Q13224 | NMDE2_HUMAN | Glutamate receptor ionotropic, NMDA 2B (GRIN2B)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00060 | Lig_chan - Ligand-gated ion channel | 556~829 | |
| PF01094 | ANF_receptor - Receptor family ligand binding region | 108~316 | |
| PF10565 | NMDAR2_C - N-methyl D-aspartate receptor 2B3 C-terminus | 840~1484 | |
| PF10613 | Lig_chan-Glu_bd - Ligated ion channel L-glutamate- and glycine-binding site | 455~540 |
3D structures mapped by conservation among orthologs
[ Domain: "Periplasmic binding protein-like I" // ANF_receptor_3rd ]
[ Domain: "Periplasmic binding protein-like I" // ANF_receptor_2nd ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL159560 |  |
IC50 | = | 4.1 | nM | 324.3 | COc1ccccc1C/N=C(\N)c1ccc(OC(F)(F)F)cc1 | Homo sapiens | CHEMBL749390 | single protein format |
| CHEMBL5416465 |  |
IC50 | = | 4.2 | nM | 352.73 | Nc1nccn1Cc1cn(-c2ccc(Cl)c(C(=O)C(F)F)c2)nn1 | Homo sapiens | CHEMBL5319821 | single protein format |
| CHEMBL159744 |  |
IC50 | = | 4.2 | nM | 322.33 | Cc1cc(C)cc(C/N=C(\N)c2ccc(OC(F)(F)F)cc2)c1 | Homo sapiens | CHEMBL749390 | single protein format |
| CHEMBL4111330 |  |
IC50 | = | 4.2 | nM | 368.45 | O=C1[C@H](N2CCC(c3ccc(O)cc3)CC2)CCN1Cc1ccc(F)cc1 | Homo sapiens | CHEMBL4149864 | cell-based format |
| CHEMBL162080 |  |
IC50 | = | 8.7 | nM | 306.33 | Cc1cc(C)cc(C/N=C(\N)c2ccc(C(F)(F)F)cc2)c1 | Homo sapiens | CHEMBL749390 | single protein format |
| CHEMBL305195 |  |
IC50 | = | 9.0 | nM | 339.48 | C[C@@H](CN1CCC(Cc2ccccc2)CC1)[C@@H](O)c1ccc(O)cc1 | Homo sapiens | CHEMBL4309004 | cell-based format |
| CHEMBL349727 |  |
IC50 | = | 9.7 | nM | 324.3 | COc1cccc(C/N=C(\N)c2ccc(OC(F)(F)F)cc2)c1 | Homo sapiens | CHEMBL749390 | single protein format |
| CHEMBL17350 |  |
IC50 | = | 11.0 | nM | 327.42 | C[C@@H]([C@@H](O)c1ccc(O)cc1)N1CCC(O)(c2ccccc2)CC1 | Homo sapiens | CHEMBL5255361 | single protein format |
| CHEMBL4287203 |  |
IC50 | = | 12.0 | nM | 325.45 | COc1ccc2c(c1)CC[C@H](NCCCc1ccccc1)C[C@@H]2O | Homo sapiens | CHEMBL4261996 | cell-based format |
| CHEMBL3545350 |  |
IC50 | = | 12.0 | nM | 318.3 | Cc1nccn1Cc1cc(-c2ccc(F)c(C(F)F)c2)cnn1 | Homo sapiens | CHEMBL4309004 | cell-based format |
| CHEMBL305187 |  |
IC50 | = | 20.0 | nM | 325.45 | CC(C(O)c1ccc(O)cc1)N1CCC(Cc2ccccc2)CC1 | Homo sapiens | CHEMBL3108300 | single protein format |
| CHEMBL3892956 |  |
IC50 | = | 24.0 | nM | 382.48 | Cc1ccc(CN2CC[C@@H](N3CC[C@@H](c4ccc(O)cc4)[C@H](F)C3)C2=O)cc1 | Homo sapiens | CHEMBL4149864 | cell-based format |
| CHEMBL161180 |  |
IC50 | = | 24.0 | nM | 363.17 | N=C(NCc1cc(Cl)cc(Cl)c1)c1ccc(OC(F)(F)F)cc1 | Homo sapiens | CHEMBL749390 | single protein format |
| CHEMBL159558 |  |
IC50 | = | 32.0 | nM | 312.72 | N=C(NCc1cccc(Cl)c1)c1ccc(C(F)(F)F)cc1 | Homo sapiens | CHEMBL749390 | single protein format |
| CHEMBL161421 |  |
IC50 | = | 46.0 | nM | 294.28 | N=C(NCc1ccccc1)c1ccc(OC(F)(F)F)cc1 | Homo sapiens | CHEMBL749390 | single protein format |
| CHEMBL159279 |  |
IC50 | = | 47.0 | nM | 362.27 | N=C(NCc1ccccc1C(F)(F)F)c1ccc(OC(F)(F)F)cc1 | Homo sapiens | CHEMBL749390 | single protein format |
| CHEMBL421976 |  |
IC50 | = | 48.0 | nM | 312.72 | N=C(NCc1ccccc1Cl)c1ccc(C(F)(F)F)cc1 | Homo sapiens | CHEMBL749390 | single protein format |
| CHEMBL44301 |  |
IC50 | = | 50.0 | nM | 320.44 | Oc1ccc2c3c([nH]c2c1)CN(CCCCc1ccccc1)CC3 | Homo sapiens | CHEMBL5235564 | single protein format |
| CHEMBL161876 |  |
IC50 | = | 57.0 | nM | 363.17 | N=C(NCc1ccccc1OC(F)(F)F)c1ccc(Cl)c(Cl)c1 | Homo sapiens | CHEMBL749390 | single protein format |
| CHEMBL5435354 |  |
IC50 | = | 62.0 | nM | 349.48 | O[C@H](CCN1CCC(Cc2ccccc2)CC1)c1ccc2[nH]ncc2c1 | Homo sapiens | CHEMBL5365007 | cell-based format |