Q13188 | STK3_HUMAN | Serine/threonine-protein kinase 3 (STK3)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00069 | Pkinase - Protein kinase domain | 28~278 | |
| PF11629 | Mst1_SARAH - C terminal SARAH domain of Mst1 | 437~484 |
3D structures mapped by conservation among orthologs
[ Domain: "NAP-like" // Mst1_SARAH ]
[ Domain: "Protein kinase" // Pkinase_Tyr ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL388978 |  |
IC50 | = | 0.41 | nM | 466.54 | CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 | Homo sapiens | CHEMBL973450 | single protein format |
| CHEMBL4116008 |  |
IC50 | = | 4.0 | nM | 445.55 | CCS(=O)(=O)N1CCN(c2ccc(Nc3ncc(C(N)=O)c(NC4CC4)n3)cc2)CC1 | Homo sapiens | CHEMBL5347026 | single protein format |
| CHEMBL2010872 |  |
IC50 | = | 21.0 | nM | 477.57 | CC(C)Cn1c2ccc(Nc3ncccn3)cc2c2c3c(c4c(c21)CCc1nn(C)cc1-4)C(=O)NC3 | Homo sapiens | CHEMBL2016115 | single protein format |
| CHEMBL3393348 |  |
IC50 | = | 22.0 | nM | 305.34 | N#Cc1cccc(-c2c[nH]c3ncnc(N4CCOCC4)c23)c1 | Homo sapiens | CHEMBL3395732 | single protein format |
| CHEMBL5089935 |  |
IC50 | = | 36.0 | nM | 369.86 | CC(=O)NC1CCN(c2ncnc3[nH]cc(-c4cccc(Cl)c4)c23)CC1 | Homo sapiens | CHEMBL5043420 | assay format |
| CHEMBL4554938 |  |
IC50 | = | 38.1 | nM | 416.49 | CN1C(=O)c2sccc2N(C)c2nc(Nc3ccc(S(N)(=O)=O)cc3)ncc21 | Homo sapiens | CHEMBL5212989 | single protein format |
| CHEMBL4281823 |  |
IC50 | = | 50.0 | nM | 481.48 | CCn1cc(-c2ccc3c(c2)CCN3C(=O)Cc2cccc(OC(F)(F)F)c2)c2c(N)ncnc21 | Homo sapiens | CHEMBL4261441 | single protein format |
| CHEMBL5092052 |  |
IC50 | = | 58.0 | nM | 330.82 | CC(CO)CN(C)c1ncnc2[nH]cc(-c3cccc(Cl)c3)c12 | Homo sapiens | CHEMBL5043420 | assay format |
| CHEMBL605003 |  |
IC50 | = | 110.0 | nM | 371.46 | CN(C)S(=O)(=O)c1ccc2c(c1)/C(=C/c1cc3c([nH]1)CCCC3)C(=O)N2 | Homo sapiens | CHEMBL1061941 | single protein format |
| CHEMBL5076098 |  |
IC50 | = | 117.0 | nM | 302.76 | CN(CCO)c1ncnc2[nH]cc(-c3cccc(Cl)c3)c12 | Homo sapiens | CHEMBL5043420 | assay format |
| CHEMBL5093114 |  |
IC50 | = | 119.0 | nM | 313.79 | Clc1cccc(-c2c[nH]c3nccc(N4CCOCC4)c23)c1 | Homo sapiens | CHEMBL5043420 | assay format |
| CHEMBL3942417 |  |
IC50 | = | 121.0 | nM | 294.36 | Cc1cccc(-c2c[nH]c3ncnc(N4CCOCC4)c23)c1 | Homo sapiens | CHEMBL5043420 | assay format |
| CHEMBL5089132 |  |
IC50 | = | 127.0 | nM | 328.8 | OC1CCN(c2ncnc3[nH]cc(-c4cccc(Cl)c4)c23)CC1 | Homo sapiens | CHEMBL5043420 | assay format |
| CHEMBL3393355 |  |
IC50 | = | 127.0 | nM | 314.78 | Clc1cccc(-c2c[nH]c3ncnc(N4CCOCC4)c23)c1 | Homo sapiens | CHEMBL5043420 | assay format |
| CHEMBL5082941 |  |
IC50 | = | 167.0 | nM | 312.8 | Clc1cccc(-c2c[nH]c3ncnc(N4CCCCC4)c23)c1 | Homo sapiens | CHEMBL5043420 | assay format |
| CHEMBL5093841 |  |
IC50 | = | 173.0 | nM | 302.77 | OCCCNc1ncnc2[nH]cc(-c3cccc(Cl)c3)c12 | Homo sapiens | CHEMBL5043420 | assay format |
| CHEMBL3393444 |  |
IC50 | = | 179.0 | nM | 319.37 | C[C@H]1CN(c2ncnc3[nH]cc(-c4cccc(C#N)c4)c23)CCO1 | Homo sapiens | CHEMBL3395732 | single protein format |
| CHEMBL5087568 |  |
IC50 | = | 189.0 | nM | 342.83 | CC1(O)CCN(c2ncnc3[nH]cc(-c4cccc(Cl)c4)c23)CC1 | Homo sapiens | CHEMBL5043420 | assay format |
| CHEMBL3923604 |  |
IC50 | = | 191.0 | nM | 298.32 | Fc1cccc(-c2c[nH]c3ncnc(N4CCOCC4)c23)c1 | Homo sapiens | CHEMBL5043420 | assay format |
| CHEMBL3393446 |  |
IC50 | = | 196.0 | nM | 344.38 | N#CCC1CN(c2ncnc3[nH]cc(-c4cccc(C#N)c4)c23)CCO1 | Homo sapiens | CHEMBL3395732 | single protein format |