Q13255 | GRM1_HUMAN | Metabotropic glutamate receptor 1 (GRM1)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00003 | 7tm_3 - 7 transmembrane sweet-taste receptor of 3 GCPR | 586~834 | |
| PF01094 | ANF_receptor - Receptor family ligand binding region | 79~486 | |
| PF07562 | NCD3G - Nine Cysteines Domain of family 3 GPCR | 520~571 | |
| PF10606 | GluR_Homer-bdg - Homer-binding domain of metabotropic glutamate receptor | 1144~1194 |
3D structures mapped by conservation among orthologs
[ Domain: "Family A G protein-coupled receptor-like" // 7tm_3 ]
[ Domain: "Periplasmic binding protein-like I" // ANF_receptor_2nd_1 ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL174588 |  |
IC50 | = | 0.55 | nM | 325.41 | CO[C@H]1CC[C@@H](C(=O)c2ccc3nc4c(cc3c2)CCCO4)CC1 | Homo sapiens | CHEMBL874546 | single protein format |
| CHEMBL178690 |  |
IC50 | = | 0.56 | nM | 309.41 | CO[C@H]1CC[C@@H](C(=O)c2ccc3nc4c(cc3c2)CCC4)CC1 | Homo sapiens | CHEMBL874546 | single protein format |
| CHEMBL2112967 |  |
IC50 | = | 1.0 | nM | 312.41 | CCc1cc2cc(C(=O)[C@H]3CC[C@@H](OC)CC3)ccc2nc1N | Homo sapiens | CHEMBL874546 | single protein format |
| CHEMBL175463 |  |
IC50 | = | 2.0 | nM | 327.45 | CO[C@H]1CC[C@@H](C(=O)c2ccc3nc4c(cc3c2)CCS4)CC1 | Homo sapiens | CHEMBL874546 | single protein format |
| CHEMBL176279 |  |
IC50 | = | 3.0 | nM | 311.43 | CCCc1ccc2cc(C(=O)[C@H]3CC[C@@H](OC)CC3)ccc2n1 | Homo sapiens | CHEMBL874546 | single protein format |
| CHEMBL1645352 |  |
IC50 | = | 3.6 | nM | 305.32 | Cc1c(-c2ccc3ncccc3c2)nnn1-c1cccnc1F | Homo sapiens | CHEMBL1647364 | single protein format |
| CHEMBL178592 |  |
IC50 | = | 4.0 | nM | 331.84 | CCc1cc2cc(C(=O)C3CCC(OC)CC3)ccc2nc1Cl | Homo sapiens | CHEMBL874546 | single protein format |
| CHEMBL360728 |  |
IC50 | = | 6.0 | nM | 325.45 | CCCc1cc2cc(C(=O)[C@H]3CC[C@@H](OC)CC3)ccc2nc1C | Homo sapiens | CHEMBL874546 | single protein format |
| CHEMBL177519 |  |
IC50 | = | 7.0 | nM | 333.39 | CCc1cc2cc(C(=O)C3COc4ccccc4O3)ccc2nc1C | Homo sapiens | CHEMBL874546 | single protein format |
| CHEMBL175377 |  |
IC50 | = | 8.0 | nM | 325.45 | CCc1cc2cc(C(=O)C3CCC(OC)CC3)ccc2nc1CC | Homo sapiens | CHEMBL874546 | single protein format |
| CHEMBL2112964 |  |
IC50 | = | 9.0 | nM | 315.39 | CCc1cc2cc(C(=O)[C@H]3CC[C@@H](OC)CC3)ccc2nc1F | Homo sapiens | CHEMBL874546 | single protein format |
| CHEMBL369459 |  |
IC50 | = | 14.0 | nM | 303.36 | O=C(Cc1ccccc1)c1ccc2nc3c(cc2c1)CCCO3 | Homo sapiens | CHEMBL874546 | single protein format |
| CHEMBL2112048 |  |
IC50 | = | 16.0 | nM | 321.46 | C[C@H]1CC[C@@H](C(=O)c2ccc3nc4c(cc3c2)CCCCC4)CC1 | Homo sapiens | CHEMBL874546 | single protein format |
| CHEMBL178741 |  |
IC50 | = | 18.0 | nM | 337.46 | CO[C@H]1CC[C@@H](C(=O)c2ccc3nc4c(cc3c2)CCCCC4)CC1 | Homo sapiens | CHEMBL874546 | single protein format |
| CHEMBL174216 |  |
IC50 | = | 29.0 | nM | 338.45 | CO[C@H]1CC[C@@H](C(=O)c2ccc3nc4c(cc3c2)CCCN4C)CC1 | Homo sapiens | CHEMBL874546 | single protein format |
| CHEMBL177586 |  |
IC50 | = | 51.0 | nM | 289.38 | CCc1cc2cc(C(=O)Cc3ccccc3)ccc2nc1C | Homo sapiens | CHEMBL874546 | single protein format |
| CHEMBL177043 |  |
IC50 | = | 62.0 | nM | 423.29 | CCc1cc2cc(C(=O)C3CCC(OC)CC3)ccc2nc1I | Homo sapiens | CHEMBL874546 | single protein format |
| CHEMBL178742 |  |
IC50 | = | 74.0 | nM | 309.39 | O=C(Cc1ccsc1)c1ccc2nc3c(cc2c1)CCCO3 | Homo sapiens | CHEMBL874546 | single protein format |
| CHEMBL177585 |  |
IC50 | = | 80.0 | nM | 297.4 | CCc1cc2cc(C(=O)C3CCC(O)CC3)ccc2nc1C | Homo sapiens | CHEMBL874546 | single protein format |
| CHEMBL175699 |  |
IC50 | = | 85.0 | nM | 325.45 | CCc1cc2cc(C(=O)C[C@H]3CC[C@@H](OC)CC3)ccc2nc1C | Homo sapiens | CHEMBL874546 | single protein format |