Q13177 | PAK2_HUMAN | Serine/threonine-protein kinase PAK 2 (PAK2)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00069 | Pkinase - Protein kinase domain | 249~500 | |
| PF00786 | PBD - P21-Rho-binding domain | 73~130 |
3D structures mapped by conservation among orthologs
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL388978 |  |
IC50 | = | 1.0 | nM | 466.54 | CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 | Homo sapiens | CHEMBL1021076 | single protein format |
| CHEMBL3770443 |  |
IC50 | = | 11.0 | nM | 492.97 | CNc1ncc2cc(-c3ccc(-c4cccc(C)n4)cc3Cl)c(=O)n(C[C@H]3OC[C@H](N)CO3)c2n1 | Homo sapiens | CHEMBL3772532 | single protein format |
| CHEMBL3609327 |  |
IC50 | = | 12.8 | nM | 558.11 | CCn1c(=O)c(-c2ccc(-c3cncs3)cc2Cl)cc2cnc(Nc3ccc(N4CCN(C)CC4)cc3)nc21 | Homo sapiens | CHEMBL3611427 | single protein format |
| CHEMBL3609326 |  |
IC50 | = | 39.5 | nM | 513.4 | CCn1c(=O)c(-c2ccc(Cl)cc2Cl)cc2cnc(Nc3ccc(N4CCNCC4)c(F)c3)nc21 | Homo sapiens | CHEMBL3611546 | single protein format |
| CHEMBL5090394 |  |
IC50 | = | 41.0 | nM | 496.93 | CNc1ncc2cc(-c3ccc(-c4ncccc4F)cc3Cl)c(=O)n(C[C@H]3OC[C@H](N)CO3)c2n1 | Homo sapiens | CHEMBL5151384 | single protein format |
| CHEMBL2386715 |  |
IC50 | = | 64.1 | nM | 422.47 | COCCN(Cc1cc(F)cc2[nH]ncc12)c1nccc(Nc2cc(C3CC3)[nH]n2)n1 | Homo sapiens | CHEMBL2388904 | cell-based format |
| CHEMBL2386717 |  |
IC50 | = | 70.8 | nM | 422.47 | CC(CO)N(Cc1cc(F)cc2[nH]ncc12)c1nccc(Nc2cc(C3CC3)[nH]n2)n1 | Homo sapiens | CHEMBL2388904 | cell-based format |
| CHEMBL2386716 |  |
IC50 | = | 133.0 | nM | 373.46 | C[C@H](Nc1nccc(Nc2cc(C3CCC3)[nH]n2)n1)c1ccc2[nH]ccc2c1 | Homo sapiens | CHEMBL2388904 | cell-based format |
| CHEMBL3128043 |  |
IC50 | = | 190.0 | nM | 490.64 | Cc1nc(Nc2n[nH]c3c2CN(C(=O)N[C@H](CN(C)C)c2ccccc2)C3(C)C)c2sccc2n1 | Homo sapiens | CHEMBL3611421 | single protein format |
| CHEMBL2386718 |  |
IC50 | = | 244.0 | nM | 396.41 | C[C@H](Nc1nccc(Nc2cc(C3CC3(F)F)[nH]n2)n1)c1ccc2[nH]cnc2c1 | Homo sapiens | CHEMBL2388904 | cell-based format |
| CHEMBL5274607 |  |
IC50 | = | 824.0 | nM | 479.93 | CC(C)NC(=O)N1CC[C@@H](NC2=Nc3cc(F)ccc3N(CC(F)F)c3ccc(Cl)cc32)C1 | Homo sapiens | CHEMBL5238738 | single protein format |
| CHEMBL3128042 |  |
IC50 | = | 970.0 | nM | 406.49 | COCCNc1nc2ccc(C#CC3(O)CCCCC3)cc2n1-c1ccnc(N)n1 | Homo sapiens | CHEMBL3129190 | single protein format |
| CHEMBL3818265 |  |
Ki | = | 2.0 | nM | 508.99 | CNc1ncc2cc(-c3ccc(-n4cccc(C)c4=O)cc3Cl)c(=O)n(CCC3(F)CN(C)C3)c2n1 | Homo sapiens | CHEMBL3820957 | single protein format |
| CHEMBL3818479 |  |
Ki | = | 4.6 | nM | 570.0 | Cc1nccn(-c2ccc(-c3cc4cnc(NC5COC5)nc4n(CC4CCNCC4(F)F)c3=O)c(Cl)c2)c1=O | Homo sapiens | CHEMBL3820957 | single protein format |
| CHEMBL3819118 |  |
Ki | = | 9.5 | nM | 506.99 | CCc1cccn(-c2ccc(-c3cc4cnc(NC)nc4n(C[C@H]4CNCCO4)c3=O)c(Cl)c2)c1=O | Homo sapiens | CHEMBL3820957 | single protein format |
| CHEMBL3770443 | |
Ki | = | 11.0 | nM | 492.97 | CNc1ncc2cc(-c3ccc(-c4cccc(C)n4)cc3Cl)c(=O)n(C[C@H]3OC[C@H](N)CO3)c2n1 | Homo sapiens | CHEMBL3820957 | single protein format |
| CHEMBL3817984 |  |
Ki | = | 21.0 | nM | 463.93 | CCn1c(=O)c(-c2ccc(-n3cccc(C)c3=O)cc2Cl)cc2cnc(NC3COC3)nc21 | Homo sapiens | CHEMBL3820957 | single protein format |
| CHEMBL3819447 |  |
Ki | = | 39.0 | nM | 452.9 | CNc1ncc2cc(-c3ccc(-n4cncc(C)c4=O)cc3Cl)c(=O)n(CCOC)c2n1 | Homo sapiens | CHEMBL3820957 | single protein format |
| CHEMBL3770186 |  |
Ki | = | 48.0 | nM | 518.07 | CCn1c(=O)c(-c2ccc(-c3cncc(C)n3)cc2Cl)cc2cnc(NCCC3CCN(C)CC3)nc21 | Homo sapiens | CHEMBL3820957 | single protein format |
| CHEMBL3819371 |  |
Ki | = | 940.0 | nM | 460.97 | Cc1cncc(-c2ccc(-c3cc4cncnc4n(C[C@H]4CC[C@H](N)CC4)c3=O)c(Cl)c2)n1 | Homo sapiens | CHEMBL3820957 | single protein format |