Q13237 | KGP2_HUMAN | cGMP-dependent protein kinase 2 (PRKG2)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00027 | cNMP_binding - Cyclic nucleotide-binding domain | 187~268 | |
| PF00027 | cNMP_binding - Cyclic nucleotide-binding domain | 305~390 | |
| PF00069 | Pkinase - Protein kinase domain | 455~711 |
3D structures mapped by conservation among orthologs
[ Domain: "Double-stranded beta-helix" // cNMP_binding_1 ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL388978 |  |
IC50 | = | 5.77 | nM | 466.54 | CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 | Homo sapiens | CHEMBL4328576 | single protein format |
| CHEMBL1082821 |  |
IC50 | = | 24.0 | nM | 402.28 | O=C(Nc1cc2cc[nH]c(=O)c2cc1Cl)[C@@H]1CNC[C@H]1c1ccc(Cl)cc1 | Homo sapiens | CHEMBL1120084 | single protein format |
| CHEMBL5433617 |  |
IC50 | = | 34.0 | nM | 299.36 | Cn1cncc1C1=CN(c2ncnc3[nH]cnc23)CCS1 | Homo sapiens | CHEMBL5373869 | single protein format |
| CHEMBL5426285 |  |
IC50 | = | 118.0 | nM | 358.47 | COC[C@@H](CC(C)C)NC1=N/C(=C\c2ccc3ncsc3c2)C(=O)N1 | Homo sapiens | CHEMBL5378520 | single protein format |
| CHEMBL5082933 |  |
IC50 | = | 380.0 | nM | 402.41 | CC(C)C[C@](C)(N)COc1ccc(-c2ccnc(C(F)F)c2)cc1C(F)(F)F | Homo sapiens | CHEMBL5049739 | single protein format |
| CHEMBL5088205 |  |
IC50 | = | 420.0 | nM | 384.42 | CC(C)C[C@](C)(N)COc1ccc(-c2ccnc(C(F)F)c2)cc1C(F)F | Homo sapiens | CHEMBL5049739 | single protein format |
| CHEMBL4538174 |  |
IC50 | = | 950.0 | nM | 311.35 | C[C@@H](NC(=O)Nc1cc2[nH]ncc2c(CO)n1)c1ccccc1 | Homo sapiens | CHEMBL4882614 | single protein format |