Q13233 | M3K1_HUMAN | Mitogen-activated protein kinase kinase kinase 1 (MAP3K1)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00069 | Pkinase - Protein kinase domain | 1245~1508 | |
| PF04434 | SWIM - SWIM zinc finger | 338~364 | |
| PF21040 | CEP104-like_TOG - Centrosomal protein CEP104-like, TOG domain | 556~812 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL2216826 |  |
IC50 | = | 31.0 | nM | 389.45 | CCNc1cc(O)c2c(c1)/C=C/C[C@@H](O)[C@H](O)C(=O)/C=C\[C@H](C)[C@H](C)OC2=O | Homo sapiens | CHEMBL2217253 | single protein format |
| CHEMBL1097700 |  |
IC50 | = | 46.0 | nM | 375.42 | CNc1cc(O)c2c(c1)/C=C/C[C@H](O)[C@H](O)C(=O)/C=C\[C@@H](C)[C@H](C)OC2=O | Homo sapiens | CHEMBL3880860 | single protein format |
| CHEMBL3577124 |  |
IC50 | = | 98.0 | nM | 424.52 | CNc1ncc2cc(-c3cc(NC(=O)NCCC(C)(C)C)c(F)cc3C)c(C)nc2n1 | Homo sapiens | CHEMBL3578503 | cell-based format |
| CHEMBL388978 |  |
IC50 | = | 485.0 | nM | 466.54 | CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 | Homo sapiens | CHEMBL4328491 | single protein format |
| CHEMBL5092087 |  |
IC50 | = | 840.0 | nM | 421.51 | Cc1c(Nc2nc(N)c3c(C#N)c(N4CCC[C@H]4C)n(C)c3n2)cnn1[C@H]1CCOC1 | Homo sapiens | CHEMBL5040133 | assay format |