Q13231 | CHIT1_HUMAN | Chitotriosidase-1 (CHIT1)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00704 | Glyco_hydro_18 - Glycosyl hydrolases family 18 | 23~363 | |
| PF01607 | CBM_14 - Chitin binding Peritrophin-A domain | 420~465 |
3D structures mapped by conservation among orthologs
[ Domain: "Chitinase insertion domain" // GH18_chitolectin_chitotriosidase ]
[ Domain: "TIM barrels" // Glyco_hydro_18 ]
[ Domain: "Invertebrate chitin-binding proteins" // CBM_14 ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL4776610 |  |
IC50 | = | 14.0 | nM | 404.95 | CC[C@H]1CN(C2CCN(c3nc(N)n[nH]3)CC2)[C@@H](Cc2ccc(Cl)cc2)CO1 | Homo sapiens | CHEMBL4704014 | cell-based format |
| CHEMBL4756869 |  |
IC50 | = | 16.0 | nM | 433.0 | CC(C)C[C@H]1CN(C2CCN(c3nc(N)n[nH]3)CC2)[C@@H](Cc2ccc(Cl)cc2)CO1 | Homo sapiens | CHEMBL4704014 | cell-based format |
| CHEMBL4794014 |  |
IC50 | = | 18.0 | nM | 418.97 | CC(C)[C@H]1CN(C2CCN(c3nc(N)n[nH]3)CC2)[C@@H](Cc2ccc(Cl)cc2)CO1 | Homo sapiens | CHEMBL4704014 | cell-based format |
| CHEMBL4464754 |  |
IC50 | = | 21.0 | nM | 418.97 | Nc1n[nH]c(N2CCC(N(CCc3ccc(Cl)cc3)CC3CCCCO3)CC2)n1 | Homo sapiens | CHEMBL4312826 | cell-based format |
| CHEMBL4789376 |  |
IC50 | = | 22.0 | nM | 406.92 | Nc1n[nH]c(N2CCC(N3C[C@H](CO)OC[C@@H]3Cc3ccc(Cl)cc3)CC2)n1 | Homo sapiens | CHEMBL4704014 | cell-based format |
| CHEMBL4755139 |  |
IC50 | = | 22.0 | nM | 420.95 | COC[C@H]1CN(C2CCN(c3nc(N)n[nH]3)CC2)[C@@H](Cc2ccc(Cl)cc2)CO1 | Homo sapiens | CHEMBL4704014 | cell-based format |
| CHEMBL4764430 |  |
IC50 | = | 23.0 | nM | 434.97 | CC(C)(O)[C@H]1CN(C2CCN(c3nc(N)n[nH]3)CC2)[C@@H](Cc2ccc(Cl)cc2)CO1 | Homo sapiens | CHEMBL4704014 | cell-based format |
| CHEMBL4788866 |  |
IC50 | = | 23.0 | nM | 390.92 | C[C@H]1CN(C2CCN(c3nc(N)n[nH]3)CC2)[C@@H](Cc2ccc(Cl)cc2)CO1 | Homo sapiens | CHEMBL4704014 | cell-based format |
| CHEMBL4541831 |  |
IC50 | = | 27.0 | nM | 404.95 | Nc1n[nH]c(N2CCC(N(CCc3ccc(Cl)cc3)CC3CCCO3)CC2)n1 | Homo sapiens | CHEMBL4312826 | cell-based format |
| CHEMBL4749391 |  |
IC50 | = | 32.0 | nM | 433.94 | CNC(=O)[C@H]1CN(C2CCN(c3nc(N)n[nH]3)CC2)[C@@H](Cc2ccc(Cl)cc2)CO1 | Homo sapiens | CHEMBL4704014 | cell-based format |
| CHEMBL4084573 |  |
IC50 | = | 36.0 | nM | 461.01 | Nc1n[nH]c(N2CCC(N(CCc3ccc(Cl)cc3)Cc3cccc4ccccc34)CC2)n1 | Homo sapiens | CHEMBL4022941 | cell-based format |
| CHEMBL4580568 |  |
IC50 | = | 41.0 | nM | 374.92 | Nc1n[nH]c(N2CCC(N3CCCC[C@@H]3Cc3ccc(Cl)cc3)CC2)n1 | Homo sapiens | CHEMBL4312826 | cell-based format |
| CHEMBL4520755 |  |
IC50 | = | 44.0 | nM | 392.94 | CO[C@@H](C)CN(CCc1ccc(Cl)cc1)C1CCN(c2nc(N)n[nH]2)CC1 | Homo sapiens | CHEMBL4312826 | cell-based format |
| CHEMBL4470253 |  |
IC50 | = | 44.0 | nM | 390.92 | CO[C@@H]1C[C@H](Cc2ccc(Cl)cc2)N(C2CCN(c3nc(N)n[nH]3)CC2)C1 | Homo sapiens | CHEMBL4312826 | cell-based format |
| CHEMBL4537828 |  |
IC50 | = | 47.0 | nM | 390.92 | CO[C@H]1C[C@H](Cc2ccc(Cl)cc2)N(C2CCN(c3nc(N)n[nH]3)CC2)C1 | Homo sapiens | CHEMBL4312826 | cell-based format |
| CHEMBL4461925 |  |
IC50 | = | 48.0 | nM | 376.89 | Nc1n[nH]c(N2CCC(N3CCOC[C@@H]3Cc3ccc(Cl)cc3)CC2)n1 | Homo sapiens | CHEMBL4312826 | cell-based format |
| CHEMBL4637417 |  |
IC50 | = | 49.0 | nM | 426.95 | Nc1nc(N2CCC(N(CCc3ccc(Cl)cc3)Cc3ccccc3O)CC2)n[nH]1 | Homo sapiens | CHEMBL4619015 | cell-based format |
| CHEMBL4588384 |  |
IC50 | = | 59.0 | nM | 360.89 | Nc1n[nH]c(N2CCC(N3CCC[C@@H]3Cc3ccc(Cl)cc3)CC2)n1 | Homo sapiens | CHEMBL4312826 | cell-based format |
| CHEMBL4634943 |  |
IC50 | = | 79.0 | nM | 426.95 | Nc1nc(N2CCC(N(CCc3ccc(Cl)cc3)Cc3cccc(O)c3)CC2)n[nH]1 | Homo sapiens | CHEMBL4619015 | cell-based format |
| CHEMBL4442663 |  |
IC50 | = | 82.0 | nM | 376.89 | Nc1n[nH]c(N2CCC(N3C[C@@H](O)C[C@@H]3Cc3ccc(Cl)cc3)CC2)n1 | Homo sapiens | CHEMBL4312826 | cell-based format |