Q13164 | MK07_HUMAN | Mitogen-activated protein kinase 7 (MAPK7)
Pfam Domain Table
| Accession | Domain | Range | Color |
|---|---|---|---|
| PF00069 | Pkinase - Protein kinase domain | 55~347 |
3D structures mapped by conservation among orthologs
[ Domain: "Protein kinase" // Pkinase_Tyr ]
[ Alpha Fold Model ] (go)
Known binders annotated in ChEMBL
Only the first 20 rows are shown.
| molecule_chembl_id | structure | assay_type | relation | value | unit | mol_wt | smiles | organism | assay_chembl_id | bao_label |
|---|---|---|---|---|---|---|---|---|---|---|
| CHEMBL5175191 |  |
IC50 | = | 5.0 | nM | 476.34 | O=C(Nc1ccc(CN2CCNCC2)nc1)c1cc(C(=O)c2c(Cl)ccc(Cl)c2F)c[nH]1 | Homo sapiens | CHEMBL5166085 | single protein format |
| CHEMBL5188920 |  |
IC50 | = | 5.0 | nM | 490.37 | CN1CCN(Cc2ccc(NC(=O)c3cc(C(=O)c4c(Cl)ccc(Cl)c4F)c[nH]3)cn2)CC1 | Homo sapiens | CHEMBL5166085 | single protein format |
| CHEMBL5186248 |  |
IC50 | = | 6.0 | nM | 489.38 | CN1CCC(Cc2ccc(NC(=O)c3cc(C(=O)c4c(Cl)ccc(Cl)c4F)c[nH]3)cn2)CC1 | Homo sapiens | CHEMBL5166085 | single protein format |
| CHEMBL5198962 |  |
IC50 | = | 7.0 | nM | 464.33 | O=C(Nc1cnn(CC2CCNCC2)c1)c1cc(C(=O)c2c(Cl)ccc(Cl)c2F)c[nH]1 | Homo sapiens | CHEMBL5166085 | single protein format |
| CHEMBL5197199 |  |
IC50 | = | 7.0 | nM | 491.35 | CN1CCN(Cc2ncc(NC(=O)c3cc(C(=O)c4c(Cl)ccc(Cl)c4F)c[nH]3)cn2)CC1 | Homo sapiens | CHEMBL5166085 | single protein format |
| CHEMBL5172952 |  |
IC50 | = | 8.0 | nM | 477.33 | O=C(Nc1cnc(CN2CCNCC2)nc1)c1cc(C(=O)c2c(Cl)ccc(Cl)c2F)c[nH]1 | Homo sapiens | CHEMBL5166085 | single protein format |
| CHEMBL4757477 |  |
IC50 | = | 11.0 | nM | 554.7 | CCOc1cc(C(=O)N2CCC(N3CCCC3)CC2)ccc1Nc1cc2c(cn1)N(C)C(=O)c1ccccc1N2C | Homo sapiens | CHEMBL4724823 | single protein format |
| CHEMBL5175007 |  |
IC50 | = | 13.0 | nM | 463.3 | O=C(Nc1cnc(N2CCNCC2)nc1)c1cc(C(=O)c2c(Cl)ccc(Cl)c2F)c[nH]1 | Homo sapiens | CHEMBL5166085 | single protein format |
| CHEMBL5202924 |  |
IC50 | = | 13.0 | nM | 462.31 | O=C(Nc1ccc(N2CCNCC2)nc1)c1cc(C(=O)c2c(Cl)ccc(Cl)c2F)c[nH]1 | Homo sapiens | CHEMBL5166085 | single protein format |
| CHEMBL5173346 |  |
IC50 | = | 14.0 | nM | 491.35 | CN1CCC(Nc2ncc(NC(=O)c3cc(C(=O)c4c(Cl)ccc(Cl)c4F)c[nH]3)cn2)CC1 | Homo sapiens | CHEMBL5166085 | single protein format |
| CHEMBL5175760 |  |
IC50 | = | 14.0 | nM | 491.35 | CN1CCC(Oc2ccc(NC(=O)c3cc(C(=O)c4c(Cl)ccc(Cl)c4F)c[nH]3)cn2)CC1 | Homo sapiens | CHEMBL5166085 | single protein format |
| CHEMBL5208879 |  |
IC50 | = | 16.0 | nM | 478.36 | CN1CCC(Cn2cc(NC(=O)c3cc(C(=O)c4c(Cl)ccc(Cl)c4F)c[nH]3)cn2)CC1 | Homo sapiens | CHEMBL5166085 | single protein format |
| CHEMBL4438379 |  |
IC50 | = | 17.0 | nM | 487.48 | O=C(c1ccc(OC(F)(F)F)cc1)N1CCC(c2ncnc3cc(N4CCOCC4)cnc23)CC1 | Homo sapiens | CHEMBL4332025 | assay format |
| CHEMBL5180089 |  |
IC50 | = | 19.0 | nM | 450.3 | O=C(Nc1cnn(C2CCNCC2)c1)c1cc(C(=O)c2c(Cl)ccc(Cl)c2F)c[nH]1 | Homo sapiens | CHEMBL5166085 | single protein format |
| CHEMBL5208123 |  |
IC50 | = | 22.0 | nM | 464.33 | CN1CCC(n2cc(NC(=O)c3cc(C(=O)c4c(Cl)ccc(Cl)c4F)c[nH]3)cn2)CC1 | Homo sapiens | CHEMBL5166085 | single protein format |
| CHEMBL5193573 |  |
IC50 | = | 25.0 | nM | 504.39 | CN1CCC(N(C)c2ccc(NC(=O)c3cc(C(=O)c4c(Cl)ccc(Cl)c4F)c[nH]3)cn2)CC1 | Homo sapiens | CHEMBL5166085 | single protein format |
| CHEMBL4445670 |  |
IC50 | = | 35.0 | nM | 515.54 | CN1CCN(c2cnc3c(C4CCN(C(=O)c5ccc(OC(F)(F)F)cc5N)CC4)ncnc3c2)CC1 | Homo sapiens | CHEMBL4332025 | assay format |
| CHEMBL5179461 |  |
IC50 | = | 37.0 | nM | 477.33 | CN1CCN(c2ncc(NC(=O)c3cc(C(=O)c4c(Cl)ccc(Cl)c4F)c[nH]3)cn2)CC1 | Homo sapiens | CHEMBL5166085 | single protein format |
| CHEMBL1944698 |  |
IC50 | = | 43.0 | nM | 372.47 | CN1C/C=C/CCOc2cccc(c2)-c2ccnc(n2)Nc2cccc(c2)C1 | Homo sapiens | CHEMBL5340252 | single protein format |
| CHEMBL4469661 |  |
IC50 | = | 51.0 | nM | 446.43 | COc1ccc2c(C3CCN(C(=O)c4ccc(OC(F)(F)F)cc4N)CC3)ncnc2c1 | Homo sapiens | CHEMBL4332025 | assay format |