877 |  |
IC50 | = | 10.0 | nM | 591.47 | CCCc1nc(-c2ccc(Oc3ccc(CC(=O)O)cc3OC)c(NS(=O)(=O)c3ccc(Cl)cc3Cl)c2)n[nH]1 | Homo sapiens | CHEMBL1953543 | cell-based format |
| CHEMBL1950878 |  |
IC50 | = | 10.0 | nM | 590.49 | CCCc1nc(-c2ccc(Oc3ccc(CC(=O)O)cc3OC)c(NS(=O)(=O)c3ccc(Cl)cc3Cl)c2)c[nH]1 | Homo sapiens | CHEMBL1953543 | cell-based format |